TWST vs KNSA

Comparison between Twist Bioscience Corp (TWST, Company) and Kiniksa Pharmaceuticals International plc. - Class A (KNSA, Company).

Both TWST and KNSA are from the Healthcare sector.

5-Year PerformanceKNSA has outperformed TWST, delivering a return of +29.4% compared to -6.4%

TWST vs KNSA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	TWST(COMPANY)	KNSA(COMPANY)
Market Cap	$3.99B	$3.97B
Max Drawdown	94.48%	83.06%
Sharpe Ratio	1.51	1.31
5Y Beta	2.01	0.57
Industry	Diagnostics & Research	Drug Manufacturers - Specialty & Generic
P/E Ratio	-42.10	57.45
Forward P/E	N/A	44.84
5Y EPS CAGR	-10.29%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-2.20%	4.14%
P/S Ratio	10.17	4.94
P/B Ratio	9.15	6.15

Market Cap

Winner

TWST

$3.99B

KNSA

$3.97B

Max Drawdown

TWST

94.48%

Winner

KNSA

83.06%

Sharpe Ratio

Winner

TWST

1.51

KNSA

1.31

5Y Beta

TWST

2.01

Winner

KNSA

0.57

Industry

TWST

Diagnostics & Research

KNSA

Drug Manufacturers - Specialty & Generic

P/E Ratio

Winner

TWST

-42.10

KNSA

57.45

Forward P/E

TWST

N/A

KNSA

44.84

5Y EPS CAGR

TWST

-10.29%

KNSA

N/A

Debt to Equity

TWST

0.00%

KNSA

0.00%

Free Cash Flow Yield

TWST

-2.20%

Winner

KNSA

4.14%

P/S Ratio

TWST

10.17

Winner

KNSA

4.94

P/B Ratio

TWST

9.15

Winner

KNSA

6.15

TWST vs KNSA - Historical Returns

Returns include dividend reinvestment.

Period	TWST	KNSA
1 month	+22.08%	-14.66%
3 months	+42.25%	+5.22%
6 months	+114.30%	+16.20%
1 year	+128.22%	+64.02%
5 years(CAGR)	-6.40%	+29.40%
10 years(CAGR)	N/A	+12.01%
Max(CAGR)	+23.42%	+12.01%

Winner

TWST

+22.08%

KNSA

-14.66%

Winner

TWST

+42.25%

KNSA

+5.22%

Winner

TWST

+114.30%

KNSA

+16.20%

Winner

TWST

+128.22%

KNSA

+64.02%

5Y(CAGR)

TWST

-6.40%

Winner

KNSA

+29.40%

10Y(CAGR)

TWST

N/A

KNSA

+12.01%

Max(CAGR)

Winner

TWST

+23.42%

KNSA

+12.01%

TWST vs KNSA - Annual Returns (2018 - 2026)

Returns include dividend reinvestment.

Year	TWST	KNSA
2026	+113.71%	+15.27%
2025	-29.99%	+106.87%
2024	+34.15%	+6.75%
2023	+54.81%	+21.47%
2022	-71.41%	+21.10%
2021	-41.78%	-31.05%
2020	+577.65%	+57.91%
2019	-14.15%	-58.41%
2018	+64.93%	+44.27%

TWST vs KNSA Drawdown Comparison

The maximum drawdown for TWST was -94.48%, occurring on May 2, 2023. This drawdown has not yet recovered.

The maximum drawdown for KNSA was -83.06%, occurring on Oct 18, 2019. Recovery took 1724 trading sessions.

The current TWST drawdown is -66.72%. The current KNSA drawdown is -18.59%.

Rank	TWST	KNSA
#1	-94.48% Jan 20, 2021 - May 2, 2023	-83.06% Sep 20, 2018 - Aug 1, 2025
#2	-47.55% Dec 6, 2018 - Apr 23, 2019	-34.99% Jun 20, 2018 - Aug 29, 2018
#3	-43.93% Mar 6, 2020 - May 6, 2020	-21.12% May 12, 2026 - Jun 2, 2026
#4	-38.66% Jul 30, 2019 - Mar 6, 2020	-14.33% Apr 6, 2026 - Apr 28, 2026
#5	-34.52% Apr 24, 2019 - Jul 29, 2019	-13.47% Sep 10, 2018 - Sep 19, 2018
#6	-23.28% Oct 15, 2020 - Nov 11, 2020	-12.87% Dec 22, 2025 - Jan 27, 2026
#7	-20.82% Dec 22, 2020 - Jan 11, 2021	-12.12% May 24, 2018 - Jun 20, 2018
#8	-17.62% Nov 16, 2018 - Dec 4, 2018	-10.49% Feb 20, 2026 - Mar 31, 2026
#9	-16.33% Aug 5, 2020 - Aug 17, 2020	-8.84% Oct 27, 2025 - Nov 17, 2025
#10	-14.98% Nov 23, 2020 - Dec 1, 2020	-6.18% Nov 25, 2025 - Dec 19, 2025
#11	-13.94% Sep 1, 2020 - Sep 25, 2020	-5.29% Feb 3, 2026 - Feb 11, 2026
#12	-13.60% May 18, 2020 - Jun 22, 2020	-4.64% Sep 30, 2025 - Oct 15, 2025
#13	-9.92% Nov 9, 2018 - Nov 15, 2018	-4.53% Sep 12, 2025 - Sep 29, 2025
#14	-8.54% Dec 10, 2020 - Dec 22, 2020	-3.05% Jan 27, 2026 - Feb 2, 2026
#15	-8.25% Jul 9, 2020 - Jul 20, 2020	-2.90% Aug 7, 2025 - Aug 13, 2025