BCYC vs CARL

Comparison between Bicycle Therapeutics Plc (BCYC, Company) and Carlsmed Inc (CARL, Company).

Both BCYC and CARL are from the Healthcare sector.

BCYC vs CARL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	BCYC(COMPANY)	CARL(COMPANY)
Market Cap	$319M	$319M
Max Drawdown	92.97%	48.03%
Sharpe Ratio	-1.03	-0.26
5Y Beta	1.29	1.60
Industry	Biotechnology	Health Information Services
P/E Ratio	-1.45	-10.52
PEG Ratio	-0.20	N/A
5Y EPS CAGR	11.06%	N/A
Debt to Equity	0.00%	16.66%
Free Cash Flow Yield	-72.73%	-14.11%
P/S Ratio	5.16	5.50
P/B Ratio	0.59	3.37

Market Cap

BCYC

$319M

Winner

CARL

$319M

Max Drawdown

BCYC

92.97%

Winner

CARL

48.03%

Sharpe Ratio

BCYC

-1.03

Winner

CARL

-0.26

5Y Beta

Winner

BCYC

1.29

CARL

1.60

Industry

BCYC

Biotechnology

CARL

Health Information Services

P/E Ratio

BCYC

-1.45

Winner

CARL

-10.52

PEG Ratio

BCYC

-0.20

CARL

N/A

5Y EPS CAGR

BCYC

11.06%

CARL

N/A

Debt to Equity

Winner

BCYC

0.00%

CARL

16.66%

Free Cash Flow Yield

BCYC

-72.73%

Winner

CARL

-14.11%

P/S Ratio

Winner

BCYC

5.16

CARL

5.50

P/B Ratio

Winner

BCYC

0.59

CARL

3.37

BCYC vs CARL - Historical Returns

Returns include dividend reinvestment.

Period	BCYC	CARL
1 month	-10.42%	+7.28%
3 months	-24.96%	-23.93%
6 months	-37.41%	-32.69%
1 year	-49.71%	-29.86%
5 years(CAGR)	-31.74%	N/A
Max(CAGR)	-13.59%	-33.81%

BCYC

-10.42%

Winner

CARL

+7.28%

BCYC

-24.96%

Winner

CARL

-23.93%

BCYC

-37.41%

Winner

CARL

-32.69%

BCYC

-49.71%

Winner

CARL

-29.86%

5Y(CAGR)

BCYC

-31.74%

CARL

N/A

Max(CAGR)

Winner

BCYC

-13.59%

CARL

-33.81%

BCYC vs CARL - Annual Returns (2019 - 2026)

Returns include dividend reinvestment.

Year	BCYC	CARL
2026	-35.63%	-12.55%
2025	-50.70%	-14.83%
2024	-24.08%	N/A
2023	-39.73%	N/A
2022	-50.25%	N/A
2021	+217.03%	N/A
2020	+82.79%	N/A
2019	-21.42%	N/A

BCYC vs CARL Drawdown Comparison

The maximum drawdown for BCYC was -92.97%, occurring on Jun 2, 2026. This drawdown has not yet recovered.

The maximum drawdown for CARL was -48.03%, occurring on Apr 29, 2026. This drawdown has not yet recovered.

The current BCYC drawdown is -92.97%. The current CARL drawdown is -40.14%.

Rank	BCYC	CARL
#1	-92.97% Nov 15, 2021 - Jun 2, 2026	-48.03% Dec 3, 2025 - Apr 29, 2026
#2	-53.96% Jun 19, 2019 - Feb 14, 2020	-23.00% Sep 18, 2025 - Nov 26, 2025
#3	-41.61% Mar 10, 2020 - May 28, 2020	-17.39% Jul 30, 2025 - Sep 12, 2025
#4	-25.95% Feb 5, 2021 - Apr 1, 2021	-7.92% Nov 28, 2025 - Dec 3, 2025
#5	-20.84% Jul 23, 2021 - Aug 30, 2021	-1.57% Sep 16, 2025 - Sep 18, 2025
#6	-18.83% Feb 26, 2020 - Mar 4, 2020	-0.95% Sep 12, 2025 - Sep 16, 2025
#7	-18.70% Jul 15, 2020 - Sep 16, 2020	-0.34% Jul 23, 2025 - Jul 30, 2025
#8	-16.36% Apr 8, 2021 - Jul 13, 2021	N/A
#9	-15.98% Jun 8, 2020 - Jul 14, 2020	N/A
#10	-15.96% Nov 30, 2020 - Jan 14, 2021	N/A
#11	-15.70% Mar 4, 2020 - Mar 10, 2020	N/A
#12	-14.32% Jan 19, 2021 - Feb 5, 2021	N/A
#13	-14.18% May 24, 2019 - Jun 14, 2019	N/A
#14	-13.83% Oct 14, 2021 - Nov 15, 2021	N/A
#15	-12.02% Sep 21, 2020 - Nov 17, 2020	N/A