ALGN vs AXSM

Comparison between Align Technology Inc (ALGN, Company) and Axsome Therapeutics Inc (AXSM, Company).

Both ALGN and AXSM are from the Healthcare sector.

5-Year PerformanceAXSM has outperformed ALGN, delivering a return of +26.9% compared to -21.9%

ALGN vs AXSM - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ALGN(COMPANY)	AXSM(COMPANY)
Market Cap	$12B	$12B
Max Drawdown	92.30%	86.65%
Sharpe Ratio	0.15	2.14
5Y Beta	1.34	0.65
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	28.56	-63.99
Forward P/E	15.70	333.33
PEG Ratio	3.44	0.00
5Y EPS CAGR	0.63%	6.89%
Debt to Equity	0.00%	344.13%
Free Cash Flow Yield	4.77%	-0.58%
P/S Ratio	2.99	17.49
P/B Ratio	2.91	224.29

Market Cap

Winner

ALGN

$12B

AXSM

$12B

Max Drawdown

ALGN

92.30%

Winner

AXSM

86.65%

Sharpe Ratio

ALGN

0.15

Winner

AXSM

2.14

5Y Beta

ALGN

1.34

Winner

AXSM

0.65

Industry

ALGN

Medical Instruments & Supplies

AXSM

Biotechnology

P/E Ratio

ALGN

28.56

Winner

AXSM

-63.99

Forward P/E

Winner

ALGN

15.70

AXSM

333.33

PEG Ratio

ALGN

3.44

Winner

AXSM

0.00

5Y EPS CAGR

ALGN

0.63%

Winner

AXSM

6.89%

Debt to Equity

Winner

ALGN

0.00%

AXSM

344.13%

Free Cash Flow Yield

Winner

ALGN

4.77%

AXSM

-0.58%

P/S Ratio

Winner

ALGN

2.99

AXSM

17.49

P/B Ratio

Winner

ALGN

2.91

AXSM

224.29

ALGN vs AXSM - Historical Returns

Returns include dividend reinvestment.

Period	ALGN	AXSM
1 month	+9.10%	+3.19%
3 months	+0.62%	+47.12%
6 months	+12.67%	+58.94%
1 year	-4.96%	+135.61%
5 years(CAGR)	-21.92%	+26.87%
10 years(CAGR)	+8.74%	+41.26%
Max(CAGR)	+9.73%	+36.77%

Winner

ALGN

+9.10%

AXSM

+3.19%

ALGN

+0.62%

Winner

AXSM

+47.12%

ALGN

+12.67%

Winner

AXSM

+58.94%

ALGN

-4.96%

Winner

AXSM

+135.61%

5Y(CAGR)

ALGN

-21.92%

Winner

AXSM

+26.87%

10Y(CAGR)

ALGN

+8.74%

Winner

AXSM

+41.26%

Max(CAGR)

ALGN

+9.73%

Winner

AXSM

+36.77%

ALGN vs AXSM - Annual Returns (2001 - 2026)

Returns include dividend reinvestment.

Year	ALGN	AXSM
2026	+14.36%	+35.25%
2025	-25.10%	+109.16%
2024	-22.46%	+9.80%
2023	+29.07%	+8.55%
2022	-67.46%	+103.89%
2021	+24.83%	-53.61%
2020	+88.37%	-19.58%
2019	+38.06%	+3756.72%
2018	-6.76%	-48.49%
2017	+129.16%	-13.18%
2016	+49.57%	-44.63%
2015	+17.17%	+6.06%
2014	-1.84%	N/A
2013	+101.20%	N/A
2012	+15.87%	N/A
2011	+19.40%	N/A
2010	+5.62%	N/A
2009	+100.45%	N/A
2008	-46.87%	N/A
2007	+24.94%	N/A
2006	+122.45%	N/A
2005	-38.73%	N/A
2004	-35.59%	N/A
2003	+502.77%	N/A
2002	-35.79%	N/A
2001	-73.34%	N/A

ALGN vs AXSM Drawdown Comparison

The maximum drawdown for ALGN was -92.30%, occurring on Nov 13, 2002. Recovery took 692 trading sessions.

The maximum drawdown for AXSM was -86.65%, occurring on Dec 27, 2018. Recovery took 809 trading sessions.

The current ALGN drawdown is -75.55%. The current AXSM drawdown is -5.29%.

Rank	ALGN	AXSM
#1	-92.30% Jan 30, 2001 - Nov 3, 2003	-86.65% Jan 5, 2016 - Mar 25, 2019
#2	-82.89% Sep 8, 2021 - Sep 25, 2025	-81.26% Dec 26, 2019 - Jan 30, 2025
#3	-82.58% Oct 24, 2007 - Apr 24, 2012	-42.70% Sep 16, 2019 - Nov 19, 2019
#4	-75.18% Apr 19, 2004 - Apr 26, 2007	-30.56% Feb 21, 2025 - Nov 6, 2025
#5	-64.95% Sep 25, 2018 - Oct 22, 2020	-18.50% Jan 21, 2026 - Apr 30, 2026
#6	-35.18% Sep 13, 2012 - Jul 10, 2013	-17.63% Mar 25, 2019 - Apr 25, 2019
#7	-30.62% Jan 17, 2014 - Jun 16, 2015	-17.48% Jul 26, 2019 - Sep 16, 2019
#8	-22.28% Jan 26, 2018 - May 11, 2018	-17.26% May 28, 2019 - Jun 20, 2019
#9	-20.05% Feb 5, 2021 - Apr 27, 2021	-11.38% Jun 20, 2019 - Jun 27, 2019
#10	-18.56% Jul 25, 2007 - Oct 4, 2007	-10.33% Nov 24, 2015 - Dec 29, 2015
#11	-18.32% Jul 20, 2015 - Oct 23, 2015	-9.37% Jul 2, 2019 - Jul 26, 2019
#12	-17.71% Jan 26, 2004 - Apr 12, 2004	-8.83% Dec 4, 2019 - Dec 10, 2019
#13	-17.21% Nov 28, 2017 - Jan 17, 2018	-8.26% Dec 31, 2025 - Jan 20, 2026
#14	-14.67% Dec 1, 2003 - Jan 7, 2004	-7.23% Feb 5, 2025 - Feb 10, 2025
#15	-14.09% Oct 26, 2015 - Mar 2, 2016	-6.99% Jun 12, 2026 - Jun 25, 2026