XLO vs DRRX

Comparison between Xilio Therapeutics Inc (XLO, Company) and Durect Corp (DRRX, Company).

Both XLO and DRRX are from the Healthcare sector.

5-Year PerformanceDRRX has outperformed XLO, delivering a return of -34.6% compared to -48.5%

XLO vs DRRX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	XLO(COMPANY)	DRRX(COMPANY)
Market Cap	$60M	$60M
Max Drawdown	98.01%	99.68%
Sharpe Ratio	-0.04	0.66
5Y Beta	0.78	N/A
Industry	Biotechnology	Drug Manufacturers - Specialty & Generic
P/E Ratio	-1.91	-17.21
5Y EPS CAGR	-46.63%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	N/A	-23.46%
P/S Ratio	1.13	-49.64
P/B Ratio	0.83	17.09

Market Cap

Winner

XLO

$60M

DRRX

$60M

Max Drawdown

Winner

XLO

98.01%

DRRX

99.68%

Sharpe Ratio

XLO

-0.04

Winner

DRRX

0.66

5Y Beta

XLO

0.78

DRRX

N/A

Industry

XLO

Biotechnology

DRRX

Drug Manufacturers - Specialty & Generic

P/E Ratio

XLO

-1.91

Winner

DRRX

-17.21

5Y EPS CAGR

XLO

-46.63%

DRRX

N/A

Debt to Equity

XLO

0.00%

DRRX

0.00%

Free Cash Flow Yield

XLO

N/A

DRRX

-23.46%

P/S Ratio

XLO

1.13

Winner

DRRX

-49.64

P/B Ratio

Winner

XLO

0.83

DRRX

17.09

XLO vs DRRX - Historical Returns

Returns include dividend reinvestment.

Period	XLO	DRRX
1 month	+1.55%	+2.14%
3 months	+4.09%	+218.33%
6 months	+12.89%	+133.38%
1 year	-6.79%	+21.66%
5 years(CAGR)	-48.54%	-34.63%
10 years(CAGR)	N/A	-22.33%
Max(CAGR)	-48.54%	-15.91%

XLO

+1.55%

Winner

DRRX

+2.14%

XLO

+4.09%

Winner

DRRX

+218.33%

XLO

+12.89%

Winner

DRRX

+133.38%

XLO

-6.79%

Winner

DRRX

+21.66%

5Y(CAGR)

XLO

-48.54%

Winner

DRRX

-34.63%

10Y(CAGR)

XLO

N/A

DRRX

-22.33%

Max(CAGR)

XLO

-48.54%

Winner

DRRX

-15.91%

XLO vs DRRX - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	XLO	DRRX
2026	-2.49%	N/A
2025	-40.17%	+141.53%
2024	+66.09%	+35.14%
2023	-79.55%	-83.61%
2022	-83.24%	-64.51%
2021	+0.00%	-53.05%
2020	N/A	-20.99%
2019	N/A	+603.44%
2018	N/A	-47.49%
2017	N/A	-31.34%
2016	N/A	-34.31%
2015	N/A	+166.27%
2014	N/A	-54.38%
2013	N/A	+80.21%
2012	N/A	-23.33%
2011	N/A	-67.13%
2010	N/A	+34.77%
2009	N/A	-25.15%
2008	N/A	-45.41%
2007	N/A	+46.47%
2006	N/A	-12.43%
2005	N/A	+62.50%
2004	N/A	+24.24%
2003	N/A	+17.92%
2002	N/A	-81.72%
2001	N/A	+4.13%
2000	N/A	-16.72%

XLO vs DRRX Drawdown Comparison

The maximum drawdown for XLO was -98.01%, occurring on Dec 20, 2023. This drawdown has not yet recovered.

The maximum drawdown for DRRX was -99.68%, occurring on May 27, 2025. This drawdown has not yet recovered.

The current XLO drawdown is -97.39%. The current DRRX drawdown is -98.79%.

Rank	XLO	DRRX
#1	-98.01% Nov 16, 2021 - Dec 20, 2023	-99.68% Nov 6, 2000 - May 27, 2025
#2	-15.07% Nov 2, 2021 - Nov 4, 2021	-23.81% Oct 6, 2000 - Nov 6, 2000
#3	-7.66% Nov 4, 2021 - Nov 8, 2021	-8.73% Sep 29, 2000 - Oct 6, 2000
#4	-6.89% Nov 8, 2021 - Nov 16, 2021	N/A
#5	-2.19% Oct 26, 2021 - Oct 29, 2021	N/A