AXSM vs ALGN

Comparison between Axsome Therapeutics Inc (AXSM, Company) and Align Technology Inc (ALGN, Company).

Both AXSM and ALGN are from the Healthcare sector.

5-Year PerformanceAXSM has outperformed ALGN, delivering a return of +26.9% compared to -21.9%

AXSM vs ALGN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AXSM(COMPANY)	ALGN(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	86.65%	92.30%
Sharpe Ratio	2.14	0.15
5Y Beta	0.65	1.34
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-63.99	28.56
Forward P/E	333.33	15.70
PEG Ratio	0.00	3.44
5Y EPS CAGR	6.89%	0.63%
Debt to Equity	344.13%	0.00%
Free Cash Flow Yield	-0.58%	4.77%
P/S Ratio	17.49	2.99
P/B Ratio	224.29	2.91

Market Cap

AXSM

$12B

Winner

ALGN

$12B

Max Drawdown

Winner

AXSM

86.65%

ALGN

92.30%

Sharpe Ratio

Winner

AXSM

2.14

ALGN

0.15

5Y Beta

Winner

AXSM

0.65

ALGN

1.34

Industry

AXSM

Biotechnology

ALGN

Medical Instruments & Supplies

P/E Ratio

Winner

AXSM

-63.99

ALGN

28.56

Forward P/E

AXSM

333.33

Winner

ALGN

15.70

PEG Ratio

Winner

AXSM

0.00

ALGN

3.44

5Y EPS CAGR

Winner

AXSM

6.89%

ALGN

0.63%

Debt to Equity

AXSM

344.13%

Winner

ALGN

0.00%

Free Cash Flow Yield

AXSM

-0.58%

Winner

ALGN

4.77%

P/S Ratio

AXSM

17.49

Winner

ALGN

2.99

P/B Ratio

AXSM

224.29

Winner

ALGN

2.91

AXSM vs ALGN - Historical Returns

Returns include dividend reinvestment.

Period	AXSM	ALGN
1 month	+3.19%	+9.10%
3 months	+47.12%	+0.62%
6 months	+58.94%	+12.67%
1 year	+135.61%	-4.96%
5 years(CAGR)	+26.87%	-21.92%
10 years(CAGR)	+41.26%	+8.74%
Max(CAGR)	+36.77%	+9.73%

AXSM

+3.19%

Winner

ALGN

+9.10%

Winner

AXSM

+47.12%

ALGN

+0.62%

Winner

AXSM

+58.94%

ALGN

+12.67%

Winner

AXSM

+135.61%

ALGN

-4.96%

5Y(CAGR)

Winner

AXSM

+26.87%

ALGN

-21.92%

10Y(CAGR)

Winner

AXSM

+41.26%

ALGN

+8.74%

Max(CAGR)

Winner

AXSM

+36.77%

ALGN

+9.73%

AXSM vs ALGN - Annual Returns (2001 - 2026)

Returns include dividend reinvestment.

Year	AXSM	ALGN
2026	+35.25%	+14.36%
2025	+109.16%	-25.10%
2024	+9.80%	-22.46%
2023	+8.55%	+29.07%
2022	+103.89%	-67.46%
2021	-53.61%	+24.83%
2020	-19.58%	+88.37%
2019	+3756.72%	+38.06%
2018	-48.49%	-6.76%
2017	-13.18%	+129.16%
2016	-44.63%	+49.57%
2015	+6.06%	+17.17%
2014	N/A	-1.84%
2013	N/A	+101.20%
2012	N/A	+15.87%
2011	N/A	+19.40%
2010	N/A	+5.62%
2009	N/A	+100.45%
2008	N/A	-46.87%
2007	N/A	+24.94%
2006	N/A	+122.45%
2005	N/A	-38.73%
2004	N/A	-35.59%
2003	N/A	+502.77%
2002	N/A	-35.79%
2001	N/A	-73.34%

AXSM vs ALGN Drawdown Comparison

The maximum drawdown for AXSM was -86.65%, occurring on Dec 27, 2018. Recovery took 809 trading sessions.

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The current AXSM drawdown is -5.29%. The current ALGN drawdown is -75.55%.

Rank	AXSM	ALGN
#1	-86.65% Jan 5, 2016 - Mar 25, 2019	-92.30% Jan 30, 2001 - Nov 3, 2003
#2	-81.26% Dec 26, 2019 - Jan 30, 2025	-82.89% Sep 8, 2021 - Sep 25, 2025
#3	-42.70% Sep 16, 2019 - Nov 19, 2019	-82.58% Oct 24, 2007 - Apr 24, 2012
#4	-30.56% Feb 21, 2025 - Nov 6, 2025	-75.18% Apr 19, 2004 - Apr 26, 2007
#5	-18.50% Jan 21, 2026 - Apr 30, 2026	-64.95% Sep 25, 2018 - Oct 22, 2020
#6	-17.63% Mar 25, 2019 - Apr 25, 2019	-35.18% Sep 13, 2012 - Jul 10, 2013
#7	-17.48% Jul 26, 2019 - Sep 16, 2019	-30.62% Jan 17, 2014 - Jun 16, 2015
#8	-17.26% May 28, 2019 - Jun 20, 2019	-22.28% Jan 26, 2018 - May 11, 2018
#9	-11.38% Jun 20, 2019 - Jun 27, 2019	-20.05% Feb 5, 2021 - Apr 27, 2021
#10	-10.33% Nov 24, 2015 - Dec 29, 2015	-18.56% Jul 25, 2007 - Oct 4, 2007
#11	-9.37% Jul 2, 2019 - Jul 26, 2019	-18.32% Jul 20, 2015 - Oct 23, 2015
#12	-8.83% Dec 4, 2019 - Dec 10, 2019	-17.71% Jan 26, 2004 - Apr 12, 2004
#13	-8.26% Dec 31, 2025 - Jan 20, 2026	-17.21% Nov 28, 2017 - Jan 17, 2018
#14	-7.23% Feb 5, 2025 - Feb 10, 2025	-14.67% Dec 1, 2003 - Jan 7, 2004
#15	-6.99% Jun 12, 2026 - Jun 25, 2026	-14.09% Oct 26, 2015 - Mar 2, 2016