IBB vs SPYI

Comparison between ISHARES BIOTECHNOLOGY ETF (IBB, ETF) and NEOS S&P 500(R) HIGH INCOME ETF (SPYI, ETF).

IBB vs SPYI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IBB(ETF)	SPYI(ETF)
Net Assets	$8.10B	$8.10B
Expense Ratio	0.44%	0.68%
Max Drawdown	62.85%	18.53%
Sharpe Ratio	1.66	2.04
5Y Beta	0.80	0.82
P/E Ratio	-240.05	28.49
Forward P/E	17.67	21.87
5Y Dividends CAGR	10.38%	N/A
5Y EPS CAGR	24.54%	28.89%
Debt to Equity	99.91%	33.01%
P/S Ratio	7.06	3.51
P/B Ratio	4.64	5.41

Net Assets

IBB

$8.10B

SPYI

$8.10B

Expense Ratio

Winner

IBB

0.44%

SPYI

0.68%

Max Drawdown

IBB

62.85%

Winner

SPYI

18.53%

Sharpe Ratio

IBB

1.66

Winner

SPYI

2.04

5Y Beta

Winner

IBB

0.80

SPYI

0.82

P/E Ratio

Winner

IBB

-240.05

SPYI

28.49

Forward P/E

Winner

IBB

17.67

SPYI

21.87

5Y Dividends CAGR

IBB

10.38%

SPYI

N/A

5Y EPS CAGR

IBB

24.54%

Winner

SPYI

28.89%

Debt to Equity

IBB

99.91%

Winner

SPYI

33.01%

P/S Ratio

IBB

7.06

Winner

SPYI

3.51

P/B Ratio

Winner

IBB

4.64

SPYI

5.41

IBB vs SPYI - Holdings Comparison

IBB and SPYI have 9 common holdings. Overlap is -3.29%

IBB's top 25 holdings weight is 68.66%. SPYI's top 25 holdings weight is 51.07%.

Rank	IBB	SPYI
#1	GILEAD SCIENCES INC (GILD) - 9.71%	NVIDIA CORP (NVDA) - 8.63%
#2	VERTEX PHARMACEUTICALS INC (VRTX) - 9.05%	APPLE INC (AAPL) - 6.74%
#3	AMGEN INC (AMGN) - 8.92%	MICROSOFT CORP (MSFT) - 5.32%
#4	REGENERON PHARMACEUTICALS INC (REGN) - 6.89%	AMAZON.COM INC (AMZN) - 4.23%
#5	ALNYLAM PHARMACEUTICALS INC (ALNY) - 3.72%	ALPHABET INC CLASS A (GOOGL) - 3.39%
#6	INSMED INC (INSM) - 2.73%	BROADCOM INC (AVGO) - 3.15%
#7	ARGENX SE ADR (ARGX) - 2.56%	ALPHABET INC CLASS C (GOOG) - 2.70%
#8	BIOGEN INC (BIIB) - 2.41%	META PLATFORMS INC CLASS A (META) - 2.51%
#9	NATERA INC (NTRA) - 2.33%	TESLA INC (TSLA) - 1.76%
#10	UNITED THERAPEUTICS CORP (UTHR) - 2.00%	BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.48%
#11	BEONE MEDICINES LTD ADR (ONC) - 1.88%	JPMORGAN CHASE & CO (JPM) - 1.39%
#12	MODERNA INC (MRNA) - 1.66%	ELI LILLY AND CO (LLY) - 1.18%
#13	INCYTE CORP (INCY) - 1.62%	EXXON MOBIL CORP (XOM) - 1.04%
#14	ILLUMINA INC (ILMN) - 1.59%	MICRON TECHNOLOGY INC (MU) - 0.94%
#15	REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 1.47%	WALMART INC (WMT) - 0.94%
#16	GENMAB AS ADR (GMAB) - 1.17%	JOHNSON & JOHNSON (JNJ) - 0.92%
#17	NEUROCRINE BIOSCIENCES INC (NBIX) - 1.13%	ADVANCED MICRO DEVICES INC (AMD) - 0.89%
#18	ROIVANT SCIENCES LTD ORDINARY SHARES (ROIV) - 1.10%	VISA INC CLASS A (V) - 0.88%
#19	BRIDGEBIO PHARMA INC (BBIO) - 1.05%	CASH OFFSET (n/a) - 0.81%
#20	IONIS PHARMACEUTICALS INC (IONS) - 1.03%	COSTCO WHOLESALE CORP (COST) - 0.74%
#21	BIOMARIN PHARMACEUTICAL INC (BMRN) - 0.98%	AMPHENOL CORP CLASS A (APH) - 0.29%
#22	ASCENDIS PHARMA AS ADR (ASND) - 0.96%	ARISTA NETWORKS INC (ANET) - 0.29%
#23	EXELIXIS INC (EXEL) - 0.96%	TJX COMPANIES INC (TJX) - 0.29%
#24	MEDPACE HOLDINGS INC (MEDP) - 0.92%	INTUITIVE SURGICAL INC (ISRG) - 0.28%
#25	MADRIGAL PHARMACEUTICALS INC (MDGL) - 0.82%	AMERICAN EXPRESS CO (AXP) - 0.28%
Total Holdings	258	471

IBB vs SPYI - Historical Returns

Returns include dividend reinvestment.

Period	IBB	SPYI
1 month	-1.12%	+6.05%
3 months	-2.47%	+4.00%
6 months	+7.94%	+8.73%
1 year	+42.93%	+25.62%
5 years(CAGR)	+2.84%	N/A
10 years(CAGR)	+7.17%	N/A
Max(CAGR)	+6.71%	+15.37%

IBB

-1.12%

Winner

SPYI

+6.05%

IBB

-2.47%

Winner

SPYI

+4.00%

IBB

+7.94%

Winner

SPYI

+8.73%

Winner

IBB

+42.93%

SPYI

+25.62%

5Y(CAGR)

IBB

+2.84%

SPYI

N/A

10Y(CAGR)

IBB

+7.17%

SPYI

N/A

Max(CAGR)

IBB

+6.71%

Winner

SPYI

+15.37%

IBB vs SPYI - Annual Returns (2001 - 2026)

Returns include dividend reinvestment.

Year	IBB	SPYI
2026	+0.63%	+5.73%
2025	+27.31%	+16.80%
2024	-3.98%	+19.49%
2023	+4.76%	+18.18%
2022	-13.55%	-2.44%
2021	+1.62%	N/A
2020	+26.66%	N/A
2019	+24.04%	N/A
2018	-11.66%	N/A
2017	+18.90%	N/A
2016	-18.66%	N/A
2015	+10.47%	N/A
2014	+33.81%	N/A
2013	+60.40%	N/A
2012	+30.91%	N/A
2011	+10.68%	N/A
2010	+13.15%	N/A
2009	+13.54%	N/A
2008	-11.83%	N/A
2007	+4.68%	N/A
2006	-0.82%	N/A
2005	+3.75%	N/A
2004	+3.40%	N/A
2003	+41.11%	N/A
2002	-44.49%	N/A
2001	-12.03%	N/A

IBB vs SPYI Drawdown Comparison

The maximum drawdown for IBB was -62.85%, occurring on Jul 10, 2002. Recovery took 2488 trading sessions.

The maximum drawdown for SPYI was -16.46%, occurring on Apr 8, 2025. Recovery took 87 trading sessions.

The current IBB drawdown is -4.26%.

Rank	IBB	SPYI
#1	-62.85% Jun 5, 2001 - Apr 27, 2011	-16.46% Feb 19, 2025 - Jun 25, 2025
#2	-39.82% Aug 9, 2021 - Jan 7, 2026	-10.18% Sep 12, 2022 - Feb 1, 2023
#3	-39.24% Jul 20, 2015 - May 11, 2020	-7.70% Feb 25, 2026 - Apr 15, 2026
#4	-34.69% Feb 12, 2001 - May 22, 2001	-7.54% Jul 28, 2023 - Dec 13, 2023
#5	-22.65% Jul 8, 2011 - Jan 10, 2012	-6.60% Jul 16, 2024 - Aug 19, 2024
#6	-21.18% Feb 25, 2014 - Aug 26, 2014	-6.03% Feb 6, 2023 - Apr 13, 2023
#7	-15.26% Feb 8, 2021 - Aug 5, 2021	-4.65% Mar 28, 2024 - May 15, 2024
#8	-12.98% Jul 20, 2020 - Dec 3, 2020	-3.96% Nov 12, 2025 - Nov 28, 2025
#9	-12.75% Oct 5, 2012 - Feb 1, 2013	-3.50% Aug 30, 2024 - Sep 19, 2024
#10	-9.81% May 14, 2013 - Jul 11, 2013	-3.11% Dec 6, 2024 - Jan 22, 2025
#11	-9.63% Jan 22, 2026 - Mar 27, 2026	-2.32% Oct 8, 2025 - Oct 20, 2025
#12	-9.25% Apr 23, 2015 - Jun 11, 2015	-2.15% Feb 2, 2026 - Feb 25, 2026
#13	-9.02% Oct 1, 2013 - Nov 21, 2013	-2.09% Dec 11, 2025 - Dec 22, 2025
#14	-8.60% Sep 24, 2014 - Oct 23, 2014	-1.86% Jan 12, 2026 - Jan 27, 2026
#15	-7.55% Mar 20, 2015 - Apr 23, 2015	-1.80% May 1, 2023 - May 17, 2023

Correlation

Correlation between IBB and SPYI is 0.79 which considered as a strong positive correlation - the stocks tend to move together.

0.79

-101

Dividend Comparison (2007 - 2026)

IBB vs SPYI dividend yield comparison.

Year	IBB	SPYI
2026	0.07%	3.91%
2025	0.23%	11.70%
2024	0.29%	12.04%
2023	0.26%	12.01%
2022	0.31%	4.10%
2021	0.21%	0.00%
2020	0.21%	0.00%
2019	0.33%	0.00%
2018	0.20%	0.00%
2017	0.30%	0.00%
2016	0.19%	0.00%
2015	0.03%	0.00%
2014	0.15%	0.00%
2013	0.03%	0.00%
2012	0.48%	0.00%
2011	0.01%	0.00%
2010	0.55%	0.00%
2008	0.25%	0.00%
2007	0.11%	0.00%