PBYI vs AVTX

Comparison between Puma Biotechnology Inc (PBYI, Company) and Avalo Therapeutics Inc (AVTX, Company).

Both PBYI and AVTX are from the Healthcare sector.

5-Year PerformancePBYI has outperformed AVTX, delivering a return of -4.3% compared to -71.8%

PBYI vs AVTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PBYI(COMPANY)	AVTX(COMPANY)
Market Cap	$404M	$404M
Max Drawdown	99.40%	99.98%
Sharpe Ratio	1.54	1.85
5Y Beta	0.79	0.54
Industry	Biotechnology	Biotechnology
P/E Ratio	16.37	-3.90
Forward P/E	3.46	N/A
Debt to Equity	8.79%	0.00%
Free Cash Flow Yield	13.23%	-12.74%
P/S Ratio	N/A	9875.25
P/B Ratio	N/A	3.78

Market Cap

Winner

PBYI

$404M

AVTX

$404M

Max Drawdown

Winner

PBYI

99.40%

AVTX

99.98%

Sharpe Ratio

PBYI

1.54

Winner

AVTX

1.85

5Y Beta

PBYI

0.79

Winner

AVTX

0.54

Industry

PBYI

Biotechnology

AVTX

Biotechnology

P/E Ratio

PBYI

16.37

Winner

AVTX

-3.90

Forward P/E

PBYI

3.46

AVTX

N/A

Debt to Equity

PBYI

8.79%

Winner

AVTX

0.00%

Free Cash Flow Yield

Winner

PBYI

13.23%

AVTX

-12.74%

P/S Ratio

PBYI

N/A

AVTX

9875.25

P/B Ratio

PBYI

N/A

AVTX

3.78

PBYI vs AVTX - Historical Returns

Returns include dividend reinvestment.

Period	PBYI	AVTX
1 month	+12.29%	+11.07%
3 months	+27.00%	+35.02%
6 months	+33.39%	-3.97%
1 year	+136.61%	+266.87%
5 years(CAGR)	-4.29%	-71.81%
10 years(CAGR)	-12.62%	-44.80%
Max(CAGR)	-3.92%	-45.56%

Winner

PBYI

+12.29%

AVTX

+11.07%

PBYI

+27.00%

Winner

AVTX

+35.02%

Winner

PBYI

+33.39%

AVTX

-3.97%

PBYI

+136.61%

Winner

AVTX

+266.87%

5Y(CAGR)

Winner

PBYI

-4.29%

AVTX

-71.81%

10Y(CAGR)

Winner

PBYI

-12.62%

AVTX

-44.80%

Max(CAGR)

Winner

PBYI

-3.92%

AVTX

-45.56%

PBYI vs AVTX - Annual Returns (2012 - 2026)

Returns include dividend reinvestment.

Year	PBYI	AVTX
2026	+37.78%	+6.70%
2025	+90.71%	+115.42%
2024	-32.60%	-14.70%
2023	+4.84%	-99.24%
2022	+32.60%	-76.80%
2021	-70.57%	-35.61%
2020	+21.71%	-47.51%
2019	-59.64%	+54.44%
2018	-78.04%	-3.00%
2017	+213.81%	+259.51%
2016	-58.25%	-77.13%
2015	-58.71%	-16.25%
2014	+85.45%	N/A
2013	+444.61%	N/A
2012	+33.93%	N/A

PBYI vs AVTX Drawdown Comparison

The maximum drawdown for PBYI was -99.40%, occurring on May 11, 2022. This drawdown has not yet recovered.

The maximum drawdown for AVTX was -99.98%, occurring on May 28, 2025. This drawdown has not yet recovered.

The current PBYI drawdown is -97.11%. The current AVTX drawdown is -99.91%.

Rank	PBYI	AVTX
#1	-99.40% Sep 18, 2014 - May 11, 2022	-99.98% Feb 27, 2019 - May 28, 2025
#2	-60.70% Jan 21, 2014 - Jul 23, 2014	-91.55% Nov 23, 2016 - Mar 7, 2018
#3	-39.73% Sep 9, 2013 - Dec 5, 2013	-60.57% Mar 17, 2016 - Nov 18, 2016
#4	-23.10% Jul 23, 2014 - Aug 18, 2014	-46.64% Mar 7, 2018 - Feb 25, 2019
#5	-21.43% Apr 24, 2012 - Aug 20, 2012	-35.56% Nov 16, 2015 - Mar 16, 2016
#6	-19.73% Oct 23, 2012 - Jan 15, 2013	N/A
#7	-19.28% Apr 17, 2013 - May 16, 2013	N/A
#8	-18.00% Jul 22, 2013 - Sep 9, 2013	N/A
#9	-15.23% Jan 24, 2013 - Mar 6, 2013	N/A
#10	-14.09% May 29, 2013 - Jun 19, 2013	N/A
#11	-10.14% Oct 8, 2012 - Oct 19, 2012	N/A
#12	-9.33% Aug 18, 2014 - Aug 26, 2014	N/A
#13	-8.78% Dec 9, 2013 - Dec 16, 2013	N/A
#14	-8.36% Mar 28, 2013 - Apr 15, 2013	N/A
#15	-7.30% Dec 24, 2013 - Jan 9, 2014	N/A