PIRS vs AYTU

Comparison between Pieris Pharmaceuticals Inc (PIRS, Company) and Aytu BioPharma Inc (AYTU, Company).

5-Year PerformancePIRS has outperformed AYTU, delivering a return of -44.7% compared to -54.0%

PIRS vs AYTU - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PIRS(COMPANY)	AYTU(COMPANY)
Market Cap	$24M	$24M
Max Drawdown	99.14%	100.00%
Sharpe Ratio	0.55	0.40
5Y Beta	N/A	0.00
Industry	N/A	Drug Manufacturers - Specialty & Generic
P/E Ratio	0.98	-0.64
Forward P/E	N/A	26.88
PEG Ratio	N/A	0.00
5Y EPS CAGR	N/A	-32.17%
Debt to Equity	0.00%	32.46%
Free Cash Flow Yield	62.31%	5.96%
P/S Ratio	1.47	0.42
P/B Ratio	1.48	0.70

Market Cap

Winner

PIRS

$24M

AYTU

$24M

Max Drawdown

Winner

PIRS

99.14%

AYTU

100.00%

Sharpe Ratio

Winner

PIRS

0.55

AYTU

0.40

5Y Beta

PIRS

N/A

AYTU

0.00

Industry

PIRS

N/A

AYTU

Drug Manufacturers - Specialty & Generic

P/E Ratio

PIRS

0.98

Winner

AYTU

-0.64

Forward P/E

PIRS

N/A

AYTU

26.88

PEG Ratio

PIRS

N/A

AYTU

0.00

5Y EPS CAGR

PIRS

N/A

AYTU

-32.17%

Debt to Equity

Winner

PIRS

0.00%

AYTU

32.46%

Free Cash Flow Yield

Winner

PIRS

62.31%

AYTU

5.96%

P/S Ratio

PIRS

1.47

Winner

AYTU

0.42

P/B Ratio

PIRS

1.48

Winner

AYTU

0.70

PIRS vs AYTU - Historical Returns

Returns include dividend reinvestment.

Period	PIRS	AYTU
1 month	-15.53%	-5.02%
3 months	-18.42%	-21.21%
6 months	+36.00%	-14.05%
1 year	+21.43%	+5.05%
5 years(CAGR)	-44.70%	-54.04%
10 years(CAGR)	-27.18%	-67.59%
Max(CAGR)	-27.18%	-67.59%

PIRS

-15.53%

Winner

AYTU

-5.02%

Winner

PIRS

-18.42%

AYTU

-21.21%

Winner

PIRS

+36.00%

AYTU

-14.05%

Winner

PIRS

+21.43%

AYTU

+5.05%

5Y(CAGR)

Winner

PIRS

-44.70%

AYTU

-54.04%

10Y(CAGR)

Winner

PIRS

-27.18%

AYTU

-67.59%

Max(CAGR)

Winner

PIRS

-27.18%

AYTU

-67.59%

PIRS vs AYTU - Annual Returns (2015 - 2026)

Returns include dividend reinvestment.

Year	PIRS	AYTU
2026	N/A	-24.91%
2025	N/A	+52.76%
2024	-8.70%	-41.18%
2023	-83.30%	-28.03%
2022	-73.40%	-87.81%
2021	+38.46%	-78.33%
2020	-26.90%	-42.50%
2019	+23.97%	+21.23%
2018	-65.68%	-98.28%
2017	+417.12%	-88.85%
2016	-38.64%	N/A
2015	-37.26%	N/A

PIRS vs AYTU Drawdown Comparison

The maximum drawdown for PIRS was -99.14%, occurring on Jul 11, 2024. This drawdown has not yet recovered.

The maximum drawdown for AYTU was -100.00%, occurring on Apr 7, 2025. This drawdown has not yet recovered.

The current PIRS drawdown is -98.20%. The current AYTU drawdown is -100.00%.

Rank	PIRS	AYTU
#1	-99.14% Feb 13, 2018 - Jul 11, 2024	-100.00% Feb 8, 2017 - Apr 7, 2025
#2	-67.74% Jun 23, 2015 - May 25, 2017	-11.00% Feb 1, 2017 - Feb 8, 2017
#3	-29.33% Apr 15, 2015 - Jun 19, 2015	N/A
#4	-28.33% Oct 5, 2017 - Dec 26, 2017	N/A
#5	-24.05% Jul 11, 2017 - Oct 2, 2017	N/A
#6	-14.31% Jun 2, 2017 - Jun 29, 2017	N/A
#7	-11.40% Feb 2, 2018 - Feb 9, 2018	N/A
#8	-10.71% Jan 2, 2018 - Jan 26, 2018	N/A
#9	-5.04% Jan 26, 2018 - Feb 2, 2018	N/A
#10	-4.11% Apr 13, 2015 - Apr 15, 2015	N/A
#11	-3.15% May 25, 2017 - May 30, 2017	N/A
#12	-1.50% Dec 26, 2017 - Dec 28, 2017	N/A
#13	-0.87% May 30, 2017 - Jun 1, 2017	N/A
#14	-0.32% Oct 2, 2017 - Oct 4, 2017	N/A