CELC vs SYRE

Comparison between Celcuity Inc (CELC, Company) and Spyre Therapeutics Inc (SYRE, Company).

Both CELC and SYRE are from the Healthcare sector.

5-Year PerformanceCELC has outperformed SYRE, delivering a return of +37.1% compared to -17.6%

CELC vs SYRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	CELC(COMPANY)	SYRE(COMPANY)
Market Cap	$6.01B	$6.02B
Max Drawdown	85.64%	99.11%
Sharpe Ratio	1.90	2.61
5Y Beta	1.07	1.73
Industry	Biotechnology	Biotechnology
P/E Ratio	-29.57	-30.92
PEG Ratio	-0.86	N/A
5Y EPS CAGR	37.13%	-2.15%
Debt to Equity	136.79%	0.00%
Free Cash Flow Yield	-2.56%	-3.09%
P/S Ratio	N/A	650.22
P/B Ratio	63.02	12.65

Market Cap

CELC

$6.01B

Winner

SYRE

$6.02B

Max Drawdown

Winner

CELC

85.64%

SYRE

99.11%

Sharpe Ratio

CELC

1.90

Winner

SYRE

2.61

5Y Beta

Winner

CELC

1.07

SYRE

1.73

Industry

CELC

Biotechnology

SYRE

Biotechnology

P/E Ratio

CELC

-29.57

Winner

SYRE

-30.92

PEG Ratio

CELC

-0.86

SYRE

N/A

5Y EPS CAGR

Winner

CELC

37.13%

SYRE

-2.15%

Debt to Equity

CELC

136.79%

Winner

SYRE

0.00%

Free Cash Flow Yield

Winner

CELC

-2.56%

SYRE

-3.09%

P/S Ratio

CELC

N/A

SYRE

650.22

P/B Ratio

CELC

63.02

Winner

SYRE

12.65

CELC vs SYRE - Historical Returns

Returns include dividend reinvestment.

Period	CELC	SYRE
1 month	+7.94%	-4.01%
3 months	+25.04%	+91.48%
6 months	+44.30%	+190.79%
1 year	+1136.48%	+370.97%
5 years(CAGR)	+37.14%	-17.65%
10 years(CAGR)	+29.30%	-9.26%
Max(CAGR)	+29.30%	-11.62%

Winner

CELC

+7.94%

SYRE

-4.01%

CELC

+25.04%

Winner

SYRE

+91.48%

CELC

+44.30%

Winner

SYRE

+190.79%

Winner

CELC

+1136.48%

SYRE

+370.97%

5Y(CAGR)

Winner

CELC

+37.14%

SYRE

-17.65%

10Y(CAGR)

Winner

CELC

+29.30%

SYRE

-9.26%

Max(CAGR)

Winner

CELC

+29.30%

SYRE

-11.62%

CELC vs SYRE - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	CELC	SYRE
2026	+31.46%	+129.17%
2025	+659.63%	+37.36%
2024	-11.43%	+8.79%
2023	+13.65%	+104.27%
2022	+5.10%	-90.57%
2021	+26.46%	-44.51%
2020	-21.58%	+1.55%
2019	-53.46%	-4.98%
2018	+16.91%	+39.22%
2017	+32.61%	+18.38%
2016	N/A	-55.48%

CELC vs SYRE Drawdown Comparison

The maximum drawdown for CELC was -85.64%, occurring on Apr 16, 2020. Recovery took 696 trading sessions.

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The current CELC drawdown is -8.83%. The current SYRE drawdown is -76.62%.

Rank	CELC	SYRE
#1	-85.64% Sep 20, 2018 - Jun 28, 2021	-99.11% Apr 8, 2016 - Jun 21, 2023
#2	-82.70% Jun 28, 2021 - Jul 28, 2025	N/A
#3	-37.41% Nov 10, 2017 - Jun 22, 2018	N/A
#4	-27.68% Sep 8, 2025 - Oct 20, 2025	N/A
#5	-22.34% Jun 27, 2018 - Sep 14, 2018	N/A
#6	-16.45% Sep 20, 2017 - Oct 13, 2017	N/A
#7	-14.15% May 4, 2026 - May 13, 2026	N/A
#8	-13.00% Jan 27, 2026 - Apr 9, 2026	N/A
#9	-9.92% Apr 21, 2026 - May 4, 2026	N/A
#10	-8.04% Jan 14, 2026 - Jan 27, 2026	N/A
#11	-7.56% Oct 30, 2025 - Nov 11, 2025	N/A
#12	-7.20% Oct 20, 2025 - Oct 24, 2025	N/A
#13	-6.87% Aug 13, 2025 - Aug 22, 2025	N/A
#14	-6.44% Dec 4, 2025 - Jan 7, 2026	N/A
#15	-6.17% Aug 28, 2025 - Sep 5, 2025	N/A