SEPN vs GSL

Comparison between Septerna Inc (SEPN, Company) and Global Ship Lease Inc - Class A (GSL, Company).

SEPN is from the Healthcare sector, while GSL is from the Industrials sector.

SEPN vs GSL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SEPN(COMPANY)	GSL(COMPANY)
Market Cap	$1.54B	$1.54B
Max Drawdown	81.47%	95.58%
Sharpe Ratio	1.78	1.76
5Y Beta	1.25	0.81
Industry	Biotechnology	Marine Shipping
P/E Ratio	-42.42	3.91
Forward P/E	107.53	3.11
PEG Ratio	N/A	0.87
Dividend Yield	N/A	5.71%
5Y Dividends CAGR	N/A	63.54%
5Y EPS CAGR	N/A	35.09%
Debt to Equity	0.00%	34.81%
Free Cash Flow Yield	6.96%	26.26%
P/S Ratio	21.34	2.00
P/B Ratio	4.02	0.81

Market Cap

SEPN

$1.54B

Winner

GSL

$1.54B

Max Drawdown

Winner

SEPN

81.47%

GSL

95.58%

Sharpe Ratio

Winner

SEPN

1.78

GSL

1.76

5Y Beta

SEPN

1.25

Winner

GSL

0.81

Industry

SEPN

Biotechnology

GSL

Marine Shipping

P/E Ratio

Winner

SEPN

-42.42

GSL

3.91

Forward P/E

SEPN

107.53

Winner

GSL

3.11

PEG Ratio

SEPN

N/A

GSL

0.87

Dividend Yield

SEPN

N/A

GSL

5.71%

5Y Dividends CAGR

SEPN

N/A

GSL

63.54%

5Y EPS CAGR

SEPN

N/A

GSL

35.09%

Debt to Equity

Winner

SEPN

0.00%

GSL

34.81%

Free Cash Flow Yield

SEPN

6.96%

Winner

GSL

26.26%

P/S Ratio

SEPN

21.34

Winner

GSL

2.00

P/B Ratio

SEPN

4.02

Winner

GSL

0.81

SEPN vs GSL - Historical Returns

Returns include dividend reinvestment.

Period	SEPN	GSL
1 month	-8.48%	+10.19%
3 months	+34.04%	+16.14%
6 months	+29.90%	+23.09%
1 year	+147.38%	+59.51%
5 years(CAGR)	N/A	+29.46%
10 years(CAGR)	N/A	+17.94%
Max(CAGR)	+29.29%	+1.43%

SEPN

-8.48%

Winner

GSL

+10.19%

Winner

SEPN

+34.04%

GSL

+16.14%

Winner

SEPN

+29.90%

GSL

+23.09%

Winner

SEPN

+147.38%

GSL

+59.51%

5Y(CAGR)

SEPN

N/A

GSL

+29.46%

10Y(CAGR)

SEPN

N/A

GSL

+17.94%

Max(CAGR)

Winner

SEPN

+29.29%

GSL

+1.43%

SEPN vs GSL - Annual Returns (2008 - 2026)

Returns include dividend reinvestment.

Year	SEPN	GSL
2026	+19.62%	+27.22%
2025	+30.59%	+66.82%
2024	+7.01%	+18.15%
2023	N/A	+29.34%
2022	N/A	-23.41%
2021	N/A	+102.68%
2020	N/A	+38.10%
2019	N/A	+58.79%
2018	N/A	-47.46%
2017	N/A	-25.16%
2016	N/A	-42.31%
2015	N/A	-41.54%
2014	N/A	-22.81%
2013	N/A	+95.77%
2012	N/A	+68.00%
2011	N/A	-64.16%
2010	N/A	+241.38%
2009	N/A	-55.55%
2008	N/A	-57.93%

SEPN vs GSL Drawdown Comparison

The maximum drawdown for SEPN was -81.47%, occurring on Apr 1, 2025. Recovery took 230 trading sessions.

The maximum drawdown for GSL was -95.25%, occurring on Mar 19, 2020. Recovery took 3774 trading sessions.

The current SEPN drawdown is -11.55%.

Rank	SEPN	GSL
#1	-81.47% Dec 23, 2024 - Nov 24, 2025	-95.25% Feb 23, 2011 - Feb 26, 2026
#2	-25.18% Feb 24, 2026 - May 28, 2026	-83.31% Aug 15, 2008 - Jan 19, 2011
#3	-21.10% Dec 19, 2025 - Feb 17, 2026	-12.51% Mar 2, 2026 - May 5, 2026
#4	-16.77% Dec 4, 2024 - Dec 23, 2024	-12.44% May 8, 2026 - Jul 16, 2026
#5	-16.60% Jul 9, 2026 - Jul 16, 2026	-4.83% Jan 21, 2011 - Jan 27, 2011
#6	-16.19% Nov 7, 2024 - Dec 4, 2024	-3.53% Jul 16, 2026 - Jul 21, 2026
#7	-13.97% Nov 26, 2025 - Dec 19, 2025	-3.15% Jan 27, 2011 - Feb 9, 2011
#8	-10.63% Feb 17, 2026 - Feb 24, 2026	-1.13% Feb 14, 2011 - Feb 22, 2011
#9	-10.36% Jun 26, 2026 - Jul 9, 2026	-0.62% Jan 19, 2011 - Jan 21, 2011
#10	-6.45% Oct 25, 2024 - Oct 31, 2024	-0.19% May 6, 2026 - May 8, 2026
#11	-5.55% Jun 23, 2026 - Jun 26, 2026	N/A
#12	-4.76% Oct 31, 2024 - Nov 4, 2024	N/A
#13	-3.65% Jun 18, 2026 - Jun 23, 2026	N/A
#14	-3.57% May 28, 2026 - Jun 4, 2026	N/A
#15	-3.45% Nov 4, 2024 - Nov 6, 2024	N/A