PBE vs MDST

Comparison between INVESCO BIOTECHNOLOGY & GENOME ETF (PBE, ETF) and Westwood Salient Enhanced Midstream Income ETF (MDST, ETF).

PBE is from the Healthcare sector, while MDST is from the Energy sector.

PBE vs MDST - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PBE(ETF)	MDST(ETF)
Net Assets	$247M	$247M
Expense Ratio	0.58%	0.80%
Max Drawdown	45.69%	16.16%
Sharpe Ratio	1.34	1.39
5Y Beta	0.76	0.46
P/E Ratio	34.32	23.98
Forward P/E	18.77	16.53
5Y Dividends CAGR	98.81%	N/A
5Y EPS CAGR	13.01%	15.65%
Debt to Equity	55.71%	N/A
P/S Ratio	4.97	1.13
P/B Ratio	4.45	3.44

Net Assets

Winner

PBE

$247M

MDST

$247M

Expense Ratio

Winner

PBE

0.58%

MDST

0.80%

Max Drawdown

PBE

45.69%

Winner

MDST

16.16%

Sharpe Ratio

PBE

1.34

Winner

MDST

1.39

5Y Beta

PBE

0.76

Winner

MDST

0.46

P/E Ratio

PBE

34.32

Winner

MDST

23.98

Forward P/E

PBE

18.77

Winner

MDST

16.53

5Y Dividends CAGR

PBE

98.81%

MDST

N/A

5Y EPS CAGR

PBE

13.01%

Winner

MDST

15.65%

Debt to Equity

PBE

55.71%

MDST

N/A

P/S Ratio

PBE

4.97

Winner

MDST

1.13

P/B Ratio

PBE

4.45

Winner

MDST

3.44

PBE vs MDST - Holdings Comparison

PBE and MDST have 1 common holdings. Overlap is -0.37%

PBE's top 25 holdings weight is 89.56%. MDST's top 25 holdings weight is 102.67%.

Rank	PBE	MDST
#1	UNITED THERAPEUTICS CORP (UTHR) - 6.14%	ENBRIDGE INC (n/a) - 9.10%
#2	ILLUMINA INC (ILMN) - 5.94%	ENERGY TRANSFER LP (ET) - 8.82%
#3	BIOGEN INC (BIIB) - 4.98%	WILLIAMS COMPANIES INC (WMB) - 8.76%
#4	INCYTE CORP (INCY) - 4.83%	ENTERPRISE PRODUCTS PARTNERS LP (EPD) - 6.95%
#5	GILEAD SCIENCES INC (GILD) - 4.55%	DT MIDSTREAM INC ORDINARY SHARES (DTM) - 6.49%
#6	ALNYLAM PHARMACEUTICALS INC (ALNY) - 4.46%	KINDER MORGAN INC CLASS P (KMI) - 5.74%
#7	AMGEN INC (AMGN) - 4.41%	SOUTH BOW CORP (n/a) - 5.43%
#8	REGENERON PHARMACEUTICALS INC (REGN) - 4.13%	TC ENERGY CORP (n/a) - 4.94%
#9	TG THERAPEUTICS INC (TGTX) - 3.57%	PEMBINA PIPELINE CORP (n/a) - 4.90%
#10	CATALYST PHARMACEUTICALS INC (CPRX) - 3.55%	ONEOK INC (OKE) - 4.83%
#11	VERACYTE INC (VCYT) - 3.40%	TARGA RESOURCES CORP (TRGP) - 4.67%
#12	ARROWHEAD PHARMACEUTICALS INC (ARWR) - 3.39%	PLAINS GP HOLDINGS LP CLASS A (PAGP) - 4.59%
#13	NEUROCRINE BIOSCIENCES INC (NBIX) - 3.26%	ANTERO MIDSTREAM CORP (AM) - 4.44%
#14	ROYALTY PHARMA PLC CLASS A (RPRX) - 3.25%	MPLX LP PARTNERSHIP UNITS (MPLX) - 4.38%
#15	PROTAGONIST THERAPEUTICS INC (PTGX) - 3.14%	CHENIERE ENERGY INC (LNG) - 4.37%
#16	CAREDX INC (CDNA) - 3.07%	HESS MIDSTREAM LP CLASS A (HESM) - 4.19%
#17	BIOCRYST PHARMACEUTICALS INC (BCRX) - 3.05%	KINETIK HOLDINGS INC (KNTK) - 3.08%
#18	EXELIXIS INC (EXEL) - 3.04%	WESTERN MIDSTREAM PARTNERS LP (WES) - 2.49%
#19	PTC THERAPEUTICS INC (PTCT) - 2.69%	n/a (VG) - 1.49%
#20	HALOZYME THERAPEUTICS INC (HALO) - 2.68%	US DOLLARS (n/a) - 1.12%
#21	VERICEL CORP (VCEL) - 2.51%	NEXTDECADE CORP (NEXT) - 0.92%
#22	IONIS PHARMACEUTICALS INC (IONS) - 2.44%	DELEK LOGISTICS PARTNERS LP (DKL) - 0.44%
#23	ACADIA PHARMACEUTICALS INC (ACAD) - 2.37%	SELECT WATER SOLUTIONS INC CLASS A (WTTR) - 0.39%
#24	THERAVANCE BIOPHARMA INC (TBPH) - 2.36%	GENESIS ENERGY LP (GEL) - 0.14%
#25	REPLIGEN CORP (RGEN) - 2.35%	KMI US 06/18/26 C33 (n/a) - 0.00%
Total Holdings	33	108

PBE vs MDST - Historical Returns

Returns include dividend reinvestment.

Period	PBE	MDST
1 month	+3.45%	+1.81%
3 months	+6.06%	+5.42%
6 months	+2.77%	+16.47%
1 year	+31.27%	+21.20%
5 years(CAGR)	+3.29%	N/A
10 years(CAGR)	+7.50%	N/A
Max(CAGR)	+8.87%	+19.78%

Winner

PBE

+3.45%

MDST

+1.81%

Winner

PBE

+6.06%

MDST

+5.42%

PBE

+2.77%

Winner

MDST

+16.47%

Winner

PBE

+31.27%

MDST

+21.20%

5Y(CAGR)

PBE

+3.29%

MDST

N/A

10Y(CAGR)

PBE

+7.50%

MDST

N/A

Max(CAGR)

PBE

+8.87%

Winner

MDST

+19.78%

PBE vs MDST - Annual Returns (2005 - 2026)

Returns include dividend reinvestment.

Year	PBE	MDST
2026	+1.48%	+16.38%
2025	+23.76%	+5.61%
2024	-0.05%	+17.22%
2023	+4.60%	N/A
2022	-11.11%	N/A
2021	+1.21%	N/A
2020	+25.68%	N/A
2019	+18.35%	N/A
2018	-2.62%	N/A
2017	+20.54%	N/A
2016	-20.66%	N/A
2015	+1.36%	N/A
2014	+36.45%	N/A
2013	+57.53%	N/A
2012	+13.17%	N/A
2011	-7.24%	N/A
2010	+29.99%	N/A
2009	+19.16%	N/A
2008	-25.84%	N/A
2007	+6.24%	N/A
2006	+0.45%	N/A
2005	+17.45%	N/A

PBE vs MDST Drawdown Comparison

The maximum drawdown for PBE was -45.69%, occurring on Mar 9, 2009. Recovery took 644 trading sessions.

The maximum drawdown for MDST was -14.19%, occurring on Apr 8, 2025. Recovery took 82 trading sessions.

The current PBE drawdown is -2.53%. The current MDST drawdown is -1.35%.

Rank	PBE	MDST
#1	-45.69% Oct 15, 2007 - May 6, 2010	-14.19% Apr 2, 2025 - Jul 31, 2025
#2	-44.56% Jul 17, 2015 - Jul 20, 2020	-7.50% Jan 21, 2025 - Apr 2, 2025
#3	-37.84% Feb 8, 2021 - Nov 26, 2025	-7.20% Nov 29, 2024 - Jan 14, 2025
#4	-35.71% May 6, 2010 - Apr 2, 2013	-6.75% Jul 31, 2025 - Dec 4, 2025
#5	-21.12% Feb 27, 2006 - Apr 23, 2007	-4.99% May 19, 2026 - May 29, 2026
#6	-18.86% Feb 24, 2014 - Aug 25, 2014	-4.30% Mar 27, 2026 - Apr 30, 2026
#7	-14.38% Jul 20, 2020 - Nov 27, 2020	-4.21% Jul 22, 2024 - Aug 19, 2024
#8	-11.73% Jan 7, 2026 - Mar 27, 2026	-3.67% Apr 9, 2024 - Apr 25, 2024
#9	-10.65% Mar 19, 2015 - Jun 18, 2015	-3.16% May 4, 2026 - May 13, 2026
#10	-10.08% Sep 12, 2005 - Nov 17, 2005	-3.11% Dec 4, 2025 - Jan 2, 2026
#11	-9.07% Apr 25, 2007 - Sep 26, 2007	-3.01% May 20, 2024 - Jun 24, 2024
#12	-8.60% Aug 29, 2014 - Oct 23, 2014	-2.73% Jan 2, 2026 - Jan 16, 2026
#13	-7.84% May 28, 2013 - Jul 5, 2013	-2.67% Sep 23, 2024 - Oct 3, 2024
#14	-7.21% Nov 29, 2013 - Jan 7, 2014	-2.35% Aug 30, 2024 - Sep 16, 2024
#15	-6.59% Oct 2, 2013 - Oct 24, 2013	-2.30% Apr 25, 2024 - May 7, 2024

Correlation

Correlation between PBE and MDST is 0.73 which considered as a strong positive correlation - the stocks tend to move together.

0.73

-101

Dividend Comparison (2009 - 2026)

PBE vs MDST dividend yield comparison.

Year	PBE	MDST
2026	0.10%	4.56%
2025	1.00%	10.22%
2024	0.05%	6.60%
2023	0.02%	0.00%
2020	0.04%	0.00%
2018	0.00%	0.00%
2017	0.57%	0.00%
2016	0.38%	0.00%
2015	1.12%	0.00%
2014	0.55%	0.00%
2009	0.45%	0.00%