CMPX vs UPB

Comparison between Compass Therapeutics Inc (CMPX, Company) and Upstream Bio Inc (UPB, Company).

Both CMPX and UPB are from the Healthcare sector.

CMPX vs UPB - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	CMPX(COMPANY)	UPB(COMPANY)
Market Cap	$349M	$349M
Max Drawdown	90.91%	81.84%
Sharpe Ratio	0.08	-0.36
5Y Beta	1.57	1.09
Industry	Biotechnology	Biotechnology
P/E Ratio	-4.69	-2.21
PEG Ratio	-1.41	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-15.25%	-40.17%
P/S Ratio	269.28	105.01
P/B Ratio	1.97	1.15

Market Cap

Winner

CMPX

$349M

UPB

$349M

Max Drawdown

CMPX

90.91%

Winner

UPB

81.84%

Sharpe Ratio

Winner

CMPX

0.08

UPB

-0.36

5Y Beta

CMPX

1.57

Winner

UPB

1.09

Industry

CMPX

Biotechnology

UPB

Biotechnology

P/E Ratio

Winner

CMPX

-4.69

UPB

-2.21

PEG Ratio

CMPX

-1.41

UPB

N/A

Debt to Equity

CMPX

0.00%

UPB

0.00%

Free Cash Flow Yield

Winner

CMPX

-15.25%

UPB

-40.17%

P/S Ratio

CMPX

269.28

Winner

UPB

105.01

P/B Ratio

CMPX

1.97

Winner

UPB

1.15

CMPX vs UPB - Historical Returns

Returns include dividend reinvestment.

Period	CMPX	UPB
1 month	-11.42%	-5.06%
3 months	+9.60%	-28.43%
6 months	-69.69%	-78.86%
1 year	-36.39%	-56.75%
5 years(CAGR)	-16.92%	N/A
Max(CAGR)	-24.26%	-48.92%

CMPX

-11.42%

Winner

UPB

-5.06%

Winner

CMPX

+9.60%

UPB

-28.43%

Winner

CMPX

-69.69%

UPB

-78.86%

Winner

CMPX

-36.39%

UPB

-56.75%

5Y(CAGR)

CMPX

-16.92%

UPB

N/A

Max(CAGR)

Winner

CMPX

-24.26%

UPB

-48.92%

CMPX vs UPB - Annual Returns (2021 - 2026)

Returns include dividend reinvestment.

Year	CMPX	UPB
2026	-62.48%	-75.73%
2025	+283.57%	+66.56%
2024	-2.03%	-25.27%
2023	-69.71%	N/A
2022	+43.71%	N/A
2021	-62.71%	N/A

CMPX vs UPB Drawdown Comparison

The maximum drawdown for CMPX was -90.91%, occurring on Jul 5, 2024. This drawdown has not yet recovered.

The maximum drawdown for UPB was -81.84%, occurring on Jun 16, 2026. This drawdown has not yet recovered.

The current CMPX drawdown is -77.95%. The current UPB drawdown is -79.85%.

Rank	CMPX	UPB
#1	-90.91% Apr 16, 2021 - Jul 5, 2024	-81.84% Jan 13, 2026 - Jun 16, 2026
#2	N/A	-77.84% Nov 5, 2024 - Nov 25, 2025
#3	N/A	-14.99% Dec 22, 2025 - Jan 12, 2026
#4	N/A	-13.70% Dec 1, 2025 - Dec 16, 2025
#5	N/A	-6.45% Oct 21, 2024 - Nov 5, 2024
#6	N/A	-3.38% Dec 16, 2025 - Dec 18, 2025
#7	N/A	-2.88% Nov 25, 2025 - Dec 1, 2025
#8	N/A	-1.71% Dec 18, 2025 - Dec 22, 2025
#9	N/A	-1.63% Oct 14, 2024 - Oct 16, 2024
#10	N/A	-0.13% Oct 16, 2024 - Oct 18, 2024