AMLX vs PVLA
Comparison between Amylyx Pharmaceuticals Inc (AMLX, Company) and Palvella Therapeutics Inc (PVLA, Company).
Both AMLX and PVLA are from the Healthcare sector.
AMLX vs PVLA - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap
Winner
AMLX
$1.99B
PVLA
$1.98B
Max Drawdown
AMLX
96.04%
Winner
PVLA
31.48%
Sharpe Ratio
AMLX
1.95
Winner
PVLA
2.63
5Y Beta
AMLX
1.19
Winner
PVLA
1.02
Industry
AMLX
Drug Manufacturers - Specialty & Generic
PVLA
Biotechnology
P/E Ratio
AMLX
-12.38
Winner
PVLA
-34.50
Forward P/E
AMLX
2.77
PVLA
N/A
Debt to Equity
AMLX
0.00%
PVLA
0.00%
Free Cash Flow Yield
AMLX
-6.05%
Winner
PVLA
-1.47%
P/S Ratio
AMLX
0.66
PVLA
N/A
P/B Ratio
Winner
AMLX
7.30
PVLA
8.53
AMLX vs PVLA - Historical Returns
Returns include dividend reinvestment.
1M
AMLX
+37.47%
Winner
PVLA
+40.21%
3M
Winner
AMLX
+22.21%
PVLA
+18.87%
6M
Winner
AMLX
+59.98%
PVLA
+46.35%
1Y
AMLX
+178.08%
Winner
PVLA
+515.99%
5Y(CAGR)
AMLX
+0.25%
PVLA
N/A
Max(CAGR)
AMLX
+0.25%
Winner
PVLA
+385.99%
AMLX vs PVLA - Annual Returns (2022 - 2026)
Returns include dividend reinvestment.
| Year | AMLX | PVLA |
|---|---|---|
| 2026 | +59.98% | +46.35% |
| 2025 | +208.95% | +772.25% |
| 2024 | -74.75% | -6.47% |
| 2023 | -59.09% | N/A |
| 2022 | +104.48% | N/A |
AMLX vs PVLA Drawdown Comparison
The maximum drawdown for AMLX was -96.04%, occurring on Jun 18, 2024. This drawdown has not yet recovered.
The maximum drawdown for PVLA was -31.48%, occurring on Apr 10, 2025. Recovery took 87 trading sessions.
The current AMLX drawdown is -55.36%. The current PVLA drawdown is -5.22%.
| Rank | AMLX | PVLA |
|---|---|---|
| #1 | -96.04% Jan 27, 2023 - Jun 18, 2024 | -31.48% Mar 12, 2025 - Jul 17, 2025 |
| #2 | -79.18% Feb 28, 2022 - Oct 10, 2022 | -31.11% Feb 26, 2026 - Jun 29, 2026 |
| #3 | -17.59% Feb 1, 2022 - Feb 18, 2022 | -29.93% Dec 22, 2025 - Feb 24, 2026 |
| #4 | -15.23% Dec 1, 2022 - Jan 24, 2023 | -15.35% Jan 6, 2025 - Feb 5, 2025 |
| #5 | -13.39% Oct 26, 2022 - Nov 25, 2022 | -13.44% Nov 28, 2025 - Dec 22, 2025 |
| #6 | -12.97% Jan 19, 2022 - Jan 31, 2022 | -10.71% Jun 29, 2026 - Jul 1, 2026 |
| #7 | -7.90% Jan 13, 2022 - Jan 19, 2022 | -10.43% Feb 18, 2025 - Mar 5, 2025 |
| #8 | -7.47% Jan 7, 2022 - Jan 11, 2022 | -9.32% Oct 20, 2025 - Oct 30, 2025 |
| #9 | -5.42% Nov 25, 2022 - Dec 1, 2022 | -9.31% Dec 17, 2024 - Jan 3, 2025 |
| #10 | -3.44% Feb 22, 2022 - Feb 24, 2022 | -9.12% Aug 27, 2025 - Sep 9, 2025 |
| #11 | -3.19% Oct 10, 2022 - Oct 13, 2022 | -8.74% Sep 10, 2025 - Sep 29, 2025 |
| #12 | -2.79% Oct 13, 2022 - Oct 17, 2022 | -8.33% Jul 28, 2025 - Aug 8, 2025 |
| #13 | -1.41% Oct 18, 2022 - Oct 21, 2022 | -6.61% Oct 8, 2025 - Oct 13, 2025 |
| #14 | -1.06% Jan 25, 2023 - Jan 27, 2023 | -6.16% Aug 22, 2025 - Aug 26, 2025 |
| #15 | N/A | -5.99% Oct 31, 2025 - Nov 10, 2025 |
Correlation
Correlation between AMLX and PVLA is 0.94 which considered as a very strong positive correlation - the stocks move almost identically together.
0.94
-101
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