ACAD vs DNLI

Comparison between Acadia Pharmaceuticals Inc (ACAD, Company) and Denali Therapeutics Inc (DNLI, Company).

Both ACAD and DNLI are from the Healthcare sector.

5-Year PerformanceACAD has outperformed DNLI, delivering a return of -3.6% compared to -20.6%

ACAD vs DNLI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ACAD(COMPANY)	DNLI(COMPANY)
Market Cap	$3.70B	$3.70B
Max Drawdown	96.29%	87.74%
Sharpe Ratio	-0.06	1.11
5Y Beta	0.92	1.51
Industry	Biotechnology	Biotechnology
P/E Ratio	9.78	-6.96
Forward P/E	60.61	N/A
PEG Ratio	0.16	-1.09
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	3.07%	-11.41%

Market Cap

Winner

ACAD

$3.70B

DNLI

$3.70B

Max Drawdown

ACAD

96.29%

Winner

DNLI

87.74%

Sharpe Ratio

ACAD

-0.06

Winner

DNLI

1.11

5Y Beta

Winner

ACAD

0.92

DNLI

1.51

Industry

ACAD

Biotechnology

DNLI

Biotechnology

P/E Ratio

ACAD

9.78

Winner

DNLI

-6.96

Forward P/E

ACAD

60.61

DNLI

N/A

PEG Ratio

ACAD

0.16

Winner

DNLI

-1.09

Debt to Equity

ACAD

0.00%

DNLI

0.00%

Free Cash Flow Yield

Winner

ACAD

3.07%

DNLI

-11.41%

ACAD vs DNLI - Historical Returns

Returns include dividend reinvestment.

Period	ACAD	DNLI
1 month	+4.49%	+26.68%
3 months	+6.40%	+16.20%
6 months	-18.72%	+39.00%
1 year	-5.80%	+65.44%
5 years(CAGR)	-3.65%	-20.57%
10 years(CAGR)	-5.33%	+0.98%
Max(CAGR)	+5.45%	+0.98%

ACAD

+4.49%

Winner

DNLI

+26.68%

ACAD

+6.40%

Winner

DNLI

+16.20%

ACAD

-18.72%

Winner

DNLI

+39.00%

ACAD

-5.80%

Winner

DNLI

+65.44%

5Y(CAGR)

Winner

ACAD

-3.65%

DNLI

-20.57%

10Y(CAGR)

ACAD

-5.33%

Winner

DNLI

+0.98%

Max(CAGR)

Winner

ACAD

+5.45%

DNLI

+0.98%

ACAD vs DNLI - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	ACAD	DNLI
2026	-17.76%	+43.27%
2025	+43.14%	-20.78%
2024	-40.54%	-4.72%
2023	+91.85%	-22.33%
2022	-34.73%	-41.17%
2021	-55.80%	-37.06%
2020	+30.04%	+411.04%
2019	+156.94%	-9.88%
2018	-46.86%	+28.08%
2017	+4.66%	-27.09%
2016	-16.70%	N/A
2015	+14.45%	N/A
2014	+26.24%	N/A
2013	+428.33%	N/A
2012	+318.92%	N/A
2011	-11.48%	N/A
2010	-11.76%	N/A
2009	+18.92%	N/A
2008	-91.71%	N/A
2007	+26.23%	N/A
2006	-12.01%	N/A
2005	+54.15%	N/A
2004	+1.04%	N/A

ACAD vs DNLI Drawdown Comparison

The maximum drawdown for ACAD was -96.29%, occurring on Nov 12, 2010. Recovery took 1820 trading sessions.

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current ACAD drawdown is -62.07%. The current DNLI drawdown is -75.09%.

Rank	ACAD	DNLI
#1	-96.29% Mar 16, 2006 - Jun 10, 2013	-87.74% Dec 22, 2020 - Apr 8, 2025
#2	-77.18% Jul 7, 2020 - Jun 21, 2022	-49.76% Feb 16, 2018 - Apr 2, 2019
#3	-73.99% Jul 17, 2015 - Dec 5, 2019	-49.54% Apr 10, 2019 - Jun 2, 2020
#4	-40.80% Feb 27, 2014 - Dec 2, 2014	-29.88% Dec 8, 2017 - Jan 22, 2018
#5	-38.42% Dec 6, 2019 - Apr 27, 2020	-19.74% Jun 3, 2020 - Aug 6, 2020
#6	-33.81% Mar 10, 2015 - Jul 14, 2015	-19.58% Jan 29, 2018 - Feb 16, 2018
#7	-31.14% Oct 2, 2013 - Feb 25, 2014	-13.33% Nov 12, 2020 - Dec 4, 2020
#8	-25.79% Sep 15, 2004 - Feb 8, 2005	-11.16% Aug 10, 2020 - Aug 25, 2020
#9	-25.26% Jun 17, 2004 - Sep 1, 2004	-10.43% Sep 17, 2020 - Oct 7, 2020
#10	-23.54% Oct 19, 2005 - Jan 31, 2006	-10.33% Oct 13, 2020 - Oct 27, 2020
#11	-21.59% Feb 9, 2005 - May 24, 2005	-9.64% Aug 25, 2020 - Sep 14, 2020
#12	-14.01% May 20, 2020 - Jun 23, 2020	-7.28% Oct 28, 2020 - Nov 4, 2020
#13	-13.93% Jun 10, 2013 - Jul 15, 2013	-3.20% Jan 23, 2018 - Jan 26, 2018
#14	-13.41% Apr 27, 2020 - May 18, 2020	-2.37% Apr 3, 2019 - Apr 5, 2019
#15	-13.09% Jun 16, 2005 - Jul 20, 2005	-1.33% Dec 16, 2020 - Dec 18, 2020