ISCB vs PBE
Comparison between ISHARES MORNINGSTAR SMALL-CAP ETF (ISCB, ETF) and INVESCO BIOTECHNOLOGY & GENOME ETF (PBE, ETF).
5-Year PerformanceISCB has outperformed PBE, delivering a return of +7.5% compared to +5.4%
ISCB vs PBE - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Net Assets
Winner
ISCB
$282M
PBE
$282M
Expense Ratio
Winner
ISCB
0.04%
PBE
0.58%
Max Drawdown
ISCB
61.85%
Winner
PBE
45.69%
Sharpe Ratio
ISCB
1.16
Winner
PBE
1.90
5Y Beta
ISCB
1.03
Winner
PBE
0.72
P/E Ratio
ISCB
47.22
Winner
PBE
35.79
Forward P/E
Winner
ISCB
16.89
PBE
21.17
5Y Dividends CAGR
ISCB
9.58%
PBE
N/A
5Y EPS CAGR
Winner
ISCB
6.15%
PBE
3.37%
Debt to Equity
ISCB
151.94%
Winner
PBE
93.58%
P/S Ratio
Winner
ISCB
1.51
PBE
4.77
P/B Ratio
Winner
ISCB
2.46
PBE
4.58
ISCB vs PBE - Holdings Comparison
ISCB and PBE have 17 common holdings. Overlap is 1.41%
ISCB's top 25 holdings weight is 6.68%. PBE's top 25 holdings weight is 90.34%.
| Rank | ISCB | PBE |
|---|---|---|
| #1 | OKTA INC CLASS A (OKTA) - 0.38% | REGENERON PHARMACEUTICALS INC (REGN) - 5.46% |
| #2 | BLACKROCK CASH FUNDS TREASURY SL AGENCY (n/a) - 0.38% | AMGEN INC (AMGN) - 5.41% |
| #3 | ATLASSIAN CORP CLASS A (TEAM) - 0.37% | VERTEX PHARMACEUTICALS INC (VRTX) - 5.19% |
| #4 | GUARDANT HEALTH INC (GH) - 0.32% | CAREDX INC (CDNA) - 5.00% |
| #5 | ROKU INC CLASS A (ROKU) - 0.30% | ROYALTY PHARMA PLC CLASS A (RPRX) - 4.74% |
| #6 | n/a (ZBRA) - 0.28% | BIOGEN INC (BIIB) - 4.71% |
| #7 | AKAMAI TECHNOLOGIES INC (AKAM) - 0.27% | GILEAD SCIENCES INC (GILD) - 4.59% |
| #8 | NUTANIX INC CLASS A (NTNX) - 0.26% | UNITED THERAPEUTICS CORP (UTHR) - 3.83% |
| #9 | JONES LANG LASALLE INC (JLL) - 0.26% | PROTAGONIST THERAPEUTICS INC (PTGX) - 3.67% |
| #10 | STERLING INFRASTRUCTURE INC (STRL) - 0.26% | HALOZYME THERAPEUTICS INC (HALO) - 3.56% |
| #11 | ONTO INNOVATION INC (ONTO) - 0.26% | BIO-TECHNE CORP (TECH) - 3.51% |
| #12 | BEST BUY CO INC (BBY) - 0.25% | OMEROS CORP (OMER) - 3.44% |
| #13 | IDEX CORP (IEX) - 0.25% | REPLIGEN CORP (RGEN) - 3.37% |
| #14 | STANLEY BLACK & DECKER INC (SWK) - 0.24% | ACADIA PHARMACEUTICALS INC (ACAD) - 3.31% |
| #15 | LINCOLN ELECTRIC HOLDINGS INC (LECO) - 0.24% | ALNYLAM PHARMACEUTICALS INC (ALNY) - 3.31% |
| #16 | ESCO TECHNOLOGIES INC (ESE) - 0.24% | ILLUMINA INC (ILMN) - 3.02% |
| #17 | GEN DIGITAL INC (GEN) - 0.24% | INCYTE CORP (INCY) - 2.97% |
| #18 | NEUROCRINE BIOSCIENCES INC (NBIX) - 0.24% | BIOMARIN PHARMACEUTICAL INC (BMRN) - 2.96% |
| #19 | PINNACLE FINANCIAL PARTNERS INC (PNFP) - 0.24% | VERICEL CORP (VCEL) - 2.95% |
| #20 | ARAMARK (ARMK) - 0.24% | QIAGEN NV (QGEN) - 2.78% |
| #21 | FEDERAL SIGNAL CORP (FSS) - 0.24% | BIOCRYST PHARMACEUTICALS INC (BCRX) - 2.67% |
| #22 | ARMSTRONG WORLD INDUSTRIES INC (AWI) - 0.24% | SAREPTA THERAPEUTICS INC (SRPT) - 2.52% |
| #23 | NORDSON CORP (NDSN) - 0.24% | PTC THERAPEUTICS INC (PTCT) - 2.51% |
| #24 | ENPRO INC (NPO) - 0.22% | EXELIXIS INC (EXEL) - 2.48% |
| #25 | FIRST INDUSTRIAL REALTY TRUST INC (FR) - 0.22% | ANAPTYSBIO INC (ANAB) - 2.38% |
| Total Holdings | 1481 | 33 |
ISCB vs PBE - Historical Returns
Returns include dividend reinvestment.
1M
ISCB
+3.05%
Winner
PBE
+10.20%
3M
ISCB
+5.47%
Winner
PBE
+21.09%
6M
ISCB
+10.49%
Winner
PBE
+22.29%
1Y
ISCB
+24.07%
Winner
PBE
+48.89%
5Y(CAGR)
Winner
ISCB
+7.45%
PBE
+5.37%
10Y(CAGR)
Winner
ISCB
+11.44%
PBE
+9.63%
Max(CAGR)
Winner
ISCB
+11.96%
PBE
+9.68%
ISCB vs PBE - Annual Returns (2004 - 2026)
Returns include dividend reinvestment.
| Year | ISCB | PBE |
|---|---|---|
| 2026 | +16.65% | +21.18% |
| 2025 | +12.40% | +23.76% |
| 2024 | +11.73% | -0.05% |
| 2023 | +20.10% | +4.60% |
| 2022 | -19.85% | -11.11% |
| 2021 | +20.22% | +1.21% |
| 2020 | +11.73% | +25.68% |
| 2019 | +34.37% | +18.35% |
| 2018 | -10.71% | -2.62% |
| 2017 | +17.23% | +20.54% |
| 2016 | +32.34% | -20.66% |
| 2015 | -1.64% | +1.36% |
| 2014 | +14.26% | +36.45% |
| 2013 | +37.06% | +57.53% |
| 2012 | +20.92% | +13.17% |
| 2011 | -3.49% | -7.24% |
| 2010 | +29.09% | +29.99% |
| 2009 | +41.02% | +19.16% |
| 2008 | -33.32% | -25.84% |
| 2007 | -2.62% | +6.24% |
| 2006 | +21.67% | +0.45% |
| 2005 | +10.53% | +17.45% |
| 2004 | +16.19% | N/A |
ISCB vs PBE Drawdown Comparison
The maximum drawdown for ISCB was -59.60%, occurring on Mar 9, 2009. Recovery took 853 trading sessions.
The maximum drawdown for PBE was -45.69%, occurring on Mar 9, 2009. Recovery took 644 trading sessions.
The current ISCB drawdown is -1.86%.
| Rank | ISCB | PBE |
|---|---|---|
| #1 | -59.60% Jul 13, 2007 - Dec 1, 2010 | -45.69% Oct 15, 2007 - May 6, 2010 |
| #2 | -44.18% Jan 16, 2020 - Nov 16, 2020 | -44.56% Jul 17, 2015 - Jul 20, 2020 |
| #3 | -29.93% Nov 8, 2021 - Oct 14, 2024 | -37.84% Feb 8, 2021 - Nov 26, 2025 |
| #4 | -29.52% Jul 7, 2011 - Sep 6, 2012 | -35.71% May 6, 2010 - Apr 2, 2013 |
| #5 | -26.22% Nov 25, 2024 - Sep 11, 2025 | -21.12% Feb 27, 2006 - Apr 23, 2007 |
| #6 | -22.48% Aug 31, 2018 - Jul 3, 2019 | -18.86% Feb 24, 2014 - Aug 25, 2014 |
| #7 | -19.72% Jun 24, 2015 - Jun 23, 2016 | -14.38% Jul 20, 2020 - Nov 27, 2020 |
| #8 | -13.40% May 5, 2006 - Oct 16, 2006 | -11.73% Jan 7, 2026 - Jun 23, 2026 |
| #9 | -11.23% Jul 1, 2014 - Nov 24, 2014 | -10.65% Mar 19, 2015 - Jun 18, 2015 |
| #10 | -10.53% Mar 4, 2005 - Jun 16, 2005 | -10.08% Sep 12, 2005 - Nov 17, 2005 |
| #11 | -9.74% Apr 29, 2011 - Jul 7, 2011 | -9.07% Apr 25, 2007 - Sep 26, 2007 |
| #12 | -9.58% Jun 8, 2021 - Nov 1, 2021 | -8.60% Aug 29, 2014 - Oct 23, 2014 |
| #13 | -9.40% Feb 10, 2026 - Apr 17, 2026 | -7.84% May 28, 2013 - Jul 5, 2013 |
| #14 | -9.00% Jul 2, 2004 - Sep 13, 2004 | -7.21% Nov 29, 2013 - Jan 7, 2014 |
| #15 | -8.54% Jan 23, 2018 - May 21, 2018 | -6.59% Oct 2, 2013 - Oct 24, 2013 |
Correlation
Correlation between ISCB and PBE is 0.96 which considered as a very strong positive correlation - the stocks move almost identically together.
0.96
-101
Dividend Comparison (2004 - 2026)
ISCB vs PBE dividend yield comparison.
| Year | ISCB | PBE |
|---|---|---|
| 2026 | 0.53% | 0.90% |
| 2025 | 1.38% | 1.00% |
| 2024 | 1.31% | 0.05% |
| 2023 | 1.49% | 0.02% |
| 2022 | 1.63% | 0.00% |
| 2021 | 2.03% | 0.00% |
| 2020 | 5.06% | 0.04% |
| 2019 | 5.01% | 0.00% |
| 2018 | 6.39% | 0.00% |
| 2017 | 4.95% | 0.57% |
| 2016 | 6.33% | 0.38% |
| 2015 | 5.59% | 1.12% |
| 2014 | 4.71% | 0.55% |
| 2013 | 3.46% | 0.00% |
| 2012 | 7.43% | 0.00% |
| 2011 | 4.05% | 0.00% |
| 2010 | 4.14% | 0.00% |
| 2009 | 3.55% | 0.45% |
| 2008 | 4.09% | 0.00% |
| 2007 | 4.04% | 0.00% |
| 2006 | 2.91% | 0.00% |
| 2005 | 3.15% | 0.00% |
| 2004 | 1.80% | 0.00% |
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