ACIU vs OBIO

Comparison between AC Immune SA (ACIU, Company) and Orchestra BioMed Holdings Inc (OBIO, Company).

Both ACIU and OBIO are from the Healthcare sector.

5-Year PerformanceOBIO has outperformed ACIU, delivering a return of -16.6% compared to -20.1%

ACIU vs OBIO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ACIU(COMPANY)	OBIO(COMPANY)
Market Cap	$224M	$223M
Max Drawdown	92.33%	89.40%
Sharpe Ratio	0.34	0.63
5Y Beta	1.05	1.65
Industry	Biotechnology	Biotechnology
P/E Ratio	-2.72	-3.41
Forward P/E	11.24	N/A
PEG Ratio	-0.06	N/A
5Y EPS CAGR	-4.76%	N/A
Debt to Equity	13.65%	36.41%
Free Cash Flow Yield	-28.64%	-24.72%
P/S Ratio	62.41	6.95
P/B Ratio	6.10	5.60

Market Cap

Winner

ACIU

$224M

OBIO

$223M

Max Drawdown

ACIU

92.33%

Winner

OBIO

89.40%

Sharpe Ratio

ACIU

0.34

Winner

OBIO

0.63

5Y Beta

Winner

ACIU

1.05

OBIO

1.65

Industry

ACIU

Biotechnology

OBIO

Biotechnology

P/E Ratio

ACIU

-2.72

Winner

OBIO

-3.41

Forward P/E

ACIU

11.24

OBIO

N/A

PEG Ratio

ACIU

-0.06

OBIO

N/A

5Y EPS CAGR

ACIU

-4.76%

OBIO

N/A

Debt to Equity

Winner

ACIU

13.65%

OBIO

36.41%

Free Cash Flow Yield

ACIU

-28.64%

Winner

OBIO

-24.72%

P/S Ratio

ACIU

62.41

Winner

OBIO

6.95

P/B Ratio

ACIU

6.10

Winner

OBIO

5.60

ACIU vs OBIO - Historical Returns

Returns include dividend reinvestment.

Period	ACIU	OBIO
1 month	-0.42%	-7.53%
3 months	-21.78%	+0.00%
6 months	-25.71%	+14.33%
1 year	+8.72%	+27.88%
5 years(CAGR)	-20.11%	-16.64%
10 years(CAGR)	-17.45%	N/A
Max(CAGR)	-17.45%	-16.09%

Winner

ACIU

-0.42%

OBIO

-7.53%

ACIU

-21.78%

Winner

OBIO

+0.00%

ACIU

-25.71%

Winner

OBIO

+14.33%

ACIU

+8.72%

Winner

OBIO

+27.88%

5Y(CAGR)

ACIU

-20.11%

Winner

OBIO

-16.64%

10Y(CAGR)

ACIU

-17.45%

OBIO

N/A

Max(CAGR)

ACIU

-17.45%

Winner

OBIO

-16.09%

ACIU vs OBIO - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	ACIU	OBIO
2026	-29.46%	-7.42%
2025	+10.18%	-22.86%
2024	-42.43%	-54.44%
2023	+126.24%	-9.06%
2022	-60.47%	+0.71%
2021	-6.95%	-22.46%
2020	-40.30%	+12.37%
2019	-16.63%	N/A
2018	-29.21%	N/A
2017	-1.61%	N/A
2016	-17.11%	N/A

ACIU vs OBIO Drawdown Comparison

The maximum drawdown for ACIU was -92.33%, occurring on Apr 10, 2025. This drawdown has not yet recovered.

The maximum drawdown for OBIO was -89.40%, occurring on Sep 23, 2025. This drawdown has not yet recovered.

The current ACIU drawdown is -87.72%. The current OBIO drawdown is -82.01%.

Rank	ACIU	OBIO
#1	-92.33% Sep 28, 2016 - Apr 10, 2025	-89.40% Apr 12, 2023 - Sep 23, 2025
#2	N/A	-42.60% Feb 16, 2021 - Mar 6, 2023
#3	N/A	-33.00% Mar 6, 2023 - Mar 31, 2023
#4	N/A	-14.37% Aug 6, 2020 - Dec 30, 2020
#5	N/A	-13.31% Dec 30, 2020 - Feb 8, 2021
#6	N/A	-5.52% Mar 31, 2023 - Apr 5, 2023
#7	N/A	-1.63% Apr 5, 2023 - Apr 11, 2023
#8	N/A	-0.53% Feb 8, 2021 - Feb 10, 2021