GNOM vs XSPI
Comparison between GLOBAL X GENOMICS & BIOTECHNOLOGY ETF (GNOM, ETF) and NEOS Boosted S&P 500 High Income ETF (XSPI, ETF).
GNOM vs XSPI - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Net Assets
GNOM
$56M
Winner
XSPI
$56M
Expense Ratio
GNOM
0.50%
XSPI
N/A
Max Drawdown
GNOM
75.01%
Winner
XSPI
13.26%
Sharpe Ratio
Winner
GNOM
1.43
XSPI
0.78
5Y Beta
Winner
GNOM
1.14
XSPI
1.23
P/E Ratio
Winner
GNOM
-21.75
XSPI
27.77
Forward P/E
Winner
GNOM
20.24
XSPI
21.28
5Y Dividends CAGR
GNOM
36.95%
XSPI
N/A
5Y EPS CAGR
GNOM
-0.32%
Winner
XSPI
28.35%
Debt to Equity
Winner
GNOM
-24.24%
XSPI
42.47%
P/S Ratio
GNOM
6.10
Winner
XSPI
3.56
P/B Ratio
Winner
GNOM
3.71
XSPI
5.47
GNOM vs XSPI - Holdings Comparison
GNOM and XSPI have 10 common holdings. Overlap is 1.76%
GNOM's top 25 holdings weight is 82.28%. XSPI's top 25 holdings weight is 49.42%.
| Rank | GNOM | XSPI |
|---|---|---|
| #1 | GUARDANT HEALTH INC (GH) - 5.78% | NVIDIA CORP (NVDA) - 7.96% |
| #2 | LEGEND BIOTECH CORP ADR (LEGN) - 5.56% | APPLE INC (AAPL) - 6.69% |
| #3 | ILLUMINA INC (ILMN) - 4.95% | MICROSOFT CORP (MSFT) - 4.72% |
| #4 | TWIST BIOSCIENCE CORP (TWST) - 4.28% | AMAZON.COM INC (AMZN) - 3.74% |
| #5 | NATERA INC (NTRA) - 4.07% | ALPHABET INC CLASS A (GOOGL) - 3.35% |
| #6 | BIOMARIN PHARMACEUTICAL INC (BMRN) - 3.92% | BROADCOM INC (AVGO) - 2.93% |
| #7 | VERACYTE INC (VCYT) - 3.86% | ALPHABET INC CLASS C (GOOG) - 2.68% |
| #8 | VERTEX PHARMACEUTICALS INC (VRTX) - 3.86% | META PLATFORMS INC CLASS A (META) - 2.01% |
| #9 | ARROWHEAD PHARMACEUTICALS INC (ARWR) - 3.81% | TESLA INC (TSLA) - 1.75% |
| #10 | CRISPR THERAPEUTICS AG (CRSP) - 3.67% | MICRON TECHNOLOGY INC (MU) - 1.65% |
| #11 | 10X GENOMICS INC ORDINARY SHARES CLASS A (TXG) - 3.61% | ELI LILLY AND CO (LLY) - 1.42% |
| #12 | QIAGEN NV (QGEN) - 3.55% | BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.41% |
| #13 | BIO-TECHNE CORP (TECH) - 3.38% | JPMORGAN CHASE & CO (JPM) - 1.32% |
| #14 | BIONTECH SE ADR (BNTX) - 3.26% | ADVANCED MICRO DEVICES INC (AMD) - 1.21% |
| #15 | MODERNA INC (MRNA) - 3.26% | EXXON MOBIL CORP (XOM) - 0.98% |
| #16 | PRAXIS PRECISION MEDICINES INC ORDINARY SHARES (PRAX) - 3.04% | JOHNSON & JOHNSON (JNJ) - 0.90% |
| #17 | BEAM THERAPEUTICS INC (BEAM) - 2.80% | VISA INC CLASS A (V) - 0.86% |
| #18 | ELI LILLY AND CO (LLY) - 2.29% | WALMART INC (WMT) - 0.82% |
| #19 | ULTRAGENYX PHARMACEUTICAL INC (RARE) - 2.11% | INTEL CORP (INTC) - 0.79% |
| #20 | CARIS LIFE SCIENCES INC (CAI) - 2.07% | CISCO SYSTEMS INC (CSCO) - 0.75% |
| #21 | BILLIONTOONE INC ORDINARY SHARES CLASS A (BLLN) - 1.93% | ELEVANCE HEALTH INC (ELV) - 0.30% |
| #22 | GILEAD SCIENCES INC (GILD) - 1.91% | AUTOMATIC DATA PROCESSING INC (ADP) - 0.30% |
| #23 | GENSCRIPT BIOTECH CORP CLASS H (n/a) - 1.83% | ADOBE INC (ADBE) - 0.30% |
| #24 | ASTRAZENECA PLC (AZN) - 1.80% | SEAGATE TECHNOLOGY HOLDINGS PLC (STX) - 0.29% |
| #25 | SAREPTA THERAPEUTICS INC (SRPT) - 1.68% | AMGEN INC (AMGN) - 0.29% |
| Total Holdings | 51 | 469 |
GNOM vs XSPI - Historical Returns
Returns include dividend reinvestment.
1M
Winner
GNOM
+4.63%
XSPI
+0.24%
3M
Winner
GNOM
+12.25%
XSPI
+10.38%
6M
GNOM
+5.92%
XSPI
N/A
1Y
GNOM
+47.25%
XSPI
N/A
5Y(CAGR)
GNOM
-11.72%
XSPI
N/A
Max(CAGR)
GNOM
-2.92%
Winner
XSPI
+17.89%
GNOM vs XSPI - Annual Returns (2019 - 2026)
Returns include dividend reinvestment.
| Year | GNOM | XSPI |
|---|---|---|
| 2026 | +7.20% | +5.98% |
| 2025 | +17.51% | N/A |
| 2024 | -16.87% | N/A |
| 2023 | -7.68% | N/A |
| 2022 | -36.69% | N/A |
| 2021 | -16.36% | N/A |
| 2020 | +52.20% | N/A |
| 2019 | +1.56% | N/A |
GNOM vs XSPI Drawdown Comparison
The maximum drawdown for GNOM was -75.00%, occurring on Apr 8, 2025. This drawdown has not yet recovered.
The maximum drawdown for XSPI was -11.60%, occurring on Mar 30, 2026. Recovery took 47 trading sessions.
The current GNOM drawdown is -55.49%. The current XSPI drawdown is -2.88%.
| Rank | GNOM | XSPI |
|---|---|---|
| #1 | -75.00% Feb 8, 2021 - Apr 8, 2025 | -11.60% Feb 9, 2026 - Apr 17, 2026 |
| #2 | -35.36% Dec 24, 2019 - May 18, 2020 | -5.46% Jun 2, 2026 - Jun 10, 2026 |
| #3 | -21.60% Apr 10, 2019 - Nov 27, 2019 | -2.10% Feb 3, 2026 - Feb 6, 2026 |
| #4 | -14.38% Jul 20, 2020 - Oct 7, 2020 | -1.80% May 14, 2026 - May 26, 2026 |
| #5 | -9.15% Oct 13, 2020 - Nov 11, 2020 | -0.85% Apr 17, 2026 - Apr 24, 2026 |
| #6 | -9.00% Dec 23, 2020 - Jan 7, 2021 | -0.51% May 1, 2026 - May 5, 2026 |
| #7 | -8.39% Jan 20, 2021 - Feb 5, 2021 | -0.38% May 6, 2026 - May 8, 2026 |
| #8 | -7.39% Jun 2, 2020 - Jun 18, 2020 | -0.30% Apr 27, 2026 - Apr 30, 2026 |
| #9 | -4.90% Jun 23, 2020 - Jul 7, 2020 | -0.24% May 11, 2026 - May 13, 2026 |
| #10 | -4.42% Jul 9, 2020 - Jul 20, 2020 | -0.05% May 26, 2026 - May 28, 2026 |
| #11 | -3.33% Jan 7, 2021 - Jan 14, 2021 | N/A |
| #12 | -3.07% May 22, 2020 - Jun 2, 2020 | N/A |
| #13 | -2.25% Dec 6, 2019 - Dec 16, 2019 | N/A |
| #14 | -2.19% Nov 27, 2020 - Dec 1, 2020 | N/A |
| #15 | -1.85% Dec 16, 2019 - Dec 24, 2019 | N/A |
Correlation
Correlation between GNOM and XSPI is 0.85 which considered as a strong positive correlation - the stocks tend to move together.
0.85
-101
Dividend Comparison (2020 - 2026)
GNOM vs XSPI dividend yield comparison.
| Year | GNOM | XSPI |
|---|---|---|
| 2026 | 0.00% | 6.97% |
| 2025 | 1.37% | 0.00% |
| 2021 | 0.03% | 0.00% |
| 2020 | 0.14% | 0.00% |
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