BMEA vs LPTX

Comparison between Biomea Fusion Inc (BMEA, Company) and Leap Therapeutics Inc (LPTX, Company).

Both BMEA and LPTX are from the Healthcare sector.

5-Year PerformanceLPTX has outperformed BMEA, delivering a return of -33.2% compared to -39.6%

BMEA vs LPTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	BMEA(COMPANY)	LPTX(COMPANY)
Market Cap	$85M	$85M
Max Drawdown	97.71%	99.76%
Sharpe Ratio	-0.01	0.73
5Y Beta	N/A	1.36
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.59	-1.29
Debt to Equity	0.00%	0.68%
Free Cash Flow Yield	-66.08%	-70.88%
P/S Ratio	N/A	8475.88
P/B Ratio	4.56	14.83

Market Cap

Winner

BMEA

$85M

LPTX

$85M

Max Drawdown

Winner

BMEA

97.71%

LPTX

99.76%

Sharpe Ratio

BMEA

-0.01

Winner

LPTX

0.73

5Y Beta

BMEA

N/A

LPTX

1.36

Industry

BMEA

Biotechnology

LPTX

Biotechnology

P/E Ratio

Winner

BMEA

-1.59

LPTX

-1.29

Debt to Equity

Winner

BMEA

0.00%

LPTX

0.68%

Free Cash Flow Yield

Winner

BMEA

-66.08%

LPTX

-70.88%

P/S Ratio

BMEA

N/A

LPTX

8475.88

P/B Ratio

Winner

BMEA

4.56

LPTX

14.83

BMEA vs LPTX - Historical Returns

Returns include dividend reinvestment.

Period	BMEA	LPTX
1 month	-11.97%	+239.91%
3 months	+10.62%	+533.89%
6 months	-3.10%	+446.52%
1 year	-33.51%	-36.92%
5 years(CAGR)	-39.62%	-33.19%
10 years(CAGR)	N/A	-33.94%
Max(CAGR)	-40.57%	-33.94%

BMEA

-11.97%

Winner

LPTX

+239.91%

BMEA

+10.62%

Winner

LPTX

+533.89%

BMEA

-3.10%

Winner

LPTX

+446.52%

Winner

BMEA

-33.51%

LPTX

-36.92%

5Y(CAGR)

BMEA

-39.62%

Winner

LPTX

-33.19%

10Y(CAGR)

BMEA

N/A

LPTX

-33.94%

Max(CAGR)

BMEA

-40.57%

Winner

LPTX

-33.94%

BMEA vs LPTX - Annual Returns (2017 - 2026)

Returns include dividend reinvestment.

Year	BMEA	LPTX
2026	-6.72%	N/A
2025	-66.40%	-36.34%
2024	-73.55%	-38.44%
2023	+71.23%	-3.60%
2022	-0.59%	-86.57%
2021	-59.95%	+48.62%
2020	N/A	+112.26%
2019	N/A	-54.10%
2018	N/A	-67.79%
2017	N/A	-20.61%

BMEA vs LPTX Drawdown Comparison

The maximum drawdown for BMEA was -97.71%, occurring on Dec 2, 2025. This drawdown has not yet recovered.

The maximum drawdown for LPTX was -99.76%, occurring on Aug 14, 2025. This drawdown has not yet recovered.

The current BMEA drawdown is -97.01%. The current LPTX drawdown is -97.95%.

Rank	BMEA	LPTX
#1	-97.71% Jun 8, 2023 - Dec 2, 2025	-99.76% Apr 12, 2018 - Aug 14, 2025
#2	-85.67% Jun 10, 2021 - Mar 28, 2023	-46.34% Mar 8, 2017 - Apr 5, 2018
#3	-25.87% Mar 29, 2023 - May 5, 2023	-28.81% Jan 26, 2017 - Mar 7, 2017
#4	-14.68% Apr 16, 2021 - Jun 1, 2021	-9.00% Apr 5, 2018 - Apr 12, 2018
#5	-8.65% May 12, 2023 - Jun 1, 2023	N/A
#6	-4.86% May 9, 2023 - May 12, 2023	N/A
#7	-3.42% Jun 2, 2021 - Jun 7, 2021	N/A