OBIO vs ACIU

Comparison between Orchestra BioMed Holdings Inc (OBIO, Company) and AC Immune SA (ACIU, Company).

Both OBIO and ACIU are from the Healthcare sector.

5-Year PerformanceOBIO has outperformed ACIU, delivering a return of -16.7% compared to -21.3%

OBIO vs ACIU - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	OBIO(COMPANY)	ACIU(COMPANY)
Market Cap	$223M	$224M
Max Drawdown	89.40%	92.33%
Sharpe Ratio	0.64	0.33
5Y Beta	1.66	1.03
Industry	Biotechnology	Biotechnology
P/E Ratio	-3.41	-2.72
Forward P/E	N/A	11.24
PEG Ratio	N/A	-0.06
5Y EPS CAGR	N/A	-4.76%
Debt to Equity	36.41%	13.65%
Free Cash Flow Yield	-24.72%	-28.64%
P/S Ratio	6.95	62.41
P/B Ratio	5.60	6.10

Market Cap

OBIO

$223M

Winner

ACIU

$224M

Max Drawdown

Winner

OBIO

89.40%

ACIU

92.33%

Sharpe Ratio

Winner

OBIO

0.64

ACIU

0.33

5Y Beta

OBIO

1.66

Winner

ACIU

1.03

Industry

OBIO

Biotechnology

ACIU

Biotechnology

P/E Ratio

Winner

OBIO

-3.41

ACIU

-2.72

Forward P/E

OBIO

N/A

ACIU

11.24

PEG Ratio

OBIO

N/A

ACIU

-0.06

5Y EPS CAGR

OBIO

N/A

ACIU

-4.76%

Debt to Equity

OBIO

36.41%

Winner

ACIU

13.65%

Free Cash Flow Yield

Winner

OBIO

-24.72%

ACIU

-28.64%

P/S Ratio

Winner

OBIO

6.95

ACIU

62.41

P/B Ratio

Winner

OBIO

5.60

ACIU

6.10

OBIO vs ACIU - Historical Returns

Returns include dividend reinvestment.

Period	OBIO	ACIU
1 month	-7.44%	-7.98%
3 months	+0.25%	-26.51%
6 months	+14.04%	-31.35%
1 year	+30.07%	+1.39%
5 years(CAGR)	-16.67%	-21.35%
10 years(CAGR)	N/A	-18.10%
Max(CAGR)	-16.12%	-18.10%

Winner

OBIO

-7.44%

ACIU

-7.98%

Winner

OBIO

+0.25%

ACIU

-26.51%

Winner

OBIO

+14.04%

ACIU

-31.35%

Winner

OBIO

+30.07%

ACIU

+1.39%

5Y(CAGR)

Winner

OBIO

-16.67%

ACIU

-21.35%

10Y(CAGR)

OBIO

N/A

ACIU

-18.10%

Max(CAGR)

Winner

OBIO

-16.12%

ACIU

-18.10%

OBIO vs ACIU - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	OBIO	ACIU
2026	-7.66%	-34.82%
2025	-22.86%	+10.18%
2024	-54.44%	-42.43%
2023	-9.06%	+126.24%
2022	+0.71%	-60.47%
2021	-22.46%	-6.95%
2020	+12.37%	-40.30%
2019	N/A	-16.63%
2018	N/A	-29.21%
2017	N/A	-1.61%
2016	N/A	-17.11%

OBIO vs ACIU Drawdown Comparison

The maximum drawdown for OBIO was -89.40%, occurring on Sep 23, 2025. This drawdown has not yet recovered.

The maximum drawdown for ACIU was -92.33%, occurring on Apr 10, 2025. This drawdown has not yet recovered.

The current OBIO drawdown is -82.06%. The current ACIU drawdown is -88.65%.

Rank	OBIO	ACIU
#1	-89.40% Apr 12, 2023 - Sep 23, 2025	-92.33% Sep 28, 2016 - Apr 10, 2025
#2	-42.60% Feb 16, 2021 - Mar 6, 2023	N/A
#3	-33.00% Mar 6, 2023 - Mar 31, 2023	N/A
#4	-14.37% Aug 6, 2020 - Dec 30, 2020	N/A
#5	-13.31% Dec 30, 2020 - Feb 8, 2021	N/A
#6	-5.52% Mar 31, 2023 - Apr 5, 2023	N/A
#7	-1.63% Apr 5, 2023 - Apr 11, 2023	N/A
#8	-0.53% Feb 8, 2021 - Feb 10, 2021	N/A