DNLI vs OSIS

Comparison between Denali Therapeutics Inc (DNLI, Company) and OSI Systems Inc (OSIS, Company).

DNLI is from the Healthcare sector, while OSIS is from the Technology sector.

5-Year PerformanceOSIS has outperformed DNLI, delivering a return of +17.8% compared to -14.0%

DNLI vs OSIS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	DNLI(COMPANY)	OSIS(COMPANY)
Market Cap	$4.04B	$3.82B
Max Drawdown	87.74%	88.44%
Sharpe Ratio	1.26	0.21
5Y Beta	1.47	1.20
Industry	Biotechnology	Electronic Components
P/E Ratio	-7.67	25.33
Forward P/E	N/A	20.28
PEG Ratio	N/A	2.87
5Y EPS CAGR	N/A	21.46%
Debt to Equity	0.00%	112.10%
Free Cash Flow Yield	-10.90%	1.75%

Market Cap

Winner

DNLI

$4.04B

OSIS

$3.82B

Max Drawdown

Winner

DNLI

87.74%

OSIS

88.44%

Sharpe Ratio

Winner

DNLI

1.26

OSIS

0.21

5Y Beta

DNLI

1.47

Winner

OSIS

1.20

Industry

DNLI

Biotechnology

OSIS

Electronic Components

P/E Ratio

Winner

DNLI

-7.67

OSIS

25.33

Forward P/E

DNLI

N/A

OSIS

20.28

PEG Ratio

DNLI

N/A

OSIS

2.87

5Y EPS CAGR

DNLI

N/A

OSIS

21.46%

Debt to Equity

Winner

DNLI

0.00%

OSIS

112.10%

Free Cash Flow Yield

DNLI

-10.90%

Winner

OSIS

1.75%

DNLI vs OSIS - Historical Returns

Returns include dividend reinvestment.

Period	DNLI	OSIS
1 month	-6.27%	+7.20%
3 months	+25.35%	+4.61%
6 months	+32.23%	-14.91%
1 year	+67.59%	-3.17%
5 years(CAGR)	-13.99%	+17.80%
10 years(CAGR)	+1.70%	+14.03%
Max(CAGR)	+1.70%	+17.21%

DNLI

-6.27%

Winner

OSIS

+7.20%

Winner

DNLI

+25.35%

OSIS

+4.61%

Winner

DNLI

+32.23%

OSIS

-14.91%

Winner

DNLI

+67.59%

OSIS

-3.17%

5Y(CAGR)

DNLI

-13.99%

Winner

OSIS

+17.80%

10Y(CAGR)

DNLI

+1.70%

Winner

OSIS

+14.03%

Max(CAGR)

DNLI

+1.70%

Winner

OSIS

+17.21%

DNLI vs OSIS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	DNLI	OSIS
2026	+52.55%	-10.57%
2025	-20.78%	+54.19%
2024	-4.72%	+29.84%
2023	-22.33%	+61.05%
2022	-41.17%	-15.14%
2021	-37.06%	+1.77%
2020	+411.04%	-8.76%
2019	-9.88%	+40.11%
2018	+28.08%	+12.56%
2017	-27.09%	-15.16%
2016	N/A	-11.78%
2015	N/A	+25.79%
2014	N/A	+35.57%
2013	N/A	-18.52%
2012	N/A	+29.48%
2011	N/A	+34.12%
2010	N/A	+30.51%
2009	N/A	+89.97%
2008	N/A	-45.94%
2007	N/A	+31.10%
2006	N/A	+12.10%
2005	N/A	-15.45%
2004	N/A	+17.55%
2003	N/A	+9.77%
2002	N/A	-2.41%
2001	N/A	+251.58%
2000	N/A	+13.95%
1999	N/A	+69.23%

DNLI vs OSIS Drawdown Comparison

The maximum drawdown for DNLI was -87.74%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for OSIS was -88.44%, occurring on Apr 6, 2001. Recovery took 468 trading sessions.

The current DNLI drawdown is -73.47%. The current OSIS drawdown is -26.19%.

Rank	DNLI	OSIS
#1	-87.74% Dec 22, 2020 - Apr 8, 2025	-88.44% Mar 17, 2000 - Jan 31, 2002
#2	-49.76% Feb 16, 2018 - Apr 2, 2019	-64.03% May 9, 2007 - Jan 8, 2010
#3	-49.54% Apr 10, 2019 - Jun 2, 2020	-53.64% Jul 5, 2019 - May 1, 2023
#4	-29.88% Dec 8, 2017 - Jan 22, 2018	-50.33% Mar 12, 2002 - Feb 26, 2007
#5	-19.74% Jun 3, 2020 - Aug 6, 2020	-48.65% Nov 23, 2015 - Oct 12, 2017
#6	-19.58% Jan 29, 2018 - Feb 16, 2018	-42.98% Oct 12, 2017 - May 1, 2019
#7	-13.33% Nov 12, 2020 - Dec 4, 2020	-41.43% Oct 25, 2012 - Oct 7, 2015
#8	-11.16% Aug 10, 2020 - Aug 25, 2020	-36.15% Apr 17, 2026 - Jun 5, 2026
#9	-10.43% Sep 17, 2020 - Oct 7, 2020	-32.00% Mar 9, 2000 - Mar 17, 2000
#10	-10.33% Oct 13, 2020 - Oct 27, 2020	-28.86% Jul 22, 2011 - Oct 27, 2011
#11	-9.64% Aug 25, 2020 - Sep 14, 2020	-25.97% Jan 11, 2010 - Sep 9, 2010
#12	-7.28% Oct 28, 2020 - Nov 4, 2020	-23.72% Aug 24, 2023 - Feb 9, 2024
#13	-3.20% Jan 23, 2018 - Jan 26, 2018	-20.66% Feb 19, 2025 - May 1, 2025
#14	-2.37% Apr 3, 2019 - Apr 5, 2019	-19.23% Jan 31, 2000 - Feb 22, 2000
#15	-1.33% Dec 16, 2020 - Dec 18, 2020	-18.73% Feb 4, 2002 - Mar 11, 2002