AVTX vs PBYI

Comparison between Avalo Therapeutics Inc (AVTX, Company) and Puma Biotechnology Inc (PBYI, Company).

Both AVTX and PBYI are from the Healthcare sector.

5-Year PerformancePBYI has outperformed AVTX, delivering a return of -4.3% compared to -71.8%

AVTX vs PBYI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	AVTX(COMPANY)	PBYI(COMPANY)
Market Cap	$404M	$404M
Max Drawdown	99.98%	99.40%
Sharpe Ratio	1.85	1.54
5Y Beta	0.54	0.79
Industry	Biotechnology	Biotechnology
P/E Ratio	-3.90	16.37
Forward P/E	N/A	3.46
Debt to Equity	0.00%	8.79%
Free Cash Flow Yield	-12.74%	13.23%
P/S Ratio	9875.25	N/A
P/B Ratio	3.78	N/A

Market Cap

AVTX

$404M

Winner

PBYI

$404M

Max Drawdown

AVTX

99.98%

Winner

PBYI

99.40%

Sharpe Ratio

Winner

AVTX

1.85

PBYI

1.54

5Y Beta

Winner

AVTX

0.54

PBYI

0.79

Industry

AVTX

Biotechnology

PBYI

Biotechnology

P/E Ratio

Winner

AVTX

-3.90

PBYI

16.37

Forward P/E

AVTX

N/A

PBYI

3.46

Debt to Equity

Winner

AVTX

0.00%

PBYI

8.79%

Free Cash Flow Yield

AVTX

-12.74%

Winner

PBYI

13.23%

P/S Ratio

AVTX

9875.25

PBYI

N/A

P/B Ratio

AVTX

3.78

PBYI

N/A

AVTX vs PBYI - Historical Returns

Returns include dividend reinvestment.

Period	AVTX	PBYI
1 month	+11.07%	+12.29%
3 months	+35.02%	+27.00%
6 months	-3.97%	+33.39%
1 year	+266.87%	+136.61%
5 years(CAGR)	-71.81%	-4.29%
10 years(CAGR)	-44.80%	-12.62%
Max(CAGR)	-45.56%	-3.92%

AVTX

+11.07%

Winner

PBYI

+12.29%

Winner

AVTX

+35.02%

PBYI

+27.00%

AVTX

-3.97%

Winner

PBYI

+33.39%

Winner

AVTX

+266.87%

PBYI

+136.61%

5Y(CAGR)

AVTX

-71.81%

Winner

PBYI

-4.29%

10Y(CAGR)

AVTX

-44.80%

Winner

PBYI

-12.62%

Max(CAGR)

AVTX

-45.56%

Winner

PBYI

-3.92%

AVTX vs PBYI - Annual Returns (2012 - 2026)

Returns include dividend reinvestment.

Year	AVTX	PBYI
2026	+6.70%	+37.78%
2025	+115.42%	+90.71%
2024	-14.70%	-32.60%
2023	-99.24%	+4.84%
2022	-76.80%	+32.60%
2021	-35.61%	-70.57%
2020	-47.51%	+21.71%
2019	+54.44%	-59.64%
2018	-3.00%	-78.04%
2017	+259.51%	+213.81%
2016	-77.13%	-58.25%
2015	-16.25%	-58.71%
2014	N/A	+85.45%
2013	N/A	+444.61%
2012	N/A	+33.93%

AVTX vs PBYI Drawdown Comparison

The maximum drawdown for AVTX was -99.98%, occurring on May 28, 2025. This drawdown has not yet recovered.

The maximum drawdown for PBYI was -99.40%, occurring on May 11, 2022. This drawdown has not yet recovered.

The current AVTX drawdown is -99.91%. The current PBYI drawdown is -97.11%.

Rank	AVTX	PBYI
#1	-99.98% Feb 27, 2019 - May 28, 2025	-99.40% Sep 18, 2014 - May 11, 2022
#2	-91.55% Nov 23, 2016 - Mar 7, 2018	-60.70% Jan 21, 2014 - Jul 23, 2014
#3	-60.57% Mar 17, 2016 - Nov 18, 2016	-39.73% Sep 9, 2013 - Dec 5, 2013
#4	-46.64% Mar 7, 2018 - Feb 25, 2019	-23.10% Jul 23, 2014 - Aug 18, 2014
#5	-35.56% Nov 16, 2015 - Mar 16, 2016	-21.43% Apr 24, 2012 - Aug 20, 2012
#6	N/A	-19.73% Oct 23, 2012 - Jan 15, 2013
#7	N/A	-19.28% Apr 17, 2013 - May 16, 2013
#8	N/A	-18.00% Jul 22, 2013 - Sep 9, 2013
#9	N/A	-15.23% Jan 24, 2013 - Mar 6, 2013
#10	N/A	-14.09% May 29, 2013 - Jun 19, 2013
#11	N/A	-10.14% Oct 8, 2012 - Oct 19, 2012
#12	N/A	-9.33% Aug 18, 2014 - Aug 26, 2014
#13	N/A	-8.78% Dec 9, 2013 - Dec 16, 2013
#14	N/A	-8.36% Mar 28, 2013 - Apr 15, 2013
#15	N/A	-7.30% Dec 24, 2013 - Jan 9, 2014