DRRX vs XLO

Comparison between Durect Corp (DRRX, Company) and Xilio Therapeutics Inc (XLO, Company).

Both DRRX and XLO are from the Healthcare sector.

5-Year PerformanceDRRX has outperformed XLO, delivering a return of -34.6% compared to -48.5%

DRRX vs XLO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	DRRX(COMPANY)	XLO(COMPANY)
Market Cap	$60M	$60M
Max Drawdown	99.68%	98.01%
Sharpe Ratio	0.66	-0.04
5Y Beta	N/A	0.78
Industry	Drug Manufacturers - Specialty & Generic	Biotechnology
P/E Ratio	-17.21	-1.91
5Y EPS CAGR	N/A	-46.63%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-23.46%	N/A
P/S Ratio	-49.64	1.13
P/B Ratio	17.09	0.83

Market Cap

DRRX

$60M

Winner

XLO

$60M

Max Drawdown

DRRX

99.68%

Winner

XLO

98.01%

Sharpe Ratio

Winner

DRRX

0.66

XLO

-0.04

5Y Beta

DRRX

N/A

XLO

0.78

Industry

DRRX

Drug Manufacturers - Specialty & Generic

XLO

Biotechnology

P/E Ratio

Winner

DRRX

-17.21

XLO

-1.91

5Y EPS CAGR

DRRX

N/A

XLO

-46.63%

Debt to Equity

DRRX

0.00%

XLO

0.00%

Free Cash Flow Yield

DRRX

-23.46%

XLO

N/A

P/S Ratio

Winner

DRRX

-49.64

XLO

1.13

P/B Ratio

DRRX

17.09

Winner

XLO

0.83

DRRX vs XLO - Historical Returns

Returns include dividend reinvestment.

Period	DRRX	XLO
1 month	+2.14%	+1.55%
3 months	+218.33%	+4.09%
6 months	+133.38%	+12.89%
1 year	+21.66%	-6.79%
5 years(CAGR)	-34.63%	-48.54%
10 years(CAGR)	-22.33%	N/A
Max(CAGR)	-15.91%	-48.54%

Winner

DRRX

+2.14%

XLO

+1.55%

Winner

DRRX

+218.33%

XLO

+4.09%

Winner

DRRX

+133.38%

XLO

+12.89%

Winner

DRRX

+21.66%

XLO

-6.79%

5Y(CAGR)

Winner

DRRX

-34.63%

XLO

-48.54%

10Y(CAGR)

DRRX

-22.33%

XLO

N/A

Max(CAGR)

Winner

DRRX

-15.91%

XLO

-48.54%

DRRX vs XLO - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	DRRX	XLO
2026	N/A	-2.49%
2025	+141.53%	-40.17%
2024	+35.14%	+66.09%
2023	-83.61%	-79.55%
2022	-64.51%	-83.24%
2021	-53.05%	+0.00%
2020	-20.99%	N/A
2019	+603.44%	N/A
2018	-47.49%	N/A
2017	-31.34%	N/A
2016	-34.31%	N/A
2015	+166.27%	N/A
2014	-54.38%	N/A
2013	+80.21%	N/A
2012	-23.33%	N/A
2011	-67.13%	N/A
2010	+34.77%	N/A
2009	-25.15%	N/A
2008	-45.41%	N/A
2007	+46.47%	N/A
2006	-12.43%	N/A
2005	+62.50%	N/A
2004	+24.24%	N/A
2003	+17.92%	N/A
2002	-81.72%	N/A
2001	+4.13%	N/A
2000	-16.72%	N/A

DRRX vs XLO Drawdown Comparison

The maximum drawdown for DRRX was -99.68%, occurring on May 27, 2025. This drawdown has not yet recovered.

The maximum drawdown for XLO was -98.01%, occurring on Dec 20, 2023. This drawdown has not yet recovered.

The current DRRX drawdown is -98.79%. The current XLO drawdown is -97.39%.

Rank	DRRX	XLO
#1	-99.68% Nov 6, 2000 - May 27, 2025	-98.01% Nov 16, 2021 - Dec 20, 2023
#2	-23.81% Oct 6, 2000 - Nov 6, 2000	-15.07% Nov 2, 2021 - Nov 4, 2021
#3	-8.73% Sep 29, 2000 - Oct 6, 2000	-7.66% Nov 4, 2021 - Nov 8, 2021
#4	N/A	-6.89% Nov 8, 2021 - Nov 16, 2021
#5	N/A	-2.19% Oct 26, 2021 - Oct 29, 2021