APLS vs XENE

Comparison between Apellis Pharmaceuticals Inc (APLS, Company) and Xenon Pharmaceuticals Inc (XENE, Company).

Both APLS and XENE are from the Healthcare sector.

5-Year PerformanceXENE has outperformed APLS, delivering a return of +22.8% compared to -1.5%

APLS vs XENE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	APLS(COMPANY)	XENE(COMPANY)
Market Cap	$5.25B	$5.21B
Max Drawdown	82.47%	90.43%
Sharpe Ratio	1.03	1.08
5Y Beta	N/A	0.95
Industry	Biotechnology	Biotechnology
P/E Ratio	39.02	-11.58
Forward P/E	46.30	N/A
PEG Ratio	N/A	-0.28
5Y EPS CAGR	N/A	40.27%
Debt to Equity	22.59%	0.00%
Free Cash Flow Yield	0.71%	-5.90%
P/S Ratio	N/A	727.44
P/B Ratio	N/A	3.90

Market Cap

Winner

APLS

$5.25B

XENE

$5.21B

Max Drawdown

Winner

APLS

82.47%

XENE

90.43%

Sharpe Ratio

APLS

1.03

Winner

XENE

1.08

5Y Beta

APLS

N/A

XENE

0.95

Industry

APLS

Biotechnology

XENE

Biotechnology

P/E Ratio

APLS

39.02

Winner

XENE

-11.58

Forward P/E

APLS

46.30

XENE

N/A

PEG Ratio

APLS

N/A

XENE

-0.28

5Y EPS CAGR

APLS

N/A

XENE

40.27%

Debt to Equity

APLS

22.59%

Winner

XENE

0.00%

Free Cash Flow Yield

Winner

APLS

0.71%

XENE

-5.90%

P/S Ratio

APLS

N/A

XENE

727.44

P/B Ratio

APLS

N/A

XENE

3.90

APLS vs XENE - Historical Returns

Returns include dividend reinvestment.

Period	APLS	XENE
1 month	+0.44%	-10.36%
3 months	+89.08%	+23.02%
6 months	+101.82%	+14.93%
1 year	+145.69%	+68.34%
5 years(CAGR)	-1.50%	+22.76%
10 years(CAGR)	+13.44%	+21.69%
Max(CAGR)	+13.44%	+14.76%

Winner

APLS

+0.44%

XENE

-10.36%

Winner

APLS

+89.08%

XENE

+23.02%

Winner

APLS

+101.82%

XENE

+14.93%

Winner

APLS

+145.69%

XENE

+68.34%

5Y(CAGR)

APLS

-1.50%

Winner

XENE

+22.76%

10Y(CAGR)

APLS

+13.44%

Winner

XENE

+21.69%

Max(CAGR)

APLS

+13.44%

Winner

XENE

+14.76%

APLS vs XENE - Annual Returns (2014 - 2026)

Returns include dividend reinvestment.

Year	APLS	XENE
2026	+58.66%	+16.27%
2025	-24.25%	+11.58%
2024	-47.92%	-12.71%
2023	+19.05%	+23.62%
2022	+6.03%	+24.82%
2021	-13.39%	+111.94%
2020	+83.54%	+12.10%
2019	+124.82%	+96.26%
2018	-36.53%	+119.48%
2017	+54.67%	-64.01%
2016	N/A	-3.27%
2015	N/A	-57.01%
2014	N/A	+88.10%

APLS vs XENE Drawdown Comparison

The maximum drawdown for APLS was -82.47%, occurring on May 15, 2025. This drawdown has not yet recovered.

The maximum drawdown for XENE was -90.43%, occurring on Nov 14, 2017. Recovery took 1696 trading sessions.

The current APLS drawdown is -56.03%. The current XENE drawdown is -17.57%.

Rank	APLS	XENE
#1	-82.47% Jun 13, 2023 - May 15, 2025	-90.43% Jan 8, 2015 - Oct 4, 2021
#2	-61.77% Apr 16, 2018 - Sep 5, 2019	-43.59% Feb 9, 2024 - Mar 9, 2026
#3	-59.60% Feb 10, 2020 - Nov 20, 2020	-34.08% May 9, 2023 - Dec 22, 2023
#4	-55.99% Jul 2, 2021 - Apr 3, 2023	-30.14% Nov 5, 2021 - Aug 4, 2022
#5	-43.83% Jan 4, 2018 - Mar 14, 2018	-25.87% Nov 11, 2014 - Dec 11, 2014
#6	-31.32% Sep 6, 2019 - Jan 7, 2020	-17.57% Mar 9, 2026 - Jun 5, 2026
#7	-28.91% Jan 8, 2021 - Jun 1, 2021	-17.08% Mar 1, 2023 - May 3, 2023
#8	-21.52% Mar 16, 2018 - Apr 11, 2018	-16.98% Aug 24, 2022 - Feb 13, 2023
#9	-12.47% Dec 11, 2017 - Dec 21, 2017	-11.44% Oct 15, 2021 - Nov 2, 2021
#10	-8.62% May 5, 2023 - Jun 13, 2023	-11.09% Dec 11, 2014 - Dec 29, 2014
#11	-8.38% Dec 8, 2020 - Dec 15, 2020	-9.36% Feb 13, 2023 - Mar 1, 2023
#12	-8.03% Jun 14, 2021 - Jul 1, 2021	-8.58% Jan 8, 2024 - Feb 8, 2024
#13	-6.75% Apr 24, 2023 - May 5, 2023	-8.27% Aug 10, 2022 - Aug 24, 2022
#14	-6.20% Jan 21, 2020 - Feb 3, 2020	-6.08% Dec 29, 2014 - Jan 7, 2015
#15	-5.53% Nov 13, 2017 - Dec 8, 2017	-4.89% Dec 27, 2023 - Jan 8, 2024