ANVS vs RNTX

Comparison between Annovis Bio Inc (ANVS, Company) and Rein Therapeutics Inc (RNTX, Company).

Both ANVS and RNTX are from the Healthcare sector.

5-Year PerformanceRNTX has outperformed ANVS, delivering a return of -47.9% compared to -57.0%

ANVS vs RNTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ANVS(COMPANY)	RNTX(COMPANY)
Market Cap	$52M	$52M
Max Drawdown	98.99%	99.73%
Sharpe Ratio	0.01	-0.16
5Y Beta	1.62	0.88
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.09	-0.97
5Y EPS CAGR	6.84%	-37.84%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-51.37%	-37.38%
P/B Ratio	23.95	28.17

Market Cap

ANVS

$52M

Winner

RNTX

$52M

Max Drawdown

Winner

ANVS

98.99%

RNTX

99.73%

Sharpe Ratio

Winner

ANVS

0.01

RNTX

-0.16

5Y Beta

ANVS

1.62

Winner

RNTX

0.88

Industry

ANVS

Biotechnology

RNTX

Biotechnology

P/E Ratio

Winner

ANVS

-1.09

RNTX

-0.97

5Y EPS CAGR

Winner

ANVS

6.84%

RNTX

-37.84%

Debt to Equity

ANVS

0.00%

RNTX

0.00%

Free Cash Flow Yield

ANVS

-51.37%

Winner

RNTX

-37.38%

P/B Ratio

Winner

ANVS

23.95

RNTX

28.17

ANVS vs RNTX - Historical Returns

Returns include dividend reinvestment.

Period	ANVS	RNTX
1 month	+0.86%	-17.40%
3 months	-3.04%	-56.52%
6 months	-41.69%	-41.60%
1 year	-34.02%	-48.38%
5 years(CAGR)	-56.98%	-47.88%
10 years(CAGR)	N/A	-9.79%
Max(CAGR)	-23.05%	-13.30%

Winner

ANVS

+0.86%

RNTX

-17.40%

Winner

ANVS

-3.04%

RNTX

-56.52%

ANVS

-41.69%

Winner

RNTX

-41.60%

Winner

ANVS

-34.02%

RNTX

-48.38%

5Y(CAGR)

ANVS

-56.98%

Winner

RNTX

-47.88%

10Y(CAGR)

ANVS

N/A

RNTX

-9.79%

Max(CAGR)

ANVS

-23.05%

Winner

RNTX

-13.30%

ANVS vs RNTX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ANVS	RNTX
2026	-51.92%	-35.99%
2025	-32.29%	-48.44%
2024	-73.43%	-26.28%
2023	+43.96%	-4.73%
2022	-32.10%	-80.11%
2021	+115.71%	-46.39%
2020	-21.38%	+74.79%
2019	N/A	-43.82%
2018	N/A	-92.02%
2017	N/A	+9302.32%
2016	N/A	+0.00%
2015	N/A	+0.00%
2014	N/A	+0.00%
2013	N/A	-77.52%
2012	N/A	-71.66%
2011	N/A	-22.46%
2010	N/A	+215.48%
2009	N/A	+21.67%
2008	N/A	-31.03%
2007	N/A	-56.50%
2006	N/A	+12.00%
2005	N/A	-14.85%
2004	N/A	-11.90%
2003	N/A	+70.25%
2002	N/A	+1.94%
2001	N/A	-31.11%
2000	N/A	+12.12%
1999	N/A	+13.79%

ANVS vs RNTX Drawdown Comparison

The maximum drawdown for ANVS was -98.99%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for RNTX was -99.73%, occurring on Jul 23, 2026. This drawdown has not yet recovered.

The current ANVS drawdown is -98.55%. The current RNTX drawdown is -99.73%.

Rank	ANVS	RNTX
#1	-98.99% Jul 13, 2021 - Apr 8, 2025	-99.73% Oct 4, 2017 - Jul 23, 2026
#2	-73.93% Jan 29, 2020 - Jan 13, 2021	-97.95% Feb 17, 2004 - Jun 29, 2017
#3	-43.94% Mar 17, 2021 - May 21, 2021	-64.00% Mar 20, 2000 - Feb 9, 2004
#4	-25.67% May 21, 2021 - Jun 3, 2021	-26.17% Jan 4, 2000 - Mar 14, 2000
#5	-25.05% Feb 22, 2021 - Mar 15, 2021	-18.78% Sep 7, 2017 - Oct 2, 2017
#6	-17.86% Jun 21, 2021 - Jul 2, 2021	-17.25% Jul 7, 2017 - Sep 7, 2017
#7	-13.29% Feb 4, 2021 - Feb 9, 2021	-16.15% Nov 2, 1999 - Nov 12, 1999
#8	-6.06% Jun 8, 2021 - Jun 10, 2021	-13.14% Dec 21, 1999 - Jan 4, 2000
#9	-5.95% Jan 26, 2021 - Feb 2, 2021	-11.43% Nov 22, 1999 - Dec 3, 1999
#10	-5.61% Jun 16, 2021 - Jun 21, 2021	-10.81% Dec 9, 1999 - Dec 21, 1999
#11	-5.47% Jul 8, 2021 - Jul 12, 2021	-3.85% Mar 14, 2000 - Mar 17, 2000
#12	-5.16% Jun 11, 2021 - Jun 16, 2021	-3.05% Nov 15, 1999 - Nov 22, 1999
#13	-2.06% Mar 15, 2021 - Mar 17, 2021	-2.53% Feb 10, 2004 - Feb 17, 2004
#14	-1.24% Jan 14, 2021 - Jan 21, 2021	-2.30% Jul 3, 2017 - Jul 6, 2017
#15	-0.43% Jan 22, 2021 - Jan 26, 2021	-0.07% Oct 2, 2017 - Oct 4, 2017