SLN vs PRME

Comparison between Silence Therapeutics Plc (SLN, Company) and Prime Medicine Inc (PRME, Company).

Both SLN and PRME are from the Healthcare sector.

SLN vs PRME - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SLN(COMPANY)	PRME(COMPANY)
Market Cap	$559M	$558M
Max Drawdown	92.31%	94.55%
Sharpe Ratio	1.16	-0.03
5Y Beta	0.90	2.10
Industry	Biotechnology	Biotechnology
P/E Ratio	-7.45	-2.58
PEG Ratio	-1.69	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-11.74%	-28.44%

Market Cap

Winner

SLN

$559M

PRME

$558M

Max Drawdown

Winner

SLN

92.31%

PRME

94.55%

Sharpe Ratio

Winner

SLN

1.16

PRME

-0.03

5Y Beta

Winner

SLN

0.90

PRME

2.10

Industry

SLN

Biotechnology

PRME

Biotechnology

P/E Ratio

Winner

SLN

-7.45

PRME

-2.58

PEG Ratio

SLN

-1.69

PRME

N/A

Debt to Equity

SLN

0.00%

PRME

0.00%

Free Cash Flow Yield

Winner

SLN

-11.74%

PRME

-28.44%

SLN vs PRME - Historical Returns

Returns include dividend reinvestment.

Period	SLN	PRME
1 month	+57.50%	-8.33%
3 months	+46.05%	-22.66%
6 months	+101.94%	-32.96%
1 year	+86.18%	-35.99%
5 years(CAGR)	-14.47%	N/A
Max(CAGR)	-8.67%	-35.44%

Winner

SLN

+57.50%

PRME

-8.33%

Winner

SLN

+46.05%

PRME

-22.66%

Winner

SLN

+101.94%

PRME

-32.96%

Winner

SLN

+86.18%

PRME

-35.99%

5Y(CAGR)

SLN

-14.47%

PRME

N/A

Max(CAGR)

Winner

SLN

-8.67%

PRME

-35.44%

SLN vs PRME - Annual Returns (2020 - 2026)

Returns include dividend reinvestment.

Year	SLN	PRME
2026	+86.18%	-15.86%
2025	-15.44%	+16.05%
2024	-62.91%	-66.67%
2023	+18.24%	-49.49%
2022	-36.17%	+20.88%
2021	-0.46%	N/A
2020	+12.82%	N/A

SLN vs PRME Drawdown Comparison

The maximum drawdown for SLN was -92.31%, occurring on Apr 9, 2025. This drawdown has not yet recovered.

The maximum drawdown for PRME was -94.55%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The current SLN drawdown is -59.61%. The current PRME drawdown is -85.94%.

Rank	SLN	PRME
#1	-92.31% Jun 28, 2021 - Apr 9, 2025	-94.55% Nov 1, 2022 - Apr 8, 2025
#2	-23.08% Sep 8, 2020 - Nov 9, 2020	-3.55% Oct 21, 2022 - Oct 25, 2022
#3	-20.24% Feb 22, 2021 - Jun 11, 2021	N/A
#4	-16.46% Nov 9, 2020 - Dec 23, 2020	N/A
#5	-9.17% Jan 4, 2021 - Jan 22, 2021	N/A
#6	-8.45% Jun 11, 2021 - Jun 28, 2021	N/A
#7	-4.59% Jan 27, 2021 - Feb 17, 2021	N/A
#8	-2.85% Jan 22, 2021 - Jan 26, 2021	N/A
#9	-2.61% Feb 18, 2021 - Feb 22, 2021	N/A