ALGN vs MDGL

Comparison between Align Technology Inc (ALGN, Company) and Madrigal Pharmaceuticals Inc (MDGL, Company).

Both ALGN and MDGL are from the Healthcare sector.

5-Year PerformanceMDGL has outperformed ALGN, delivering a return of +43.0% compared to -23.5%

ALGN vs MDGL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ALGN(COMPANY)	MDGL(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	92.30%	98.40%
Sharpe Ratio	0.65	0.83
5Y Beta	1.30	0.68
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	30.08	-37.76
Forward P/E	15.58	666.67
PEG Ratio	0.83	-3.48
5Y EPS CAGR	-8.14%	21.71%
Debt to Equity	0.00%	65.07%
Free Cash Flow Yield	5.11%	-1.67%
P/S Ratio	3.11	9.13
P/B Ratio	2.96	22.38

Market Cap

Winner

ALGN

$12B

MDGL

$12B

Max Drawdown

Winner

ALGN

92.30%

MDGL

98.40%

Sharpe Ratio

ALGN

0.65

Winner

MDGL

0.83

5Y Beta

ALGN

1.30

Winner

MDGL

0.68

Industry

ALGN

Medical Instruments & Supplies

MDGL

Biotechnology

P/E Ratio

ALGN

30.08

Winner

MDGL

-37.76

Forward P/E

Winner

ALGN

15.58

MDGL

666.67

PEG Ratio

ALGN

0.83

Winner

MDGL

-3.48

5Y EPS CAGR

ALGN

-8.14%

Winner

MDGL

21.71%

Debt to Equity

Winner

ALGN

0.00%

MDGL

65.07%

Free Cash Flow Yield

Winner

ALGN

5.11%

MDGL

-1.67%

P/S Ratio

Winner

ALGN

3.11

MDGL

9.13

P/B Ratio

Winner

ALGN

2.96

MDGL

22.38

ALGN vs MDGL - Historical Returns

Returns include dividend reinvestment.

Period	ALGN	MDGL
1 month	+1.60%	-5.46%
3 months	+12.94%	-5.99%
6 months	-2.92%	+9.22%
1 year	+26.90%	+36.67%
5 years(CAGR)	-23.47%	+42.99%
10 years(CAGR)	+6.57%	+51.21%
Max(CAGR)	+9.74%	+2.42%

Winner

ALGN

+1.60%

MDGL

-5.46%

Winner

ALGN

+12.94%

MDGL

-5.99%

ALGN

-2.92%

Winner

MDGL

+9.22%

ALGN

+26.90%

Winner

MDGL

+36.67%

5Y(CAGR)

ALGN

-23.47%

Winner

MDGL

+42.99%

10Y(CAGR)

ALGN

+6.57%

Winner

MDGL

+51.21%

Max(CAGR)

Winner

ALGN

+9.74%

MDGL

+2.42%

ALGN vs MDGL - Annual Returns (2001 - 2026)

Returns include dividend reinvestment.

Year	ALGN	MDGL
2026	+16.20%	-14.53%
2025	-25.10%	+85.59%
2024	-22.46%	+36.02%
2023	+29.07%	-18.93%
2022	-67.46%	+222.07%
2021	+24.83%	-22.80%
2020	+88.37%	+22.60%
2019	+38.06%	-18.06%
2018	-6.76%	+15.71%
2017	+129.16%	+475.13%
2016	+49.57%	+28.97%
2015	+17.17%	-87.74%
2014	-1.84%	-49.62%
2013	+101.20%	-45.64%
2012	+15.87%	+84.46%
2011	+19.40%	-24.56%
2010	+5.62%	+10.87%
2009	+100.45%	-17.99%
2008	-46.87%	-3.62%
2007	+24.94%	-26.29%
2006	+122.45%	N/A
2005	-38.73%	N/A
2004	-35.59%	N/A
2003	+502.77%	N/A
2002	-35.79%	N/A
2001	-73.34%	N/A

ALGN vs MDGL Drawdown Comparison

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The maximum drawdown for MDGL was -98.40%, occurring on Feb 11, 2016. Recovery took 3162 trading sessions.

The current ALGN drawdown is -75.16%. The current MDGL drawdown is -15.80%.

Rank	ALGN	MDGL
#1	-92.30% Jan 30, 2001 - Nov 3, 2003	-98.40% Jan 28, 2013 - Aug 22, 2025
#2	-82.89% Sep 8, 2021 - Sep 25, 2025	-87.64% Oct 5, 2007 - Jan 22, 2013
#3	-82.58% Oct 24, 2007 - Apr 24, 2012	-51.43% Jun 4, 2007 - Oct 4, 2007
#4	-75.18% Apr 19, 2004 - Apr 26, 2007	-29.36% Dec 22, 2025 - Mar 3, 2026
#5	-64.95% Sep 25, 2018 - Oct 22, 2020	-18.88% Feb 9, 2007 - Jun 4, 2007
#6	-35.18% Sep 13, 2012 - Jul 10, 2013	-10.10% Sep 30, 2025 - Nov 5, 2025
#7	-30.62% Jan 17, 2014 - Jun 16, 2015	-9.42% Nov 26, 2025 - Dec 22, 2025
#8	-22.28% Jan 26, 2018 - May 11, 2018	-8.01% Sep 8, 2025 - Sep 30, 2025
#9	-20.05% Feb 5, 2021 - Apr 27, 2021	-4.91% Nov 11, 2025 - Nov 17, 2025
#10	-18.56% Jul 25, 2007 - Oct 4, 2007	-4.32% Jan 23, 2013 - Jan 25, 2013
#11	-18.32% Jul 20, 2015 - Oct 23, 2015	-3.02% Nov 18, 2025 - Nov 24, 2025
#12	-17.71% Jan 26, 2004 - Apr 12, 2004	-1.52% Aug 29, 2025 - Sep 8, 2025
#13	-17.21% Nov 28, 2017 - Jan 17, 2018	-0.59% Aug 22, 2025 - Aug 26, 2025
#14	-14.67% Dec 1, 2003 - Jan 7, 2004	N/A
#15	-14.09% Oct 26, 2015 - Mar 2, 2016	N/A