KPTI vs LVTX

Comparison between Karyopharm Therapeutics Inc (KPTI, Company) and LAVA Therapeutics NV (LVTX, Company).

Both KPTI and LVTX are from the Healthcare sector.

5-Year PerformanceLVTX has outperformed KPTI, delivering a return of -36.1% compared to -51.0%

KPTI vs LVTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	KPTI(COMPANY)	LVTX(COMPANY)
Market Cap	$46M	$46M
Max Drawdown	99.74%	94.34%
Sharpe Ratio	-0.25	0.31
5Y Beta	0.75	N/A
Industry	Biotechnology	Biotechnology
P/E Ratio	-0.14	-1.97
PEG Ratio	-0.00	N/A
5Y EPS CAGR	-18.43%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	N/A	-67.20%
P/S Ratio	0.30	N/A
P/B Ratio	12.05	N/A

Market Cap

KPTI

$46M

Winner

LVTX

$46M

Max Drawdown

KPTI

99.74%

Winner

LVTX

94.34%

Sharpe Ratio

KPTI

-0.25

Winner

LVTX

0.31

5Y Beta

KPTI

0.75

LVTX

N/A

Industry

KPTI

Biotechnology

LVTX

Biotechnology

P/E Ratio

KPTI

-0.14

Winner

LVTX

-1.97

PEG Ratio

KPTI

-0.00

LVTX

N/A

5Y EPS CAGR

KPTI

-18.43%

LVTX

N/A

Debt to Equity

KPTI

0.00%

LVTX

0.00%

Free Cash Flow Yield

KPTI

N/A

LVTX

-67.20%

P/S Ratio

KPTI

0.30

LVTX

N/A

P/B Ratio

KPTI

12.05

LVTX

N/A

KPTI vs LVTX - Historical Returns

Returns include dividend reinvestment.

Period	KPTI	LVTX
1 month	-75.08%	+7.74%
3 months	-75.68%	+10.83%
6 months	-79.73%	+33.85%
1 year	-67.44%	+3.57%
5 years(CAGR)	-50.99%	-36.13%
10 years(CAGR)	-33.54%	N/A
Max(CAGR)	-31.35%	-36.13%

KPTI

-75.08%

Winner

LVTX

+7.74%

KPTI

-75.68%

Winner

LVTX

+10.83%

KPTI

-79.73%

Winner

LVTX

+33.85%

KPTI

-67.44%

Winner

LVTX

+3.57%

5Y(CAGR)

KPTI

-50.99%

Winner

LVTX

-36.13%

10Y(CAGR)

KPTI

-33.54%

LVTX

N/A

Max(CAGR)

Winner

KPTI

-31.35%

LVTX

-36.13%

KPTI vs LVTX - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	KPTI	LVTX
2026	-72.74%	N/A
2025	-39.54%	+68.93%
2024	-24.96%	-45.75%
2023	-73.47%	-56.11%
2022	-52.11%	-41.76%
2021	-62.00%	-61.54%
2020	-17.31%	N/A
2019	+100.52%	N/A
2018	-5.54%	N/A
2017	-0.41%	N/A
2016	-30.16%	N/A
2015	-65.12%	N/A
2014	+62.67%	N/A
2013	+42.80%	N/A

KPTI vs LVTX Drawdown Comparison

The maximum drawdown for KPTI was -99.74%, occurring on Aug 17, 2026. This drawdown has not yet recovered.

The maximum drawdown for LVTX was -94.34%, occurring on Feb 11, 2025. This drawdown has not yet recovered.

The current KPTI drawdown is -99.72%. The current LVTX drawdown is -89.13%.

Rank	KPTI	LVTX
#1	-99.74% Jun 13, 2014 - Aug 17, 2026	-94.34% Apr 13, 2021 - Feb 11, 2025
#2	-43.74% Mar 6, 2014 - Jun 13, 2014	-14.42% Mar 31, 2021 - Apr 6, 2021
#3	-10.42% Dec 20, 2013 - Jan 15, 2014	-12.59% Mar 25, 2021 - Mar 31, 2021
#4	-9.08% Jan 31, 2014 - Feb 12, 2014	-4.89% Apr 6, 2021 - Apr 13, 2021
#5	-8.83% Mar 4, 2014 - Mar 6, 2014	N/A
#6	-5.88% Jan 22, 2014 - Jan 30, 2014	N/A
#7	-4.87% Feb 27, 2014 - Mar 4, 2014	N/A
#8	-4.36% Feb 13, 2014 - Feb 20, 2014	N/A
#9	-3.39% Dec 9, 2013 - Dec 13, 2013	N/A
#10	-1.60% Nov 29, 2013 - Dec 6, 2013	N/A
#11	-1.48% Nov 8, 2013 - Nov 29, 2013	N/A
#12	-0.44% Nov 6, 2013 - Nov 8, 2013	N/A