FULC vs OSUR

Comparison between Fulcrum Therapeutics Inc (FULC, Company) and Orasure Technologies Inc (OSUR, Company).

Both FULC and OSUR are from the Healthcare sector.

5-Year PerformanceOSUR has outperformed FULC, delivering a return of -18.8% compared to -27.5%

FULC vs OSUR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	FULC(COMPANY)	OSUR(COMPANY)
Market Cap	$288M	$288M
Max Drawdown	92.70%	90.75%
Sharpe Ratio	-0.11	0.95
5Y Beta	1.11	1.08
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-2.91	-3.94
Forward P/E	N/A	40.00
PEG Ratio	N/A	-0.03
5Y EPS CAGR	-12.00%	81.11%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-23.00%	-16.62%
P/S Ratio	2.66	2.53
P/B Ratio	0.88	0.92

Market Cap

FULC

$288M

Winner

OSUR

$288M

Max Drawdown

FULC

92.70%

Winner

OSUR

90.75%

Sharpe Ratio

FULC

-0.11

Winner

OSUR

0.95

5Y Beta

FULC

1.11

Winner

OSUR

1.08

Industry

FULC

Biotechnology

OSUR

Medical Instruments & Supplies

P/E Ratio

FULC

-2.91

Winner

OSUR

-3.94

Forward P/E

FULC

N/A

OSUR

40.00

PEG Ratio

FULC

N/A

OSUR

-0.03

5Y EPS CAGR

FULC

-12.00%

Winner

OSUR

81.11%

Debt to Equity

FULC

0.00%

OSUR

0.00%

Free Cash Flow Yield

FULC

-23.00%

Winner

OSUR

-16.62%

P/S Ratio

FULC

2.66

Winner

OSUR

2.53

P/B Ratio

Winner

FULC

0.88

OSUR

0.92

FULC vs OSUR - Historical Returns

Returns include dividend reinvestment.

Period	FULC	OSUR
1 month	+7.14%	-6.87%
3 months	-46.43%	+32.45%
6 months	-63.73%	+42.35%
1 year	-40.85%	+43.37%
5 years(CAGR)	-27.54%	-18.79%
10 years(CAGR)	N/A	-5.51%
Max(CAGR)	-16.58%	-0.54%

Winner

FULC

+7.14%

OSUR

-6.87%

FULC

-46.43%

Winner

OSUR

+32.45%

FULC

-63.73%

Winner

OSUR

+42.35%

FULC

-40.85%

Winner

OSUR

+43.37%

5Y(CAGR)

FULC

-27.54%

Winner

OSUR

-18.79%

10Y(CAGR)

FULC

N/A

OSUR

-5.51%

Max(CAGR)

FULC

-16.58%

Winner

OSUR

-0.54%

FULC vs OSUR - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	FULC	OSUR
2026	-65.66%	+68.07%
2025	+133.68%	-31.64%
2024	-34.81%	-56.40%
2023	-14.56%	+71.19%
2022	-59.15%	-44.34%
2021	+42.43%	-22.48%
2020	-26.17%	+34.16%
2019	+23.26%	-31.19%
2018	N/A	-39.45%
2017	N/A	+114.56%
2016	N/A	+38.27%
2015	N/A	-35.28%
2014	N/A	+56.72%
2013	N/A	-13.24%
2012	N/A	-24.50%
2011	N/A	+51.58%
2010	N/A	+8.70%
2009	N/A	+38.80%
2008	N/A	-57.80%
2007	N/A	+9.08%
2006	N/A	-9.43%
2005	N/A	+33.64%
2004	N/A	-15.15%
2003	N/A	+41.13%
2002	N/A	-55.33%
2001	N/A	+61.33%
2000	N/A	+28.11%
1999	N/A	+40.39%

FULC vs OSUR Drawdown Comparison

The maximum drawdown for FULC was -92.70%, occurring on Apr 12, 2023. This drawdown has not yet recovered.

The maximum drawdown for OSUR was -90.75%, occurring on Nov 20, 2025. This drawdown has not yet recovered.

The current FULC drawdown is -87.89%. The current OSUR drawdown is -82.46%.

Rank	FULC	OSUR
#1	-92.70% Sep 20, 2021 - Apr 12, 2023	-90.75% Oct 2, 2017 - Nov 20, 2025
#2	-70.05% Jul 29, 2019 - Nov 25, 2019	-86.76% Mar 13, 2000 - Jun 27, 2017
#3	-67.27% Jun 25, 2020 - Aug 12, 2021	-20.73% Jan 21, 2000 - Feb 10, 2000
#4	-57.15% Jan 13, 2020 - Jun 25, 2020	-12.68% Dec 2, 1999 - Dec 21, 1999
#5	-26.98% Nov 25, 2019 - Dec 23, 2019	-12.00% Feb 10, 2000 - Feb 17, 2000
#6	-12.57% Dec 26, 2019 - Jan 8, 2020	-11.20% Nov 2, 1999 - Dec 1, 1999
#7	-11.72% Aug 31, 2021 - Sep 17, 2021	-10.71% Jan 10, 2000 - Jan 13, 2000
#8	-7.04% Jul 18, 2019 - Jul 26, 2019	-10.01% Jul 17, 2017 - Aug 3, 2017
#9	-5.19% Aug 13, 2021 - Aug 18, 2021	-9.19% Dec 30, 1999 - Jan 6, 2000
#10	-4.86% Aug 18, 2021 - Aug 20, 2021	-8.33% Feb 17, 2000 - Mar 1, 2000
#11	-3.00% Aug 20, 2021 - Aug 24, 2021	-6.94% Aug 8, 2017 - Sep 7, 2017
#12	-2.73% Aug 25, 2021 - Aug 30, 2021	-5.43% Jan 19, 2000 - Jan 21, 2000
#13	N/A	-5.04% Mar 6, 2000 - Mar 9, 2000
#14	N/A	-3.25% Jun 29, 2017 - Jul 5, 2017
#15	N/A	-3.07% Jul 5, 2017 - Jul 10, 2017