PMN vs SPRB

Comparison between ProMIS Neurosciences Inc (PMN, Company) and Spruce Biosciences Inc (SPRB, Company).

Both PMN and SPRB are from the Healthcare sector.

5-Year PerformanceSPRB has outperformed PMN, delivering a return of -39.0% compared to -41.8%

PMN vs SPRB - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PMN(COMPANY)	SPRB(COMPANY)
Market Cap	$130M	$130M
Max Drawdown	99.69%	99.81%
Sharpe Ratio	0.49	0.97
5Y Beta	0.46	1.62
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.76	-1.17
PEG Ratio	-0.00	N/A
5Y EPS CAGR	N/A	-18.04%
Debt to Equity	0.00%	8.47%
Free Cash Flow Yield	-27.36%	-33.01%
P/S Ratio	4016.22	49.19
P/B Ratio	2.17	3.66

Market Cap

Winner

PMN

$130M

SPRB

$130M

Max Drawdown

Winner

PMN

99.69%

SPRB

99.81%

Sharpe Ratio

PMN

0.49

Winner

SPRB

0.97

5Y Beta

Winner

PMN

0.46

SPRB

1.62

Industry

PMN

Biotechnology

SPRB

Biotechnology

P/E Ratio

PMN

-0.76

Winner

SPRB

-1.17

PEG Ratio

PMN

-0.00

SPRB

N/A

5Y EPS CAGR

PMN

N/A

SPRB

-18.04%

Debt to Equity

Winner

PMN

0.00%

SPRB

8.47%

Free Cash Flow Yield

Winner

PMN

-27.36%

SPRB

-33.01%

P/S Ratio

PMN

4016.22

Winner

SPRB

49.19

P/B Ratio

Winner

PMN

2.17

SPRB

3.66

PMN vs SPRB - Historical Returns

Returns include dividend reinvestment.

Period	PMN	SPRB
1 month	-1.09%	+16.82%
3 months	+40.66%	+0.91%
6 months	-7.33%	+4.56%
1 year	+13.62%	+521.09%
5 years(CAGR)	-41.82%	-38.98%
10 years(CAGR)	-21.78%	N/A
Max(CAGR)	-22.70%	-42.07%

PMN

-1.09%

Winner

SPRB

+16.82%

Winner

PMN

+40.66%

SPRB

+0.91%

PMN

-7.33%

Winner

SPRB

+4.56%

PMN

+13.62%

Winner

SPRB

+521.09%

5Y(CAGR)

PMN

-41.82%

Winner

SPRB

-38.98%

10Y(CAGR)

PMN

-21.78%

SPRB

N/A

Max(CAGR)

Winner

PMN

-22.70%

SPRB

-42.07%

PMN vs SPRB - Annual Returns (2007 - 2026)

Returns include dividend reinvestment.

Year	PMN	SPRB
2026	+108.97%	-42.68%
2025	-71.56%	+176.94%
2024	-31.79%	-85.81%
2023	-74.44%	+154.78%
2022	-39.72%	-76.09%
2021	+37.50%	-80.40%
2020	-40.79%	+43.00%
2019	-38.36%	N/A
2018	+24.33%	N/A
2017	+41.67%	N/A
2016	+179.45%	N/A
2015	-74.83%	N/A
2014	-51.18%	N/A
2013	-15.78%	N/A
2012	+48.08%	N/A
2011	-37.20%	N/A
2010	-32.90%	N/A
2009	+20.40%	N/A
2008	-62.40%	N/A
2007	-10.70%	N/A

PMN vs SPRB Drawdown Comparison

The maximum drawdown for PMN was -99.69%, occurring on Nov 28, 2025. This drawdown has not yet recovered.

The maximum drawdown for SPRB was -99.81%, occurring on Jun 9, 2025. This drawdown has not yet recovered.

The current PMN drawdown is -99.31%. The current SPRB drawdown is -97.86%.

Rank	PMN	SPRB
#1	-99.69% Jul 31, 2007 - Nov 28, 2025	-99.81% Nov 27, 2020 - Jun 9, 2025
#2	-7.75% Jul 17, 2007 - Jul 20, 2007	-20.38% Oct 29, 2020 - Nov 13, 2020
#3	N/A	-13.84% Oct 14, 2020 - Oct 23, 2020
#4	N/A	-2.56% Nov 20, 2020 - Nov 27, 2020
#5	N/A	-2.16% Nov 16, 2020 - Nov 18, 2020