SCLX vs DRRX

Comparison between Scilex Holding Company (SCLX, Company) and Durect Corp (DRRX, Company).

Both SCLX and DRRX are from the Healthcare sector.

5-Year PerformanceDRRX has outperformed SCLX, delivering a return of -34.6% compared to -49.9%

SCLX vs DRRX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SCLX(COMPANY)	DRRX(COMPANY)
Market Cap	$60M	$60M
Max Drawdown	99.23%	99.68%
Sharpe Ratio	0.53	0.66
5Y Beta	1.02	N/A
Industry	Drug Manufacturers - General	Drug Manufacturers - Specialty & Generic
P/E Ratio	-0.16	-17.21
Forward P/E	2.66	N/A
PEG Ratio	-0.00	N/A
Debt to Equity	-32.41%	0.00%
Free Cash Flow Yield	-5.75%	-23.46%
P/S Ratio	1.53	-49.64
P/B Ratio	28.85	17.09

Market Cap

Winner

SCLX

$60M

DRRX

$60M

Max Drawdown

Winner

SCLX

99.23%

DRRX

99.68%

Sharpe Ratio

SCLX

0.53

Winner

DRRX

0.66

5Y Beta

SCLX

1.02

DRRX

N/A

Industry

SCLX

Drug Manufacturers - General

DRRX

Drug Manufacturers - Specialty & Generic

P/E Ratio

SCLX

-0.16

Winner

DRRX

-17.21

Forward P/E

SCLX

2.66

DRRX

N/A

PEG Ratio

SCLX

-0.00

DRRX

N/A

Debt to Equity

Winner

SCLX

-32.41%

DRRX

0.00%

Free Cash Flow Yield

Winner

SCLX

-5.75%

DRRX

-23.46%

P/S Ratio

SCLX

1.53

Winner

DRRX

-49.64

P/B Ratio

SCLX

28.85

Winner

DRRX

17.09

SCLX vs DRRX - Historical Returns

Returns include dividend reinvestment.

Period	SCLX	DRRX
1 month	-0.29%	+2.14%
3 months	+64.20%	+218.33%
6 months	-0.05%	+133.38%
1 year	+2.47%	+21.66%
5 years(CAGR)	-49.89%	-34.63%
10 years(CAGR)	N/A	-22.33%
Max(CAGR)	-47.27%	-15.91%

SCLX

-0.29%

Winner

DRRX

+2.14%

SCLX

+64.20%

Winner

DRRX

+218.33%

SCLX

-0.05%

Winner

DRRX

+133.38%

SCLX

+2.47%

Winner

DRRX

+21.66%

5Y(CAGR)

SCLX

-49.89%

Winner

DRRX

-34.63%

10Y(CAGR)

SCLX

N/A

DRRX

-22.33%

Max(CAGR)

SCLX

-47.27%

Winner

DRRX

-15.91%

SCLX vs DRRX - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	SCLX	DRRX
2026	-16.08%	N/A
2025	-20.13%	+141.53%
2024	-79.10%	+35.14%
2023	-61.61%	-83.61%
2022	-60.30%	-64.51%
2021	+1.93%	-53.05%
2020	N/A	-20.99%
2019	N/A	+603.44%
2018	N/A	-47.49%
2017	N/A	-31.34%
2016	N/A	-34.31%
2015	N/A	+166.27%
2014	N/A	-54.38%
2013	N/A	+80.21%
2012	N/A	-23.33%
2011	N/A	-67.13%
2010	N/A	+34.77%
2009	N/A	-25.15%
2008	N/A	-45.41%
2007	N/A	+46.47%
2006	N/A	-12.43%
2005	N/A	+62.50%
2004	N/A	+24.24%
2003	N/A	+17.92%
2002	N/A	-81.72%
2001	N/A	+4.13%
2000	N/A	-16.72%

SCLX vs DRRX Drawdown Comparison

The maximum drawdown for SCLX was -99.23%, occurring on Apr 22, 2025. This drawdown has not yet recovered.

The maximum drawdown for DRRX was -99.68%, occurring on May 27, 2025. This drawdown has not yet recovered.

The current SCLX drawdown is -97.88%. The current DRRX drawdown is -98.79%.

Rank	SCLX	DRRX
#1	-99.23% Apr 12, 2023 - Apr 22, 2025	-99.68% Nov 6, 2000 - May 27, 2025
#2	-72.67% Nov 8, 2022 - Jan 19, 2023	-23.81% Oct 6, 2000 - Nov 6, 2000
#3	-42.23% Jan 20, 2023 - Apr 5, 2023	-8.73% Sep 29, 2000 - Oct 6, 2000
#4	-16.08% Oct 26, 2022 - Nov 8, 2022	N/A
#5	-8.13% Apr 10, 2023 - Apr 12, 2023	N/A
#6	-1.26% Jun 27, 2022 - Oct 13, 2022	N/A
#7	-1.21% Mar 11, 2021 - Apr 19, 2021	N/A
#8	-0.80% Apr 19, 2021 - Aug 30, 2021	N/A
#9	-0.59% Nov 2, 2021 - Jan 24, 2022	N/A
#10	-0.50% Oct 18, 2021 - Nov 2, 2021	N/A
#11	-0.40% Jan 24, 2022 - Feb 2, 2022	N/A
#12	-0.39% Mar 17, 2022 - May 4, 2022	N/A
#13	-0.29% May 5, 2022 - May 25, 2022	N/A
#14	-0.29% May 27, 2022 - Jun 21, 2022	N/A
#15	-0.28% Sep 14, 2021 - Oct 14, 2021	N/A