SPRB vs PMN

Comparison between Spruce Biosciences Inc (SPRB, Company) and ProMIS Neurosciences Inc (PMN, Company).

Both SPRB and PMN are from the Healthcare sector.

5-Year PerformanceSPRB has outperformed PMN, delivering a return of -39.0% compared to -41.8%

SPRB vs PMN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SPRB(COMPANY)	PMN(COMPANY)
Market Cap	$130M	$130M
Max Drawdown	99.81%	99.69%
Sharpe Ratio	0.97	0.49
5Y Beta	1.62	0.46
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.17	-0.76
PEG Ratio	N/A	-0.00
5Y EPS CAGR	-18.04%	N/A
Debt to Equity	8.47%	0.00%
Free Cash Flow Yield	-33.01%	-27.36%
P/S Ratio	49.19	4016.22
P/B Ratio	3.66	2.17

Market Cap

SPRB

$130M

Winner

PMN

$130M

Max Drawdown

SPRB

99.81%

Winner

PMN

99.69%

Sharpe Ratio

Winner

SPRB

0.97

PMN

0.49

5Y Beta

SPRB

1.62

Winner

PMN

0.46

Industry

SPRB

Biotechnology

PMN

Biotechnology

P/E Ratio

Winner

SPRB

-1.17

PMN

-0.76

PEG Ratio

SPRB

N/A

PMN

-0.00

5Y EPS CAGR

SPRB

-18.04%

PMN

N/A

Debt to Equity

SPRB

8.47%

Winner

PMN

0.00%

Free Cash Flow Yield

SPRB

-33.01%

Winner

PMN

-27.36%

P/S Ratio

Winner

SPRB

49.19

PMN

4016.22

P/B Ratio

SPRB

3.66

Winner

PMN

2.17

SPRB vs PMN - Historical Returns

Returns include dividend reinvestment.

Period	SPRB	PMN
1 month	+16.82%	-1.09%
3 months	+0.91%	+40.66%
6 months	+4.56%	-7.33%
1 year	+521.09%	+13.62%
5 years(CAGR)	-38.98%	-41.82%
10 years(CAGR)	N/A	-21.78%
Max(CAGR)	-42.07%	-22.70%

Winner

SPRB

+16.82%

PMN

-1.09%

SPRB

+0.91%

Winner

PMN

+40.66%

Winner

SPRB

+4.56%

PMN

-7.33%

Winner

SPRB

+521.09%

PMN

+13.62%

5Y(CAGR)

Winner

SPRB

-38.98%

PMN

-41.82%

10Y(CAGR)

SPRB

N/A

PMN

-21.78%

Max(CAGR)

SPRB

-42.07%

Winner

PMN

-22.70%

SPRB vs PMN - Annual Returns (2007 - 2026)

Returns include dividend reinvestment.

Year	SPRB	PMN
2026	-42.68%	+108.97%
2025	+176.94%	-71.56%
2024	-85.81%	-31.79%
2023	+154.78%	-74.44%
2022	-76.09%	-39.72%
2021	-80.40%	+37.50%
2020	+43.00%	-40.79%
2019	N/A	-38.36%
2018	N/A	+24.33%
2017	N/A	+41.67%
2016	N/A	+179.45%
2015	N/A	-74.83%
2014	N/A	-51.18%
2013	N/A	-15.78%
2012	N/A	+48.08%
2011	N/A	-37.20%
2010	N/A	-32.90%
2009	N/A	+20.40%
2008	N/A	-62.40%
2007	N/A	-10.70%

SPRB vs PMN Drawdown Comparison

The maximum drawdown for SPRB was -99.81%, occurring on Jun 9, 2025. This drawdown has not yet recovered.

The maximum drawdown for PMN was -99.69%, occurring on Nov 28, 2025. This drawdown has not yet recovered.

The current SPRB drawdown is -97.86%. The current PMN drawdown is -99.31%.

Rank	SPRB	PMN
#1	-99.81% Nov 27, 2020 - Jun 9, 2025	-99.69% Jul 31, 2007 - Nov 28, 2025
#2	-20.38% Oct 29, 2020 - Nov 13, 2020	-7.75% Jul 17, 2007 - Jul 20, 2007
#3	-13.84% Oct 14, 2020 - Oct 23, 2020	N/A
#4	-2.56% Nov 20, 2020 - Nov 27, 2020	N/A
#5	-2.16% Nov 16, 2020 - Nov 18, 2020	N/A