ALGN vs MDGL

Comparison between Align Technology Inc (ALGN, Company) and Madrigal Pharmaceuticals Inc (MDGL, Company).

Both ALGN and MDGL are from the Healthcare sector.

5-Year PerformanceMDGL has outperformed ALGN, delivering a return of +31.3% compared to -22.4%

ALGN vs MDGL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ALGN(COMPANY)	MDGL(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	92.30%	98.40%
Sharpe Ratio	0.20	1.33
5Y Beta	1.33	0.73
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	29.07	-39.71
Forward P/E	14.86	666.67
PEG Ratio	3.51	0.00
5Y EPS CAGR	0.63%	23.26%
Debt to Equity	0.00%	62.62%
Free Cash Flow Yield	4.69%	-2.20%
P/S Ratio	3.04	10.99
P/B Ratio	2.91	19.84

Market Cap

Winner

ALGN

$12B

MDGL

$12B

Max Drawdown

Winner

ALGN

92.30%

MDGL

98.40%

Sharpe Ratio

ALGN

0.20

Winner

MDGL

1.33

5Y Beta

ALGN

1.33

Winner

MDGL

0.73

Industry

ALGN

Medical Instruments & Supplies

MDGL

Biotechnology

P/E Ratio

ALGN

29.07

Winner

MDGL

-39.71

Forward P/E

Winner

ALGN

14.86

MDGL

666.67

PEG Ratio

ALGN

3.51

Winner

MDGL

0.00

5Y EPS CAGR

ALGN

0.63%

Winner

MDGL

23.26%

Debt to Equity

Winner

ALGN

0.00%

MDGL

62.62%

Free Cash Flow Yield

Winner

ALGN

4.69%

MDGL

-2.20%

P/S Ratio

Winner

ALGN

3.04

MDGL

10.99

P/B Ratio

Winner

ALGN

2.91

MDGL

19.84

ALGN vs MDGL - Historical Returns

Returns include dividend reinvestment.

Period	ALGN	MDGL
1 month	-4.55%	-1.87%
3 months	-12.32%	+4.46%
6 months	+25.17%	+4.25%
1 year	-6.72%	+70.26%
5 years(CAGR)	-22.35%	+31.34%
10 years(CAGR)	+8.37%	+44.03%
Max(CAGR)	+9.54%	+2.48%

ALGN

-4.55%

Winner

MDGL

-1.87%

ALGN

-12.32%

Winner

MDGL

+4.46%

Winner

ALGN

+25.17%

MDGL

+4.25%

ALGN

-6.72%

Winner

MDGL

+70.26%

5Y(CAGR)

ALGN

-22.35%

Winner

MDGL

+31.34%

10Y(CAGR)

ALGN

+8.37%

Winner

MDGL

+44.03%

Max(CAGR)

Winner

ALGN

+9.54%

MDGL

+2.48%

ALGN vs MDGL - Annual Returns (2001 - 2026)

Returns include dividend reinvestment.

Year	ALGN	MDGL
2026	+8.17%	-14.12%
2025	-25.10%	+85.59%
2024	-22.46%	+36.02%
2023	+29.07%	-18.93%
2022	-67.46%	+222.07%
2021	+24.83%	-22.80%
2020	+88.37%	+22.60%
2019	+38.06%	-18.06%
2018	-6.76%	+15.71%
2017	+129.16%	+475.13%
2016	+49.57%	+28.97%
2015	+17.17%	-87.74%
2014	-1.84%	-49.62%
2013	+101.20%	-45.64%
2012	+15.87%	+84.46%
2011	+19.40%	-24.56%
2010	+5.62%	+10.87%
2009	+100.45%	-17.99%
2008	-46.87%	-3.62%
2007	+24.94%	-26.29%
2006	+122.45%	N/A
2005	-38.73%	N/A
2004	-35.59%	N/A
2003	+502.77%	N/A
2002	-35.79%	N/A
2001	-73.34%	N/A

ALGN vs MDGL Drawdown Comparison

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The current ALGN drawdown is -76.88%. The current MDGL drawdown is -15.39%.

Rank	ALGN	MDGL
#1	-92.30% Jan 30, 2001 - Nov 3, 2003	-98.40% Jan 28, 2013 - Aug 22, 2025
#2	-82.89% Sep 8, 2021 - Sep 25, 2025	-87.64% Oct 5, 2007 - Jan 22, 2013
#3	-82.58% Oct 24, 2007 - Apr 24, 2012	-51.43% Jun 4, 2007 - Oct 4, 2007
#4	-75.18% Apr 19, 2004 - Apr 26, 2007	-29.36% Dec 22, 2025 - Mar 3, 2026
#5	-64.95% Sep 25, 2018 - Oct 22, 2020	-18.88% Feb 9, 2007 - Jun 4, 2007
#6	-35.18% Sep 13, 2012 - Jul 10, 2013	-10.10% Sep 30, 2025 - Nov 5, 2025
#7	-30.62% Jan 17, 2014 - Jun 16, 2015	-9.42% Nov 26, 2025 - Dec 22, 2025
#8	-22.28% Jan 26, 2018 - May 11, 2018	-8.01% Sep 8, 2025 - Sep 30, 2025
#9	-20.05% Feb 5, 2021 - Apr 27, 2021	-4.91% Nov 11, 2025 - Nov 17, 2025
#10	-18.56% Jul 25, 2007 - Oct 4, 2007	-4.32% Jan 23, 2013 - Jan 25, 2013
#11	-18.32% Jul 20, 2015 - Oct 23, 2015	-3.02% Nov 18, 2025 - Nov 24, 2025
#12	-17.71% Jan 26, 2004 - Apr 12, 2004	-1.52% Aug 29, 2025 - Sep 8, 2025
#13	-17.21% Nov 28, 2017 - Jan 17, 2018	-0.59% Aug 22, 2025 - Aug 26, 2025
#14	-14.67% Dec 1, 2003 - Jan 7, 2004	N/A
#15	-14.09% Oct 26, 2015 - Mar 2, 2016	N/A