AXSM vs AGNC

Comparison between Axsome Therapeutics Inc (AXSM, Company) and AGNC Investment Corp (AGNC, Company).

AXSM is from the Healthcare sector, while AGNC is from the Real Estate sector.

5-Year PerformanceAXSM has outperformed AGNC, delivering a return of +29.9% compared to +5.2%

AXSM vs AGNC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AXSM(COMPANY)	AGNC(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	86.65%	81.08%
Sharpe Ratio	2.18	1.44
5Y Beta	0.65	0.66
Industry	Biotechnology	Reit - Mortgage
P/E Ratio	-64.72	8.00
Forward P/E	333.33	6.75
PEG Ratio	0.00	0.05
Dividend Yield	N/A	13.40%
5Y Dividends CAGR	N/A	1.61%
5Y EPS CAGR	6.89%	-25.22%
Debt to Equity	344.13%	0.00%
Free Cash Flow Yield	-0.57%	6.85%
P/S Ratio	17.49	7.87
P/B Ratio	226.87	1.21

Market Cap

AXSM

$12B

Winner

AGNC

$12B

Max Drawdown

AXSM

86.65%

Winner

AGNC

81.08%

Sharpe Ratio

Winner

AXSM

2.18

AGNC

1.44

5Y Beta

Winner

AXSM

0.65

AGNC

0.66

Industry

AXSM

Biotechnology

AGNC

Reit - Mortgage

P/E Ratio

Winner

AXSM

-64.72

AGNC

8.00

Forward P/E

AXSM

333.33

Winner

AGNC

6.75

PEG Ratio

Winner

AXSM

0.00

AGNC

0.05

Dividend Yield

AXSM

N/A

AGNC

13.40%

5Y Dividends CAGR

AXSM

N/A

AGNC

1.61%

5Y EPS CAGR

Winner

AXSM

6.89%

AGNC

-25.22%

Debt to Equity

AXSM

344.13%

Winner

AGNC

0.00%

Free Cash Flow Yield

AXSM

-0.57%

Winner

AGNC

6.85%

P/S Ratio

AXSM

17.49

Winner

AGNC

7.87

P/B Ratio

AXSM

226.87

Winner

AGNC

1.21

AXSM vs AGNC - Historical Returns

Returns include dividend reinvestment.

Period	AXSM	AGNC
1 month	+9.97%	+9.03%
3 months	+44.99%	+12.04%
6 months	+36.72%	+7.53%
1 year	+135.12%	+34.02%
5 years(CAGR)	+29.91%	+5.19%
10 years(CAGR)	+41.72%	+6.67%
Max(CAGR)	+36.85%	+11.73%

Winner

AXSM

+9.97%

AGNC

+9.03%

Winner

AXSM

+44.99%

AGNC

+12.04%

Winner

AXSM

+36.72%

AGNC

+7.53%

Winner

AXSM

+135.12%

AGNC

+34.02%

5Y(CAGR)

Winner

AXSM

+29.91%

AGNC

+5.19%

10Y(CAGR)

Winner

AXSM

+41.72%

AGNC

+6.67%

Max(CAGR)

Winner

AXSM

+36.85%

AGNC

+11.73%

AXSM vs AGNC - Annual Returns (2008 - 2026)

Returns include dividend reinvestment.

Year	AXSM	AGNC
2026	+36.72%	+7.53%
2025	+109.16%	+33.83%
2024	+9.80%	+10.58%
2023	+8.55%	+8.86%
2022	+103.89%	-23.81%
2021	-53.61%	+6.67%
2020	-19.58%	-2.19%
2019	+3756.72%	+12.74%
2018	-48.49%	-1.28%
2017	-13.18%	+20.77%
2016	-44.63%	+15.72%
2015	+6.06%	-11.87%
2014	N/A	+26.43%
2013	N/A	-25.71%
2012	N/A	+19.74%
2011	N/A	+18.83%
2010	N/A	+31.30%
2009	N/A	+56.39%
2008	N/A	+25.51%

AXSM vs AGNC Drawdown Comparison

The maximum drawdown for AXSM was -86.65%, occurring on Dec 27, 2018. Recovery took 809 trading sessions.

The maximum drawdown for AGNC was -54.54%, occurring on Oct 10, 2022. Recovery took 1109 trading sessions.

The current AXSM drawdown is -4.26%. The current AGNC drawdown is -3.42%.

Rank	AXSM	AGNC
#1	-86.65% Jan 5, 2016 - Mar 25, 2019	-54.54% Jun 8, 2021 - Nov 5, 2025
#2	-81.26% Dec 26, 2019 - Jan 30, 2025	-51.76% Feb 20, 2020 - Apr 16, 2021
#3	-42.70% Sep 16, 2019 - Nov 19, 2019	-37.29% Apr 30, 2013 - Apr 4, 2017
#4	-30.56% Feb 21, 2025 - Nov 6, 2025	-31.04% Dec 31, 2008 - Jun 9, 2009
#5	-18.50% Jan 21, 2026 - Apr 30, 2026	-28.81% May 16, 2008 - Sep 8, 2008
#6	-17.63% Mar 25, 2019 - Apr 25, 2019	-22.42% Sep 8, 2008 - Nov 4, 2008
#7	-17.48% Jul 26, 2019 - Sep 16, 2019	-18.99% Sep 17, 2012 - Mar 28, 2013
#8	-17.26% May 28, 2019 - Jun 20, 2019	-18.68% Jan 27, 2026 - Mar 27, 2026
#9	-11.38% Jun 20, 2019 - Jun 27, 2019	-15.90% Oct 17, 2017 - Nov 7, 2019
#10	-10.33% Nov 24, 2015 - Dec 29, 2015	-15.36% Sep 23, 2009 - Mar 22, 2010
#11	-9.37% Jul 2, 2019 - Jul 26, 2019	-11.69% Jul 6, 2011 - Dec 6, 2011
#12	-8.83% Dec 4, 2019 - Dec 10, 2019	-11.06% Nov 5, 2008 - Nov 25, 2008
#13	-8.26% Dec 31, 2025 - Jan 20, 2026	-10.94% Apr 29, 2010 - Jun 14, 2010
#14	-7.23% Feb 5, 2025 - Feb 10, 2025	-10.17% Dec 3, 2008 - Dec 19, 2008
#15	-6.99% Jun 12, 2026 - Jun 25, 2026	-7.92% Apr 27, 2017 - Jun 9, 2017