SPRB vs BYSI

Comparison between Spruce Biosciences Inc (SPRB, Company) and BeyondSpring Inc (BYSI, Company).

Both SPRB and BYSI are from the Healthcare sector.

5-Year PerformanceBYSI has outperformed SPRB, delivering a return of -32.8% compared to -43.1%

SPRB vs BYSI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SPRB(COMPANY)	BYSI(COMPANY)
Market Cap	$68M	$68M
Max Drawdown	99.81%	98.83%
Sharpe Ratio	1.02	-0.16
5Y Beta	1.61	0.71
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.31	-8.80
Forward P/E	N/A	10.54
PEG Ratio	N/A	-0.08
5Y EPS CAGR	-12.70%	N/A
Debt to Equity	18.66%	0.00%
Free Cash Flow Yield	-43.18%	-27.78%
P/S Ratio	49.19	45.99
P/B Ratio	3.85	5.38

Market Cap

Winner

SPRB

$68M

BYSI

$68M

Max Drawdown

SPRB

99.81%

Winner

BYSI

98.83%

Sharpe Ratio

Winner

SPRB

1.02

BYSI

-0.16

5Y Beta

SPRB

1.61

Winner

BYSI

0.71

Industry

SPRB

Biotechnology

BYSI

Biotechnology

P/E Ratio

SPRB

-1.31

Winner

BYSI

-8.80

Forward P/E

SPRB

N/A

BYSI

10.54

PEG Ratio

SPRB

N/A

BYSI

-0.08

5Y EPS CAGR

SPRB

-12.70%

BYSI

N/A

Debt to Equity

SPRB

18.66%

Winner

BYSI

0.00%

Free Cash Flow Yield

SPRB

-43.18%

Winner

BYSI

-27.78%

P/S Ratio

SPRB

49.19

Winner

BYSI

45.99

P/B Ratio

Winner

SPRB

3.85

BYSI

5.38

SPRB vs BYSI - Historical Returns

Returns include dividend reinvestment.

Period	SPRB	BYSI
1 month	-8.43%	+12.95%
3 months	-13.37%	-3.68%
6 months	-37.78%	-25.59%
1 year	+792.73%	-44.52%
5 years(CAGR)	-43.12%	-32.76%
10 years(CAGR)	N/A	-22.58%
Max(CAGR)	-43.13%	-22.58%

SPRB

-8.43%

Winner

BYSI

+12.95%

SPRB

-13.37%

Winner

BYSI

-3.68%

SPRB

-37.78%

Winner

BYSI

-25.59%

Winner

SPRB

+792.73%

BYSI

-44.52%

5Y(CAGR)

SPRB

-43.12%

Winner

BYSI

-32.76%

10Y(CAGR)

SPRB

N/A

BYSI

-22.58%

Max(CAGR)

SPRB

-43.13%

Winner

BYSI

-22.58%

SPRB vs BYSI - Annual Returns (2017 - 2026)

Returns include dividend reinvestment.

Year	SPRB	BYSI
2026	-42.79%	-2.48%
2025	+176.94%	+2.52%
2024	-85.81%	+90.42%
2023	+154.78%	-48.57%
2022	-76.09%	-62.48%
2021	-80.40%	-62.75%
2020	+43.00%	-21.29%
2019	N/A	-16.40%
2018	N/A	-35.34%
2017	N/A	+73.09%

SPRB vs BYSI Drawdown Comparison

The maximum drawdown for SPRB was -99.81%, occurring on Jun 9, 2025. This drawdown has not yet recovered.

The maximum drawdown for BYSI was -98.83%, occurring on Dec 8, 2022. This drawdown has not yet recovered.

The current SPRB drawdown is -97.87%. The current BYSI drawdown is -96.75%.

Rank	SPRB	BYSI
#1	-99.81% Nov 27, 2020 - Jun 9, 2025	-98.83% Jul 3, 2017 - Dec 8, 2022
#2	-20.38% Oct 29, 2020 - Nov 13, 2020	-31.39% Jun 6, 2017 - Jul 3, 2017
#3	-13.84% Oct 14, 2020 - Oct 23, 2020	-6.91% Mar 13, 2017 - Mar 17, 2017
#4	-2.56% Nov 20, 2020 - Nov 27, 2020	-6.57% Mar 17, 2017 - Mar 31, 2017
#5	-2.16% Nov 16, 2020 - Nov 18, 2020	-4.33% May 4, 2017 - May 16, 2017
#6	N/A	-1.97% May 16, 2017 - May 18, 2017
#7	N/A	-1.44% Apr 27, 2017 - May 2, 2017
#8	N/A	-0.85% Mar 31, 2017 - Apr 7, 2017
#9	N/A	-0.75% Apr 7, 2017 - Apr 13, 2017
#10	N/A	-0.60% Apr 21, 2017 - Apr 26, 2017
#11	N/A	-0.51% Apr 19, 2017 - Apr 21, 2017
#12	N/A	-0.39% May 25, 2017 - May 30, 2017