UPB vs PRTC

Comparison between Upstream Bio Inc (UPB, Company) and PureTech Health plc American Depositary Shares (PRTC, Company).

Both UPB and PRTC are from the Healthcare sector.

UPB vs PRTC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	UPB(COMPANY)	PRTC(COMPANY)
Market Cap	$376M	$377M
Max Drawdown	81.84%	78.91%
Sharpe Ratio	-0.07	-0.03
5Y Beta	1.10	N/A
Industry	Biotechnology	Biotechnology
P/E Ratio	-2.39	-11.67
5Y EPS CAGR	N/A	-28.22%
Debt to Equity	0.00%	5.56%
Free Cash Flow Yield	-37.25%	-58.22%
P/S Ratio	107.96	59.84
P/B Ratio	1.25	1.00

Market Cap

UPB

$376M

Winner

PRTC

$377M

Max Drawdown

UPB

81.84%

Winner

PRTC

78.91%

Sharpe Ratio

UPB

-0.07

Winner

PRTC

-0.03

5Y Beta

UPB

1.10

PRTC

N/A

Industry

UPB

Biotechnology

PRTC

Biotechnology

P/E Ratio

UPB

-2.39

Winner

PRTC

-11.67

5Y EPS CAGR

UPB

N/A

PRTC

-28.22%

Debt to Equity

Winner

UPB

0.00%

PRTC

5.56%

Free Cash Flow Yield

Winner

UPB

-37.25%

PRTC

-58.22%

P/S Ratio

UPB

107.96

Winner

PRTC

59.84

P/B Ratio

UPB

1.25

Winner

PRTC

1.00

UPB vs PRTC - Historical Returns

Returns include dividend reinvestment.

Period	UPB	PRTC
1 month	+1.27%	+0.00%
3 months	-33.33%	-1.91%
6 months	-78.68%	-6.04%
1 year	-44.49%	-6.09%
5 years(CAGR)	N/A	-18.35%
Max(CAGR)	-50.03%	-13.03%

Winner

UPB

+1.27%

PRTC

+0.00%

UPB

-33.33%

Winner

PRTC

-1.91%

UPB

-78.68%

Winner

PRTC

-6.04%

UPB

-44.49%

Winner

PRTC

-6.09%

5Y(CAGR)

UPB

N/A

PRTC

-18.35%

Max(CAGR)

UPB

-50.03%

Winner

PRTC

-13.03%

UPB vs PRTC - Annual Returns (2020 - 2026)

Returns include dividend reinvestment.

Year	UPB	PRTC
2026	-76.36%	+4.69%
2025	+66.56%	-14.59%
2024	-25.27%	-26.16%
2023	N/A	-11.66%
2022	N/A	-13.78%
2021	N/A	-34.51%
2020	N/A	+40.26%

UPB vs PRTC Drawdown Comparison

The maximum drawdown for UPB was -81.84%, occurring on Jun 16, 2026. This drawdown has not yet recovered.

The maximum drawdown for PRTC was -78.91%, occurring on Apr 10, 2025. This drawdown has not yet recovered.

The current UPB drawdown is -80.37%. The current PRTC drawdown is -72.78%.

Rank	UPB	PRTC
#1	-81.84% Jan 13, 2026 - Jun 16, 2026	-78.91% Mar 29, 2021 - Apr 10, 2025
#2	-77.84% Nov 5, 2024 - Nov 25, 2025	-18.35% Jan 7, 2021 - Mar 29, 2021
#3	-14.99% Dec 22, 2025 - Jan 12, 2026	-4.66% Nov 17, 2020 - Dec 2, 2020
#4	-13.70% Dec 1, 2025 - Dec 16, 2025	-0.97% Jan 4, 2021 - Jan 7, 2021
#5	-6.45% Oct 21, 2024 - Nov 5, 2024	-0.88% Dec 7, 2020 - Dec 10, 2020
#6	-3.38% Dec 16, 2025 - Dec 18, 2025	N/A
#7	-2.88% Nov 25, 2025 - Dec 1, 2025	N/A
#8	-1.71% Dec 18, 2025 - Dec 22, 2025	N/A
#9	-1.63% Oct 14, 2024 - Oct 16, 2024	N/A
#10	-0.13% Oct 16, 2024 - Oct 18, 2024	N/A