ACTU vs VYNE

Comparison between Actuate Therapeutics Inc (ACTU, Company) and VYNE Therapeutics Inc (VYNE, Company).

Both ACTU and VYNE are from the Healthcare sector.

ACTU vs VYNE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ACTU(COMPANY)	VYNE(COMPANY)
Market Cap	$30M	$30M
Max Drawdown	90.34%	N/A
Sharpe Ratio	-1.38	0.28
5Y Beta	1.01	1.14
Industry	Biotechnology	Biotechnology
P/E Ratio	-1.32	-0.51
5Y EPS CAGR	N/A	-49.07%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-65.36%	N/A
P/S Ratio	N/A	66.01
P/B Ratio	8.54	1.20

Market Cap

Winner

ACTU

$30M

VYNE

$30M

Max Drawdown

ACTU

90.34%

VYNE

N/A

Sharpe Ratio

ACTU

-1.38

Winner

VYNE

0.28

5Y Beta

Winner

ACTU

1.01

VYNE

1.14

Industry

ACTU

Biotechnology

VYNE

Biotechnology

P/E Ratio

Winner

ACTU

-1.32

VYNE

-0.51

5Y EPS CAGR

ACTU

N/A

VYNE

-49.07%

Debt to Equity

ACTU

0.00%

VYNE

0.00%

Free Cash Flow Yield

ACTU

-65.36%

VYNE

N/A

P/S Ratio

ACTU

N/A

VYNE

66.01

P/B Ratio

ACTU

8.54

Winner

VYNE

1.20

ACTU vs VYNE - Historical Returns

Returns include dividend reinvestment.

Period	ACTU	VYNE
1 month	-31.55%	N/A
3 months	-59.65%	N/A
6 months	-78.90%	N/A
1 year	-83.24%	N/A
Max(CAGR)	-64.35%	N/A

ACTU

-31.55%

VYNE

N/A

ACTU

-59.65%

VYNE

N/A

ACTU

-78.90%

VYNE

N/A

ACTU

-83.24%

VYNE

N/A

Max(CAGR)

ACTU

-64.35%

VYNE

N/A

ACTU vs VYNE - Annual Returns (2024 - 2026)

Returns include dividend reinvestment.

Year	ACTU	VYNE
2026	-80.93%	+0.00%
2025	-23.12%	N/A
2024	-7.55%	N/A

ACTU vs VYNE Drawdown Comparison

The maximum drawdown for ACTU was -90.34%, occurring on Jul 27, 2026. This drawdown has not yet recovered.

The current ACTU drawdown is -90.34%.

Rank	ACTU	VYNE
#1	-90.34% May 30, 2025 - Jul 27, 2026	N/A
#2	-40.82% Jan 23, 2025 - May 30, 2025	N/A
#3	-36.61% Aug 14, 2024 - Oct 28, 2024	N/A
#4	-26.65% Oct 28, 2024 - Jan 21, 2025	N/A