ALNY vs MSTR

Comparison between Alnylam Pharmaceuticals Inc (ALNY, Company) and Microstrategy Inc - Class A (MSTR, Company).

ALNY is from the Healthcare sector, while MSTR is from the Technology sector.

5-Year PerformanceMSTR has outperformed ALNY, delivering a return of +15.8% compared to +11.6%

ALNY vs MSTR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ALNY(COMPANY)	MSTR(COMPANY)
Market Cap	$39B	$39B
Max Drawdown	83.58%	99.86%
Sharpe Ratio	-0.07	-1.30
5Y Beta	0.80	2.47
Industry	Biotechnology	Software - Application
P/E Ratio	123.07	-14.78
Forward P/E	30.30	1.60
PEG Ratio	0.51	-0.13
Debt to Equity	0.00%	22.36%
Free Cash Flow Yield	1.21%	-0.15%
P/S Ratio	9.27	84.30
P/B Ratio	36.96	1.13

Market Cap

Winner

ALNY

$39B

MSTR

$39B

Max Drawdown

Winner

ALNY

83.58%

MSTR

99.86%

Sharpe Ratio

Winner

ALNY

-0.07

MSTR

-1.30

5Y Beta

Winner

ALNY

0.80

MSTR

2.47

Industry

ALNY

Biotechnology

MSTR

Software - Application

P/E Ratio

ALNY

123.07

Winner

MSTR

-14.78

Forward P/E

ALNY

30.30

Winner

MSTR

1.60

PEG Ratio

ALNY

0.51

Winner

MSTR

-0.13

Debt to Equity

Winner

ALNY

0.00%

MSTR

22.36%

Free Cash Flow Yield

Winner

ALNY

1.21%

MSTR

-0.15%

P/S Ratio

Winner

ALNY

9.27

MSTR

84.30

P/B Ratio

ALNY

36.96

Winner

MSTR

1.13

ALNY vs MSTR - Historical Returns

Returns include dividend reinvestment.

Period	ALNY	MSTR
1 month	+0.29%	-26.08%
3 months	-9.76%	-11.10%
6 months	-26.49%	-19.09%
1 year	-6.79%	-65.69%
5 years(CAGR)	+11.57%	+15.77%
10 years(CAGR)	+17.15%	+21.65%
Max(CAGR)	+18.37%	+3.77%

Winner

ALNY

+0.29%

MSTR

-26.08%

Winner

ALNY

-9.76%

MSTR

-11.10%

ALNY

-26.49%

Winner

MSTR

-19.09%

Winner

ALNY

-6.79%

MSTR

-65.69%

5Y(CAGR)

ALNY

+11.57%

Winner

MSTR

+15.77%

10Y(CAGR)

ALNY

+17.15%

Winner

MSTR

+21.65%

Max(CAGR)

Winner

ALNY

+18.37%

MSTR

+3.77%

ALNY vs MSTR - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ALNY	MSTR
2026	-28.08%	-16.56%
2025	+70.21%	-49.35%
2024	+20.72%	+322.71%
2023	-18.06%	+335.54%
2022	+36.65%	-74.64%
2021	+32.38%	+28.05%
2020	+12.41%	+169.25%
2019	+58.29%	+10.94%
2018	-44.70%	-3.07%
2017	+228.80%	-33.63%
2016	-59.75%	+15.35%
2015	-3.71%	+9.91%
2014	+51.89%	+31.47%
2013	+235.42%	+30.11%
2012	+110.74%	-16.09%
2011	-18.58%	+22.58%
2010	-45.64%	-11.12%
2009	-29.94%	+152.20%
2008	-14.49%	-58.78%
2007	+34.82%	-17.58%
2006	+65.12%	+31.03%
2005	+76.25%	+41.44%
2004	+6.71%	+16.43%
2003	N/A	+230.27%
2002	N/A	-61.18%
2001	N/A	-59.47%
2000	N/A	-90.89%
1999	N/A	+114.55%

ALNY vs MSTR Drawdown Comparison

The maximum drawdown for ALNY was -83.58%, occurring on Oct 3, 2011. Recovery took 1443 trading sessions.

The maximum drawdown for MSTR was -99.86%, occurring on Jul 26, 2002. Recovery took 6207 trading sessions.

The current ALNY drawdown is -41.41%. The current MSTR drawdown is -72.32%.

Rank	ALNY	MSTR
#1	-83.58% Oct 9, 2007 - Jul 3, 2013	-99.86% Mar 10, 2000 - Nov 11, 2024
#2	-77.36% Jun 22, 2015 - Nov 10, 2017	-77.42% Nov 20, 2024 - Feb 5, 2026
#3	-57.81% Mar 20, 2018 - Jun 19, 2020	-29.10% Dec 10, 1999 - Jan 10, 2000
#4	-52.18% Jun 9, 2004 - Jan 6, 2005	-20.42% Feb 16, 2000 - Mar 1, 2000
#5	-47.61% Jan 13, 2014 - Oct 24, 2014	-17.27% Nov 3, 1999 - Nov 22, 1999
#6	-42.46% Oct 14, 2021 - Aug 3, 2022	-14.35% Jan 28, 2000 - Feb 8, 2000
#7	-42.42% Oct 20, 2025 - Jun 12, 2026	-9.76% Nov 29, 1999 - Dec 3, 1999
#8	-40.61% Dec 21, 2022 - Jun 26, 2024	-9.65% Jan 10, 2000 - Jan 19, 2000
#9	-36.52% Mar 29, 2006 - Oct 31, 2006	-8.11% Nov 12, 2024 - Nov 18, 2024
#10	-36.33% Dec 8, 2006 - Jul 11, 2007	-7.59% Dec 6, 1999 - Dec 8, 1999
#11	-34.67% Sep 12, 2005 - Jan 10, 2006	-2.15% Nov 22, 1999 - Nov 24, 1999
#12	-32.55% Jan 10, 2005 - Sep 7, 2005	-2.12% Jan 21, 2000 - Jan 26, 2000
#13	-26.79% Jan 25, 2021 - Jun 18, 2021	-0.86% Mar 7, 2000 - Mar 9, 2000
#14	-26.77% Jul 20, 2020 - Jan 12, 2021	-0.71% Feb 8, 2000 - Feb 10, 2000
#15	-25.36% Oct 16, 2024 - May 30, 2025	N/A