AVTR vs SYRE

Comparison between Avantor Inc (AVTR, Company) and Spyre Therapeutics Inc (SYRE, Company).

Both AVTR and SYRE are from the Healthcare sector.

5-Year PerformanceSYRE has outperformed AVTR, delivering a return of -14.8% compared to -21.8%

AVTR vs SYRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AVTR(COMPANY)	SYRE(COMPANY)
Market Cap	$5.73B	$5.72B
Max Drawdown	83.16%	99.11%
Sharpe Ratio	-0.54	2.47
5Y Beta	1.07	1.74
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	-10.37	-29.38
Forward P/E	12.36	N/A
5Y EPS CAGR	N/A	-2.15%
Debt to Equity	68.29%	0.00%
Free Cash Flow Yield	7.66%	-3.25%
P/S Ratio	0.95	650.22
P/B Ratio	1.12	12.16

Market Cap

Winner

AVTR

$5.73B

SYRE

$5.72B

Max Drawdown

Winner

AVTR

83.16%

SYRE

99.11%

Sharpe Ratio

AVTR

-0.54

Winner

SYRE

2.47

5Y Beta

Winner

AVTR

1.07

SYRE

1.74

Industry

AVTR

Medical Instruments & Supplies

SYRE

Biotechnology

P/E Ratio

AVTR

-10.37

Winner

SYRE

-29.38

Forward P/E

AVTR

12.36

SYRE

N/A

5Y EPS CAGR

AVTR

N/A

SYRE

-2.15%

Debt to Equity

AVTR

68.29%

Winner

SYRE

0.00%

Free Cash Flow Yield

Winner

AVTR

7.66%

SYRE

-3.25%

P/S Ratio

Winner

AVTR

0.95

SYRE

650.22

P/B Ratio

Winner

AVTR

1.12

SYRE

12.16

AVTR vs SYRE - Historical Returns

Returns include dividend reinvestment.

Period	AVTR	SYRE
1 month	+13.66%	+3.72%
3 months	+7.39%	+81.45%
6 months	-16.29%	+120.18%
1 year	-29.34%	+343.14%
5 years(CAGR)	-21.80%	-14.82%
10 years(CAGR)	N/A	-9.03%
Max(CAGR)	-6.32%	-11.13%

Winner

AVTR

+13.66%

SYRE

+3.72%

AVTR

+7.39%

Winner

SYRE

+81.45%

AVTR

-16.29%

Winner

SYRE

+120.18%

AVTR

-29.34%

Winner

SYRE

+343.14%

5Y(CAGR)

AVTR

-21.80%

Winner

SYRE

-14.82%

10Y(CAGR)

AVTR

N/A

SYRE

-9.03%

Max(CAGR)

Winner

AVTR

-6.32%

SYRE

-11.13%

AVTR vs SYRE - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	AVTR	SYRE
2026	-20.16%	+140.84%
2025	-45.94%	+37.36%
2024	-7.38%	+8.79%
2023	+7.84%	+104.27%
2022	-48.00%	-90.57%
2021	+54.30%	-44.51%
2020	+52.57%	+1.55%
2019	+25.17%	-4.98%
2018	N/A	+39.22%
2017	N/A	+18.38%
2016	N/A	-55.48%

AVTR vs SYRE Drawdown Comparison

The maximum drawdown for AVTR was -83.16%, occurring on Mar 27, 2026. This drawdown has not yet recovered.

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The current AVTR drawdown is -79.21%. The current SYRE drawdown is -75.43%.

Rank	AVTR	SYRE
#1	-83.16% Sep 24, 2021 - Mar 27, 2026	-99.11% Apr 8, 2016 - Jun 21, 2023
#2	-57.02% Feb 6, 2020 - Jul 27, 2020	N/A
#3	-28.94% Jul 5, 2019 - Jan 17, 2020	N/A
#4	-12.58% Jan 25, 2021 - Apr 6, 2021	N/A
#5	-9.91% Apr 26, 2021 - Jun 10, 2021	N/A
#6	-9.63% Oct 22, 2020 - Nov 6, 2020	N/A
#7	-9.37% Aug 3, 2020 - Aug 31, 2020	N/A
#8	-6.60% Aug 31, 2020 - Sep 16, 2020	N/A
#9	-6.16% Nov 17, 2020 - Dec 31, 2020	N/A
#10	-5.84% Jan 11, 2021 - Jan 22, 2021	N/A
#11	-5.66% Sep 21, 2020 - Oct 1, 2020	N/A
#12	-5.00% Jan 17, 2020 - Feb 6, 2020	N/A
#13	-4.16% Apr 12, 2021 - Apr 23, 2021	N/A
#14	-3.67% May 28, 2019 - Jun 12, 2019	N/A
#15	-3.66% Oct 12, 2020 - Oct 20, 2020	N/A