PRTC vs UPB

Comparison between PureTech Health plc American Depositary Shares (PRTC, Company) and Upstream Bio Inc (UPB, Company).

Both PRTC and UPB are from the Healthcare sector.

PRTC vs UPB - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PRTC(COMPANY)	UPB(COMPANY)
Market Cap	$377M	$376M
Max Drawdown	78.91%	81.84%
Sharpe Ratio	-0.03	-0.07
5Y Beta	N/A	1.10
Industry	Biotechnology	Biotechnology
P/E Ratio	-11.67	-2.39
5Y EPS CAGR	-28.22%	N/A
Debt to Equity	5.56%	0.00%
Free Cash Flow Yield	-58.22%	-37.25%
P/S Ratio	59.84	107.96
P/B Ratio	1.00	1.25

Market Cap

Winner

PRTC

$377M

UPB

$376M

Max Drawdown

Winner

PRTC

78.91%

UPB

81.84%

Sharpe Ratio

Winner

PRTC

-0.03

UPB

-0.07

5Y Beta

PRTC

N/A

UPB

1.10

Industry

PRTC

Biotechnology

UPB

Biotechnology

P/E Ratio

Winner

PRTC

-11.67

UPB

-2.39

5Y EPS CAGR

PRTC

-28.22%

UPB

N/A

Debt to Equity

PRTC

5.56%

Winner

UPB

0.00%

Free Cash Flow Yield

PRTC

-58.22%

Winner

UPB

-37.25%

P/S Ratio

Winner

PRTC

59.84

UPB

107.96

P/B Ratio

Winner

PRTC

1.00

UPB

1.25

PRTC vs UPB - Historical Returns

Returns include dividend reinvestment.

Period	PRTC	UPB
1 month	+0.00%	+1.27%
3 months	-1.91%	-33.33%
6 months	-6.04%	-78.68%
1 year	-6.09%	-44.49%
5 years(CAGR)	-18.35%	N/A
Max(CAGR)	-13.03%	-50.03%

PRTC

+0.00%

Winner

UPB

+1.27%

Winner

PRTC

-1.91%

UPB

-33.33%

Winner

PRTC

-6.04%

UPB

-78.68%

Winner

PRTC

-6.09%

UPB

-44.49%

5Y(CAGR)

PRTC

-18.35%

UPB

N/A

Max(CAGR)

Winner

PRTC

-13.03%

UPB

-50.03%

PRTC vs UPB - Annual Returns (2020 - 2026)

Returns include dividend reinvestment.

Year	PRTC	UPB
2026	+4.69%	-76.36%
2025	-14.59%	+66.56%
2024	-26.16%	-25.27%
2023	-11.66%	N/A
2022	-13.78%	N/A
2021	-34.51%	N/A
2020	+40.26%	N/A

PRTC vs UPB Drawdown Comparison

The maximum drawdown for PRTC was -78.91%, occurring on Apr 10, 2025. This drawdown has not yet recovered.

The maximum drawdown for UPB was -81.84%, occurring on Jun 16, 2026. This drawdown has not yet recovered.

The current PRTC drawdown is -72.78%. The current UPB drawdown is -80.37%.

Rank	PRTC	UPB
#1	-78.91% Mar 29, 2021 - Apr 10, 2025	-81.84% Jan 13, 2026 - Jun 16, 2026
#2	-18.35% Jan 7, 2021 - Mar 29, 2021	-77.84% Nov 5, 2024 - Nov 25, 2025
#3	-4.66% Nov 17, 2020 - Dec 2, 2020	-14.99% Dec 22, 2025 - Jan 12, 2026
#4	-0.97% Jan 4, 2021 - Jan 7, 2021	-13.70% Dec 1, 2025 - Dec 16, 2025
#5	-0.88% Dec 7, 2020 - Dec 10, 2020	-6.45% Oct 21, 2024 - Nov 5, 2024
#6	N/A	-3.38% Dec 16, 2025 - Dec 18, 2025
#7	N/A	-2.88% Nov 25, 2025 - Dec 1, 2025
#8	N/A	-1.71% Dec 18, 2025 - Dec 22, 2025
#9	N/A	-1.63% Oct 14, 2024 - Oct 16, 2024
#10	N/A	-0.13% Oct 16, 2024 - Oct 18, 2024